Incidental Mutation 'R4828:Dlc1'
| ID |
372587 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlc1
|
| Ensembl Gene |
ENSMUSG00000031523 |
| Gene Name |
deleted in liver cancer 1 |
| Synonyms |
p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12 |
| MMRRC Submission |
042444-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4828 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
37034905-37420297 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 37317400 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 425
(Q425L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132812
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163663]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000036104
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163663
AA Change: Q425L
PolyPhen 2
Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000132812
Gene: ENSMUSG00000031523
AA Change: Q425L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
353 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
403 |
N/A |
INTRINSIC |
|
Pfam:SAM_2
|
466 |
527 |
1.2e-7 |
PFAM |
|
low complexity region
|
605 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
689 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
892 |
N/A |
INTRINSIC |
|
RhoGAP
|
1104 |
1296 |
8.82e-59 |
SMART |
|
START
|
1338 |
1539 |
3.93e-59 |
SMART |
|
| Meta Mutation Damage Score |
0.0781 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
98% (106/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
A |
T |
7: 119,815,470 (GRCm39) |
R239S |
probably damaging |
Het |
| Adat3 |
T |
C |
10: 80,442,881 (GRCm39) |
S240P |
probably benign |
Het |
| Agbl5 |
G |
A |
5: 31,048,059 (GRCm39) |
R111H |
probably damaging |
Het |
| Alg2 |
A |
G |
4: 47,471,563 (GRCm39) |
V415A |
probably benign |
Het |
| Alpk2 |
T |
C |
18: 65,482,184 (GRCm39) |
E141G |
probably benign |
Het |
| Ampd1 |
A |
C |
3: 102,988,413 (GRCm39) |
T115P |
probably damaging |
Het |
| Ankrd12 |
A |
G |
17: 66,291,632 (GRCm39) |
L1267P |
probably damaging |
Het |
| Arfgef3 |
A |
T |
10: 18,528,441 (GRCm39) |
S315R |
probably damaging |
Het |
| Atp10d |
A |
C |
5: 72,396,461 (GRCm39) |
D222A |
probably benign |
Het |
| B9d1 |
A |
G |
11: 61,398,461 (GRCm39) |
E47G |
probably damaging |
Het |
| Bag2 |
T |
C |
1: 33,785,968 (GRCm39) |
D118G |
probably damaging |
Het |
| Bnip3l |
G |
T |
14: 67,246,208 (GRCm39) |
P9Q |
probably damaging |
Het |
| Casp8ap2 |
A |
G |
4: 32,639,807 (GRCm39) |
N287S |
probably benign |
Het |
| Ccdc190 |
A |
G |
1: 169,761,465 (GRCm39) |
D189G |
probably damaging |
Het |
| Ccdc88a |
A |
G |
11: 29,413,210 (GRCm39) |
K583E |
probably damaging |
Het |
| Cd84 |
A |
T |
1: 171,700,315 (GRCm39) |
N144I |
probably damaging |
Het |
| Chrnd |
A |
G |
1: 87,119,293 (GRCm39) |
|
probably benign |
Het |
| Clca3b |
G |
T |
3: 144,550,273 (GRCm39) |
T224K |
probably benign |
Het |
| Crcp |
A |
G |
5: 130,088,603 (GRCm39) |
T119A |
probably damaging |
Het |
| Cul2 |
T |
C |
18: 3,431,013 (GRCm39) |
Y596H |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,610,715 (GRCm39) |
W356R |
probably damaging |
Het |
| Dnah7b |
T |
A |
1: 46,167,272 (GRCm39) |
V588D |
possibly damaging |
Het |
| Dock4 |
G |
T |
12: 40,718,436 (GRCm39) |
G245W |
probably damaging |
Het |
| Dpf3 |
A |
G |
12: 83,341,273 (GRCm39) |
I160T |
possibly damaging |
Het |
| Dstyk |
A |
G |
1: 132,361,875 (GRCm39) |
T102A |
probably benign |
Het |
| Eif3d |
A |
T |
15: 77,844,229 (GRCm39) |
L425* |
probably null |
Het |
| Elac2 |
A |
G |
11: 64,886,153 (GRCm39) |
E477G |
probably damaging |
Het |
| Ephb3 |
G |
A |
16: 21,033,745 (GRCm39) |
R23H |
possibly damaging |
Het |
| Exd1 |
C |
T |
2: 119,350,807 (GRCm39) |
A485T |
probably benign |
Het |
| Ext2 |
G |
A |
2: 93,626,112 (GRCm39) |
T316I |
probably benign |
Het |
| Fbf1 |
A |
G |
11: 116,039,777 (GRCm39) |
V694A |
probably benign |
Het |
| Fgg |
G |
A |
3: 82,915,677 (GRCm39) |
|
probably benign |
Het |
| Flnb |
G |
A |
14: 7,919,238 (GRCm38) |
V1664I |
probably benign |
Het |
| Flnc |
G |
A |
6: 29,455,166 (GRCm39) |
D1932N |
probably damaging |
Het |
| Gm1818 |
A |
T |
12: 48,602,409 (GRCm39) |
|
noncoding transcript |
Het |
| Gnai1 |
G |
A |
5: 18,496,470 (GRCm39) |
S151L |
probably damaging |
Het |
| Golph3l |
G |
A |
3: 95,499,059 (GRCm39) |
R67H |
possibly damaging |
Het |
| Grk5 |
T |
A |
19: 60,976,213 (GRCm39) |
C42* |
probably null |
Het |
| Herc1 |
G |
A |
9: 66,404,625 (GRCm39) |
|
probably null |
Het |
| Hey2 |
A |
T |
10: 30,710,179 (GRCm39) |
H191Q |
possibly damaging |
Het |
| Il11 |
A |
G |
7: 4,779,481 (GRCm39) |
V8A |
probably benign |
Het |
| Il23r |
G |
A |
6: 67,408,635 (GRCm39) |
P402L |
probably benign |
Het |
| Irf5 |
A |
G |
6: 29,531,140 (GRCm39) |
N2S |
probably damaging |
Het |
| Lamb1 |
T |
C |
12: 31,348,929 (GRCm39) |
Y606H |
probably benign |
Het |
| Larp4b |
C |
T |
13: 9,220,934 (GRCm39) |
R650C |
probably damaging |
Het |
| Lrpap1 |
T |
C |
5: 35,259,765 (GRCm39) |
E111G |
possibly damaging |
Het |
| Lrrc36 |
T |
A |
8: 106,181,862 (GRCm39) |
S388T |
probably benign |
Het |
| Med27 |
T |
C |
2: 29,267,950 (GRCm39) |
|
probably benign |
Het |
| Mrc1 |
T |
G |
2: 14,275,017 (GRCm39) |
D439E |
probably damaging |
Het |
| Notch4 |
A |
T |
17: 34,789,034 (GRCm39) |
E444D |
probably damaging |
Het |
| Nrm |
G |
A |
17: 36,175,082 (GRCm39) |
V137I |
possibly damaging |
Het |
| Nxpe5 |
T |
A |
5: 138,228,795 (GRCm39) |
L4Q |
possibly damaging |
Het |
| Obscn |
A |
G |
11: 58,977,496 (GRCm39) |
V2052A |
possibly damaging |
Het |
| Oc90 |
A |
T |
15: 65,753,408 (GRCm39) |
Y304N |
probably damaging |
Het |
| Or13f5 |
T |
C |
4: 52,826,138 (GRCm39) |
V247A |
probably damaging |
Het |
| Or52d3 |
T |
A |
7: 104,229,180 (GRCm39) |
F109Y |
possibly damaging |
Het |
| Or5p1 |
T |
C |
7: 107,916,677 (GRCm39) |
V192A |
probably benign |
Het |
| Or8b101 |
T |
C |
9: 38,020,036 (GRCm39) |
I13T |
probably damaging |
Het |
| Or8k1 |
T |
A |
2: 86,047,877 (GRCm39) |
H59L |
possibly damaging |
Het |
| Parp10 |
A |
T |
15: 76,127,281 (GRCm39) |
I52N |
probably benign |
Het |
| Pdgfrb |
C |
A |
18: 61,206,315 (GRCm39) |
R608S |
probably damaging |
Het |
| Pecam1 |
A |
G |
11: 106,590,634 (GRCm39) |
C47R |
probably damaging |
Het |
| Pirb |
C |
T |
7: 3,720,602 (GRCm39) |
G299S |
probably benign |
Het |
| Pkhd1l1 |
A |
G |
15: 44,392,801 (GRCm39) |
E1712G |
possibly damaging |
Het |
| Plce1 |
T |
C |
19: 38,757,943 (GRCm39) |
I1958T |
probably damaging |
Het |
| Plch2 |
C |
T |
4: 155,069,092 (GRCm39) |
R1073Q |
probably benign |
Het |
| Pld5 |
A |
C |
1: 176,102,433 (GRCm39) |
I3S |
probably benign |
Het |
| Polr1a |
T |
C |
6: 71,943,385 (GRCm39) |
W1207R |
possibly damaging |
Het |
| Polr2m |
T |
G |
9: 71,391,050 (GRCm39) |
I51L |
possibly damaging |
Het |
| Ppl |
G |
A |
16: 4,922,790 (GRCm39) |
R234C |
probably damaging |
Het |
| Ppp1r42 |
C |
T |
1: 10,069,636 (GRCm39) |
R142H |
probably benign |
Het |
| Prokr1 |
A |
G |
6: 87,558,224 (GRCm39) |
V387A |
probably benign |
Het |
| Prss23 |
A |
T |
7: 89,159,108 (GRCm39) |
Y320* |
probably null |
Het |
| Ptprk |
A |
T |
10: 28,436,050 (GRCm39) |
M804L |
probably damaging |
Het |
| Rdh16f2 |
A |
G |
10: 127,710,823 (GRCm39) |
S147G |
probably benign |
Het |
| Rgs7bp |
T |
C |
13: 105,189,532 (GRCm39) |
H89R |
possibly damaging |
Het |
| Rilpl2 |
G |
T |
5: 124,607,875 (GRCm39) |
T115K |
possibly damaging |
Het |
| Rnf212 |
G |
A |
5: 108,877,334 (GRCm39) |
S153F |
probably damaging |
Het |
| Rnf213 |
A |
G |
11: 119,307,455 (GRCm39) |
D705G |
possibly damaging |
Het |
| Selenbp2 |
A |
G |
3: 94,611,426 (GRCm39) |
N379S |
probably benign |
Het |
| Sema3e |
G |
A |
5: 14,276,654 (GRCm39) |
V312M |
probably damaging |
Het |
| Sh2d5 |
T |
A |
4: 137,985,566 (GRCm39) |
L338Q |
probably damaging |
Het |
| Shank3 |
A |
G |
15: 89,384,402 (GRCm39) |
|
probably benign |
Het |
| Skor2 |
G |
T |
18: 76,948,113 (GRCm39) |
G612C |
probably damaging |
Het |
| Slc22a16 |
A |
G |
10: 40,449,636 (GRCm39) |
Y24C |
probably damaging |
Het |
| Slc4a1ap |
T |
A |
5: 31,688,053 (GRCm39) |
Y312* |
probably null |
Het |
| Slc5a7 |
A |
T |
17: 54,583,827 (GRCm39) |
F488I |
probably benign |
Het |
| Snrnp200 |
A |
G |
2: 127,053,527 (GRCm39) |
D130G |
probably damaging |
Het |
| Sorbs2 |
T |
A |
8: 46,194,652 (GRCm39) |
|
probably benign |
Het |
| Tmem91 |
T |
G |
7: 25,368,803 (GRCm39) |
T161P |
probably damaging |
Het |
| Tpd52l1 |
G |
A |
10: 31,222,697 (GRCm39) |
T99M |
probably damaging |
Het |
| Trps1 |
A |
G |
15: 50,524,073 (GRCm39) |
*1036Q |
probably null |
Het |
| Tshr |
A |
T |
12: 91,504,564 (GRCm39) |
T501S |
probably damaging |
Het |
| Tubgcp3 |
T |
C |
8: 12,721,987 (GRCm39) |
N15S |
probably benign |
Het |
| Unc5b |
A |
G |
10: 60,608,127 (GRCm39) |
S669P |
possibly damaging |
Het |
| Zfp970 |
A |
G |
2: 177,167,146 (GRCm39) |
E240G |
probably damaging |
Het |
|
| Other mutations in Dlc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Dlc1
|
APN |
8 |
37,037,436 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00807:Dlc1
|
APN |
8 |
37,040,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00924:Dlc1
|
APN |
8 |
37,405,368 (GRCm39) |
missense |
probably benign |
|
|
IGL01349:Dlc1
|
APN |
8 |
37,050,978 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01419:Dlc1
|
APN |
8 |
37,317,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01871:Dlc1
|
APN |
8 |
37,317,334 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Dlc1
|
APN |
8 |
37,317,345 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02525:Dlc1
|
APN |
8 |
37,046,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Dlc1
|
APN |
8 |
37,041,326 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02826:Dlc1
|
APN |
8 |
37,037,429 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03029:Dlc1
|
APN |
8 |
37,038,416 (GRCm39) |
splice site |
probably null |
|
|
BB001:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB011:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Dlc1
|
UTSW |
8 |
37,051,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0218:Dlc1
|
UTSW |
8 |
37,317,383 (GRCm39) |
missense |
probably benign |
|
|
R0419:Dlc1
|
UTSW |
8 |
37,050,740 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0513:Dlc1
|
UTSW |
8 |
37,051,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Dlc1
|
UTSW |
8 |
37,041,203 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R0646:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R0727:Dlc1
|
UTSW |
8 |
37,039,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Dlc1
|
UTSW |
8 |
37,405,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1061:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R1221:Dlc1
|
UTSW |
8 |
37,051,985 (GRCm39) |
missense |
probably benign |
|
|
R1440:Dlc1
|
UTSW |
8 |
37,060,617 (GRCm39) |
splice site |
probably benign |
|
|
R1501:Dlc1
|
UTSW |
8 |
37,405,302 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1606:Dlc1
|
UTSW |
8 |
37,317,406 (GRCm39) |
missense |
probably benign |
|
|
R1707:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1750:Dlc1
|
UTSW |
8 |
37,325,244 (GRCm39) |
splice site |
probably null |
|
|
R1762:Dlc1
|
UTSW |
8 |
37,404,739 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2041:Dlc1
|
UTSW |
8 |
37,049,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2055:Dlc1
|
UTSW |
8 |
37,060,535 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2091:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2987:Dlc1
|
UTSW |
8 |
37,041,306 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4285:Dlc1
|
UTSW |
8 |
37,041,282 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4294:Dlc1
|
UTSW |
8 |
37,051,907 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4631:Dlc1
|
UTSW |
8 |
37,404,712 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4867:Dlc1
|
UTSW |
8 |
37,051,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4902:Dlc1
|
UTSW |
8 |
37,044,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Dlc1
|
UTSW |
8 |
37,051,647 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5068:Dlc1
|
UTSW |
8 |
37,405,184 (GRCm39) |
missense |
probably benign |
|
|
R5198:Dlc1
|
UTSW |
8 |
37,405,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5471:Dlc1
|
UTSW |
8 |
37,051,879 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5668:Dlc1
|
UTSW |
8 |
37,404,655 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Dlc1
|
UTSW |
8 |
37,405,829 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R6323:Dlc1
|
UTSW |
8 |
37,405,537 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6655:Dlc1
|
UTSW |
8 |
37,039,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6908:Dlc1
|
UTSW |
8 |
37,404,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6914:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R6942:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R7269:Dlc1
|
UTSW |
8 |
37,046,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7271:Dlc1
|
UTSW |
8 |
37,049,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7462:Dlc1
|
UTSW |
8 |
37,405,118 (GRCm39) |
missense |
unknown |
|
|
R7548:Dlc1
|
UTSW |
8 |
37,051,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7649:Dlc1
|
UTSW |
8 |
37,049,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7960:Dlc1
|
UTSW |
8 |
37,404,989 (GRCm39) |
missense |
probably benign |
|
|
R7984:Dlc1
|
UTSW |
8 |
37,405,472 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8227:Dlc1
|
UTSW |
8 |
37,039,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8491:Dlc1
|
UTSW |
8 |
37,052,000 (GRCm39) |
missense |
probably benign |
|
|
R8526:Dlc1
|
UTSW |
8 |
37,404,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8715:Dlc1
|
UTSW |
8 |
37,405,795 (GRCm39) |
start gained |
probably benign |
|
|
R8887:Dlc1
|
UTSW |
8 |
37,051,481 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8972:Dlc1
|
UTSW |
8 |
37,405,394 (GRCm39) |
nonsense |
probably null |
|
|
R8988:Dlc1
|
UTSW |
8 |
37,039,997 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9031:Dlc1
|
UTSW |
8 |
37,405,055 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9080:Dlc1
|
UTSW |
8 |
37,052,006 (GRCm39) |
missense |
probably benign |
|
|
R9092:Dlc1
|
UTSW |
8 |
37,199,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9096:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9097:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Dlc1
|
UTSW |
8 |
37,066,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9187:Dlc1
|
UTSW |
8 |
37,405,786 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9240:Dlc1
|
UTSW |
8 |
37,052,005 (GRCm39) |
missense |
probably benign |
|
|
R9276:Dlc1
|
UTSW |
8 |
37,046,558 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9325:Dlc1
|
UTSW |
8 |
37,038,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Dlc1
|
UTSW |
8 |
37,051,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACTTTTAGGGTGACACTTCAG -3'
(R):5'- CAGAAGGCATTTTGTTACCTATGTG -3'
Sequencing Primer
(F):5'- ACTCCAATAGTCTTCTTTACACACTG -3'
(R):5'- ACCTATGTGATACTGAGTTCCTG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation