Incidental Mutation 'R4888:Mrc2'
| ID |
377124 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
042493-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4888 (G1)
|
| Quality Score |
211 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 105232034 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 862
(V862A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021038
AA Change: V862A
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
AA Change: V862A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100335
AA Change: V862A
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
AA Change: V862A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151135
|
| Meta Mutation Damage Score |
0.5166 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
99% (150/151) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 139 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931403M11Rik |
C |
A |
14: 24,671,419 (GRCm39) |
|
noncoding transcript |
Het |
| Abca7 |
A |
G |
10: 79,838,562 (GRCm39) |
K612R |
probably damaging |
Het |
| Adamtsl3 |
T |
C |
7: 82,223,822 (GRCm39) |
V275A |
possibly damaging |
Het |
| Afg3l1 |
G |
A |
8: 124,215,065 (GRCm39) |
|
probably null |
Het |
| Ajm1 |
G |
A |
2: 25,469,759 (GRCm39) |
R51C |
possibly damaging |
Het |
| Alcam |
T |
A |
16: 52,089,176 (GRCm39) |
H508L |
probably benign |
Het |
| Ankrd45 |
G |
A |
1: 160,982,942 (GRCm39) |
R151H |
probably damaging |
Het |
| Aqr |
G |
A |
2: 113,980,990 (GRCm39) |
L264F |
probably damaging |
Het |
| Arfgef2 |
G |
A |
2: 166,677,533 (GRCm39) |
A53T |
probably damaging |
Het |
| Arhgap30 |
A |
G |
1: 171,236,880 (GRCm39) |
T1085A |
probably benign |
Het |
| Atp10a |
T |
C |
7: 58,435,055 (GRCm39) |
V314A |
probably damaging |
Het |
| Bdp1 |
T |
C |
13: 100,187,627 (GRCm39) |
D1580G |
probably benign |
Het |
| Btbd17 |
T |
A |
11: 114,684,917 (GRCm39) |
T41S |
possibly damaging |
Het |
| Cacna1c |
T |
C |
6: 118,728,400 (GRCm39) |
N378S |
probably damaging |
Het |
| Camsap1 |
G |
T |
2: 25,825,562 (GRCm39) |
Q1375K |
probably benign |
Het |
| Catsper2 |
G |
T |
2: 121,227,604 (GRCm39) |
|
probably null |
Het |
| Cblif |
A |
G |
19: 11,729,583 (GRCm39) |
T181A |
probably benign |
Het |
| Ccar1 |
A |
G |
10: 62,588,997 (GRCm39) |
S829P |
unknown |
Het |
| Ccdc180 |
T |
C |
4: 45,909,308 (GRCm39) |
L492P |
probably damaging |
Het |
| Ccser2 |
A |
T |
14: 36,662,343 (GRCm39) |
N280K |
probably damaging |
Het |
| Cd37 |
T |
C |
7: 44,883,359 (GRCm39) |
D271G |
probably damaging |
Het |
| Cdcp1 |
G |
A |
9: 123,011,194 (GRCm39) |
|
probably benign |
Het |
| Cemip2 |
T |
C |
19: 21,833,528 (GRCm39) |
V1322A |
probably benign |
Het |
| Cep85 |
T |
A |
4: 133,892,062 (GRCm39) |
|
probably benign |
Het |
| Cfi |
C |
T |
3: 129,666,726 (GRCm39) |
P483L |
probably damaging |
Het |
| Csmd1 |
A |
G |
8: 15,945,674 (GRCm39) |
|
probably benign |
Het |
| Cytl1 |
G |
T |
5: 37,892,918 (GRCm39) |
L9F |
unknown |
Het |
| Defb26 |
T |
C |
2: 152,350,085 (GRCm39) |
E65G |
