Incidental Mutation 'R5439:Or10g1b'
ID 428545
Institutional Source Beutler Lab
Gene Symbol Or10g1b
Ensembl Gene ENSMUSG00000063867
Gene Name olfactory receptor family 10 subfamily G member 1B
Synonyms Olfr1511, GA_x6K02T2RJGY-608749-609705, MOR223-9
MMRRC Submission 043004-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5439 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 52627272-52628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 52627582 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 216 (F216S)
Ref Sequence ENSEMBL: ENSMUSP00000149479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078171] [ENSMUST00000214168]
AlphaFold E9PWU0
Predicted Effect probably damaging
Transcript: ENSMUST00000078171
AA Change: F216S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077302
Gene: ENSMUSG00000063867
AA Change: F216S

DomainStartEndE-ValueType
Pfam:7tm_4 35 310 1.3e-50 PFAM
Pfam:7tm_1 45 293 2.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214168
AA Change: F216S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 A T 4: 144,504,683 (GRCm39) I156N probably damaging Het
Abca1 C A 4: 53,042,381 (GRCm39) R1897L possibly damaging Het
Ablim2 A G 5: 36,015,170 (GRCm39) K461E probably damaging Het
Acss3 A T 10: 106,773,008 (GRCm39) Y659* probably null Het
Actr8 T G 14: 29,708,952 (GRCm39) L253R probably damaging Het
Arid4b A G 13: 14,362,281 (GRCm39) K915R probably damaging Het
C3 T C 17: 57,511,502 (GRCm39) E1560G probably benign Het
Cacna1c A T 6: 118,631,333 (GRCm39) I1013N probably damaging Het
Cep83 G A 10: 94,625,600 (GRCm39) R670H probably benign Het
Col19a1 T A 1: 24,332,193 (GRCm39) D870V probably damaging Het
Ddr2 A G 1: 169,832,298 (GRCm39) V164A possibly damaging Het
Dnaaf10 A G 11: 17,162,031 (GRCm39) D23G possibly damaging Het
Donson A T 16: 91,476,814 (GRCm39) V549E probably damaging Het
Egflam C T 15: 7,254,144 (GRCm39) G824R probably damaging Het
Extl3 A G 14: 65,292,075 (GRCm39) F916S probably damaging Het
Fam110c A G 12: 31,124,406 (GRCm39) M123V unknown Het
G3bp1 A T 11: 55,388,813 (GRCm39) I342F probably damaging Het
Golgb1 A G 16: 36,720,870 (GRCm39) N409D probably benign Het
Grin2b C T 6: 135,713,304 (GRCm39) G859D probably damaging Het
Hspb1 A T 5: 135,918,186 (GRCm39) T178S probably benign Het
Iigp1 A G 18: 60,523,329 (GRCm39) Y149C probably damaging Het
Il22 G T 10: 118,045,366 (GRCm39) G159* probably null Het
Jcad T C 18: 4,675,790 (GRCm39) F1184S probably damaging Het
Kcnj2 G T 11: 110,963,057 (GRCm39) V150L probably damaging Het
Kifc1 C T 17: 34,105,639 (GRCm39) R56Q probably damaging Het
Lce1h A G 3: 92,671,027 (GRCm39) S42P unknown Het
Lrp4 C A 2: 91,327,418 (GRCm39) D1471E probably benign Het
Lrrc3 C A 10: 77,737,299 (GRCm39) V46L probably benign Het
Mcf2l G A 8: 12,976,646 (GRCm39) A2T possibly damaging Het
Med12l G A 3: 59,170,634 (GRCm39) C1673Y probably null Het
Nckap1 T C 2: 80,343,034 (GRCm39) E955G possibly damaging Het
Ndufs3 T A 2: 90,732,690 (GRCm39) probably null Het
Nkx6-1 A G 5: 101,809,698 (GRCm39) probably null Het
Obscn C A 11: 58,890,954 (GRCm39) E1713* probably null Het
Or10ak12 G A 4: 118,666,560 (GRCm39) T167I possibly damaging Het
Or10n1 A G 9: 39,524,916 (GRCm39) T18A probably benign Het
Or2n1 T A 17: 38,486,917 (GRCm39) probably null Het
Or6n1 A G 1: 173,917,541 (GRCm39) R312G probably benign Het
Or7e165 A C 9: 19,695,161 (GRCm39) H244P probably damaging Het
Or8c15 A G 9: 38,121,050 (GRCm39) T234A probably benign Het
Osbpl5 A G 7: 143,295,433 (GRCm39) F10L possibly damaging Het
Plvap A C 8: 71,964,095 (GRCm39) I89S probably damaging Het
Ppp2r2a A G 14: 67,259,772 (GRCm39) V308A possibly damaging Het
Ppp2r5e T C 12: 75,540,250 (GRCm39) S132G probably benign Het
Pum3 G T 19: 27,389,659 (GRCm39) Q398K probably benign Het
Ralgapa2 T C 2: 146,184,430 (GRCm39) T1526A probably benign Het
Sh3tc2 T A 18: 62,122,704 (GRCm39) Y488* probably null Het
Spmip7 A T 11: 11,440,244 (GRCm39) R8S possibly damaging Het
Sqle A G 15: 59,202,753 (GRCm39) Y537C probably benign Het
Sult2a8 T G 7: 14,159,439 (GRCm39) K60T probably damaging Het
Tex15 T C 8: 34,064,199 (GRCm39) S1210P possibly damaging Het
Thumpd3 A G 6: 113,043,825 (GRCm39) silent Het
Timeless A G 10: 128,077,604 (GRCm39) D228G probably damaging Het
Trim31 A T 17: 37,216,797 (GRCm39) probably null Het
Ttc39c A T 18: 12,828,428 (GRCm39) D196V possibly damaging Het
Wbp4 C A 14: 79,709,837 (GRCm39) V133L possibly damaging Het
Zfp354c G T 11: 50,706,597 (GRCm39) D159E probably benign Het
Zfp940 C A 7: 29,544,858 (GRCm39) D350Y probably benign Het
Other mutations in Or10g1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02614:Or10g1b APN 14 52,627,627 (GRCm39) missense probably damaging 0.99
IGL02645:Or10g1b APN 14 52,627,958 (GRCm39) missense possibly damaging 0.50
R0277:Or10g1b UTSW 14 52,627,846 (GRCm39) missense probably damaging 1.00
R0601:Or10g1b UTSW 14 52,627,283 (GRCm39) nonsense probably null
R1956:Or10g1b UTSW 14 52,628,037 (GRCm39) missense probably benign 0.06
R2342:Or10g1b UTSW 14 52,627,322 (GRCm39) missense possibly damaging 0.89
R5193:Or10g1b UTSW 14 52,628,069 (GRCm39) missense probably benign 0.00
R5506:Or10g1b UTSW 14 52,628,084 (GRCm39) missense probably damaging 1.00
R6948:Or10g1b UTSW 14 52,627,614 (GRCm39) missense probably benign 0.22
R8191:Or10g1b UTSW 14 52,627,987 (GRCm39) missense probably benign 0.00
R8267:Or10g1b UTSW 14 52,627,903 (GRCm39) missense probably damaging 1.00
R8503:Or10g1b UTSW 14 52,627,354 (GRCm39) missense probably damaging 0.97
X0035:Or10g1b UTSW 14 52,627,823 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- GCAACTGCTCCATCAAAGGG -3'
(R):5'- TTGTGCACAATTCTAGTGGCTG -3'

Sequencing Primer
(F):5'- TGCTCCATCAAAGGGACTCTTGG -3'
(R):5'- CACAATTCTAGTGGCTGGAGCTTG -3'
Posted On 2016-09-01