possibly damaging |
Het |
| Degs1 |
G |
A |
1: 182,104,370 (GRCm39) |
T305I |
probably damaging |
Het |
| Dnttip2 |
T |
G |
3: 122,070,241 (GRCm39) |
C485W |
probably damaging |
Het |
| Ecel1 |
G |
A |
1: 87,076,449 (GRCm39) |
|
probably benign |
Het |
| Edrf1 |
G |
T |
7: 133,260,339 (GRCm39) |
M83I |
probably damaging |
Het |
| Elmo2 |
A |
T |
2: 165,137,209 (GRCm39) |
C562S |
probably benign |
Het |
| Etl4 |
T |
A |
2: 20,344,922 (GRCm39) |
|
probably null |
Het |
| F2r |
A |
C |
13: 95,740,905 (GRCm39) |
V210G |
probably damaging |
Het |
| Fam171a1 |
T |
A |
2: 3,224,546 (GRCm39) |
V179E |
probably damaging |
Het |
| Fmod |
G |
T |
1: 133,967,977 (GRCm39) |
V6F |
possibly damaging |
Het |
| Foxr2 |
A |
G |
X: 151,913,312 (GRCm39) |
Q61R |
probably damaging |
Het |
| Gabra4 |
G |
A |
5: 71,729,546 (GRCm39) |
H76Y |
probably benign |
Het |
| Gck |
A |
T |
11: 5,859,150 (GRCm39) |
M139K |
possibly damaging |
Het |
| Gm10192 |
C |
G |
4: 97,071,345 (GRCm39) |
S20T |
probably null |
Het |
| Gm44501 |
T |
C |
17: 40,887,515 (GRCm39) |
L11P |
unknown |
Het |
| Gm572 |
T |
C |
4: 148,751,302 (GRCm39) |
|
probably null |
Het |
| Gnas |
A |
G |
2: 174,139,882 (GRCm39) |
K17R |
possibly damaging |
Het |
| Grm2 |
T |
A |
9: 106,527,865 (GRCm39) |
S340C |
probably damaging |
Het |
| Gsc |
T |
A |
12: 104,438,274 (GRCm39) |
H198L |
probably damaging |
Het |
| H2-Q3 |
A |
T |
17: 35,578,424 (GRCm39) |
|
noncoding transcript |
Het |
| H4c1 |
T |
C |
13: 23,944,935 (GRCm39) |
D69G |
probably damaging |
Het |
| Hivep3 |
A |
G |
4: 119,980,131 (GRCm39) |
E1723G |
probably damaging |
Het |
| Hk3 |
A |
T |
13: 55,154,405 (GRCm39) |
L757Q |
probably damaging |
Het |
| Homer2 |
A |
T |
7: 81,299,311 (GRCm39) |
D51E |
probably benign |
Het |
| Ier3ip1 |
T |
A |
18: 77,027,227 (GRCm39) |
|
probably benign |
Het |
| Itch |
T |
A |
2: 155,059,897 (GRCm39) |
|
probably null |
Het |
| Kalrn |
T |
A |
16: 33,991,700 (GRCm39) |
Q974L |
probably damaging |
Het |
| Kirrel3 |
G |
T |
9: 34,924,601 (GRCm39) |
G296W |
probably damaging |
Het |
| Klhl17 |
A |
G |
4: 156,315,082 (GRCm39) |
V525A |
probably benign |
Het |
| Klhl9 |
T |
C |
4: 88,640,182 (GRCm39) |
K20E |
probably benign |
Het |
| Kmt2a |
G |
T |
9: 44,732,977 (GRCm39) |
|
probably benign |
Het |
| Krt17 |
C |
A |
11: 100,147,305 (GRCm39) |
V409L |
probably benign |
Het |
| Lmx1b |
T |
C |
2: 33,454,802 (GRCm39) |
N322S |
probably benign |
Het |
| Lrrc63 |
G |
C |
14: 75,363,406 (GRCm39) |
P242A |
probably benign |
Het |
| Ltk |
T |
C |
2: 119,583,708 (GRCm39) |
N256D |
probably damaging |
Het |
| Map3k19 |
T |
A |
1: 127,745,470 (GRCm39) |
E1328V |
probably damaging |
Het |
| Map4k2 |
C |
T |
19: 6,394,033 (GRCm39) |
A280V |
probably benign |
Het |
| Micall1 |
C |
T |
15: 79,016,048 (GRCm39) |
R802* |
probably null |
Het |
| Mmp14 |
A |
G |
14: 54,673,662 (GRCm39) |
R109G |
probably damaging |
Het |
| Mmp27 |
A |
T |
9: 7,581,369 (GRCm39) |
H544L |
probably benign |
Het |
| Mpeg1 |
A |
G |
19: 12,440,434 (GRCm39) |
T631A |
probably damaging |
Het |
| Mpnd |
A |
G |
17: 56,318,641 (GRCm39) |
M217V |
probably benign |
Het |
| Mug2 |
T |
A |
6: 122,058,154 (GRCm39) |
S1239T |
probably damaging |
Het |
| Myb |
T |
A |
10: 21,002,137 (GRCm39) |
M616L |
probably benign |
Het |
| Myo18b |
A |
T |
5: 113,022,346 (GRCm39) |
|
probably benign |
Het |
| Myo1c |
C |
A |
11: 75,560,053 (GRCm39) |
T703N |
probably damaging |
Het |
| Myt1l |
T |
G |
12: 29,936,138 (GRCm39) |
C909G |
unknown |
Het |
| Nbea |
T |
C |
3: 55,912,776 (GRCm39) |
S1004G |
possibly damaging |
Het |
| Neb |
T |
C |
2: 52,186,319 (GRCm39) |
N918D |
probably benign |
Het |
| Nrtn |
T |
C |
17: 57,058,636 (GRCm39) |
T122A |
probably damaging |
Het |
| Nsd3 |
A |
T |
8: 26,188,939 (GRCm39) |
S1042C |
probably damaging |
Het |
| Ntmt2 |
A |
T |
1: 163,530,633 (GRCm39) |
C269S |
probably benign |
Het |
| Nvl |
A |
G |
1: 180,945,191 (GRCm39) |
L461S |
probably damaging |
Het |
| Onecut2 |
A |
T |
18: 64,473,998 (GRCm39) |
H183L |
possibly damaging |
Het |
| Or13p5 |
A |
C |
4: 118,591,885 (GRCm39) |
H53P |
probably benign |
Het |
| Or2h2 |
G |
A |
17: 37,396,343 (GRCm39) |
T238I |
probably damaging |
Het |
| Or4d10 |
C |
G |
19: 12,051,679 (GRCm39) |
G106R |
probably damaging |
Het |
| Or52e4 |
A |
G |
7: 104,705,689 (GRCm39) |
T79A |
possibly damaging |
Het |
| Or5c1 |
T |
G |
2: 37,222,601 (GRCm39) |
F281V |
probably damaging |
Het |
| Or6c1b |
A |
C |
10: 129,273,248 (GRCm39) |
D189A |
possibly damaging |
Het |
| Or6z5 |
A |
T |
7: 6,477,612 (GRCm39) |
I168F |
probably damaging |
Het |
| Pcdhb21 |
G |
T |
18: 37,648,130 (GRCm39) |
V420F |
possibly damaging |
Het |
| Pcdhb9 |
G |
A |
18: 37,536,286 (GRCm39) |
G760D |
probably benign |
Het |
| Pglyrp2 |
G |
A |
17: 32,637,771 (GRCm39) |
P86S |
probably benign |
Het |
| Phyhip |
T |
A |
14: 70,704,765 (GRCm39) |
V328E |
probably damaging |
Het |
| Pitpnb |
A |
T |
5: 111,530,862 (GRCm39) |
K218N |
possibly damaging |
Het |
| Pitrm1 |
A |
G |
13: 6,628,596 (GRCm39) |
D963G |
probably damaging |
Het |
| Pmfbp1 |
A |
G |
8: 110,258,792 (GRCm39) |
Y699C |
probably damaging |
Het |
| Pmpcb |
T |
A |
5: 21,945,660 (GRCm39) |
|
probably benign |
Het |
| Polg |
A |
T |
7: 79,114,353 (GRCm39) |
W203R |
probably damaging |
Het |
| Pramel22 |
A |
G |
4: 143,380,971 (GRCm39) |
S351P |
probably benign |
Het |
| Prss41 |
A |
T |
17: 24,055,977 (GRCm39) |
M252K |
probably benign |
Het |
| Prss46 |
A |
T |
9: 110,673,618 (GRCm39) |
M1L |
possibly damaging |
Het |
| Rimklb |
T |
C |
6: 122,441,051 (GRCm39) |
|
probably null |
Het |
| Rngtt |
T |
C |
4: 33,500,335 (GRCm39) |
I556T |
unknown |
Het |
| Rock1 |
A |
C |
18: 10,122,698 (GRCm39) |
D374E |
probably benign |
Het |
| Rspry1 |
C |
A |
8: 95,385,417 (GRCm39) |
H450N |
probably benign |
Het |
| Rusc2 |
T |
C |
4: 43,423,942 (GRCm39) |
V1032A |
probably damaging |
Het |
| Sacs |
A |
G |
14: 61,449,647 (GRCm39) |
R3898G |
probably damaging |
Het |
| Scnn1b |
A |
T |
7: 121,502,110 (GRCm39) |
H256L |
probably benign |
Het |
| Sh3gl2 |
T |
A |
4: 85,297,494 (GRCm39) |
H157Q |
probably benign |
Het |
| Sipa1l1 |
C |
A |
12: 82,389,107 (GRCm39) |
S444R |
probably damaging |
Het |
| Sntg1 |
T |
A |
1: 8,433,818 (GRCm39) |
I478F |
probably damaging |
Het |
| Spata31e2 |
A |
G |
1: 26,722,628 (GRCm39) |
Y851H |
probably benign |
Het |
| Sptb |
G |
T |
12: 76,655,811 (GRCm39) |
L1424M |
probably benign |
Het |
| Sry |
T |
A |
Y: 2,663,105 (GRCm39) |
H185L |
unknown |
Het |
| Stox2 |
T |
G |
8: 47,656,198 (GRCm39) |
T93P |
probably damaging |
Het |
| Tatdn2 |
T |
A |
6: 113,681,566 (GRCm39) |
F472Y |
possibly damaging |
Het |
| Tefm |
A |
T |
11: 80,031,185 (GRCm39) |
V17D |
possibly damaging |
Het |
| Tekt2 |
G |
T |
4: 126,218,460 (GRCm39) |
T70N |
probably benign |
Het |
| Ticam1 |
T |
C |
17: 56,578,642 (GRCm39) |
D151G |
probably damaging |
Het |
| Tmem63c |
A |
G |
12: 87,136,139 (GRCm39) |
E785G |
probably damaging |
Het |
| Tnmd |
A |
T |
X: 132,765,551 (GRCm39) |
N219I |
probably benign |
Het |
| Ttc14 |
T |
A |
3: 33,861,024 (GRCm39) |
L407* |
probably null |
Het |
| Ttll7 |
T |
C |
3: 146,599,932 (GRCm39) |
M1T |
probably null |
Het |
| Ttn |
T |
A |
2: 76,746,835 (GRCm39) |
|
probably null |
Het |
| Uchl1 |
T |
C |
5: 66,833,780 (GRCm39) |
M12T |
probably benign |
Het |
| Uggt2 |
A |
T |
14: 119,315,062 (GRCm39) |
|
probably null |
Het |
| Uggt2 |
T |
C |
14: 119,286,665 (GRCm39) |
T224A |
probably damaging |
Het |
| Umodl1 |
A |
G |
17: 31,218,175 (GRCm39) |
E1254G |
probably damaging |
Het |
| Unc5d |
A |
G |
8: 29,156,927 (GRCm39) |
F773L |
probably benign |
Het |
| Unc80 |
C |
A |
1: 66,683,606 (GRCm39) |
P2216Q |
probably damaging |
Het |
| Usp40 |
T |
A |
1: 87,913,923 (GRCm39) |
|
probably null |
Het |
| Vmn1r117 |
A |
T |
7: 20,617,421 (GRCm39) |
M209K |
probably damaging |
Het |
| Vmn2r44 |
A |
T |
7: 8,380,985 (GRCm39) |
W303R |
probably benign |
Het |
| Wnk2 |
G |
A |
13: 49,224,478 (GRCm39) |
R268C |
probably damaging |
Het |
| Wnt2 |
T |
C |
6: 18,023,125 (GRCm39) |
K175E |
possibly damaging |
Het |
| Xkr6 |
T |
C |
14: 64,056,953 (GRCm39) |
V288A |
unknown |
Het |
| Zfp125 |
A |
G |
12: 20,950,459 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp512b |
A |
C |
2: 181,228,856 (GRCm39) |
V703G |
probably damaging |
Het |
| Zglp1 |
A |
T |
9: 20,973,957 (GRCm39) |
I243N |
probably benign |
Het |
| Zgpat |
T |
C |
2: 181,020,651 (GRCm39) |
S275P |
probably benign |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2267:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4610:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4611:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4707:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7038:Mrc2
|
UTSW |
11 |
105,223,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGGTTTATCTTTGCAAGCCATTTG -3'
(R):5'- TCACTCTCCAAGGTGTGCAG -3'
Sequencing Primer
(F):5'- GCAAGCCATTTGTTGCAGC -3'
(R):5'- AAGGTGTGCAGGCCGATC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation