Incidental Mutation 'R5681:Cux1'
| ID |
443030 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.892)
|
| Stock # |
R5681 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 136337038 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 696
(W696R)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000175998]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000176778]
[ENSMUST00000177297]
[ENSMUST00000176745]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000004097
AA Change: W734R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: W734R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148082
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175975
AA Change: W812R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: W812R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176172
AA Change: W825R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: W825R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176216
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176486
AA Change: W696R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
AA Change: W696R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176778
AA Change: W817R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: W817R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177297
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 97.0%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acoxl |
T |
C |
2: 127,814,559 (GRCm39) |
F45S |
possibly damaging |
Het |
| Adora2b |
T |
A |
11: 62,140,067 (GRCm39) |
V47E |
probably damaging |
Het |
| Amdhd2 |
A |
G |
17: 24,375,014 (GRCm39) |
I396T |
probably damaging |
Het |
| Arhgap5 |
G |
A |
12: 52,566,562 (GRCm39) |
D1178N |
probably benign |
Het |
| Atp10d |
T |
C |
5: 72,404,289 (GRCm39) |
|
probably benign |
Het |
| Baiap3 |
A |
G |
17: 25,468,347 (GRCm39) |
S264P |
probably damaging |
Het |
| Brinp3 |
A |
T |
1: 146,777,484 (GRCm39) |
I644F |
probably benign |
Het |
| Ccdc168 |
A |
T |
1: 44,100,624 (GRCm39) |
V158D |
possibly damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,208,698 (GRCm39) |
R675G |
probably benign |
Het |
| Cnr2 |
T |
G |
4: 135,644,000 (GRCm39) |
M26R |
probably damaging |
Het |
| Col6a2 |
A |
T |
10: 76,445,085 (GRCm39) |
|
probably null |
Het |
| D6Ertd527e |
A |
G |
6: 87,088,188 (GRCm39) |
N117S |
unknown |
Het |
| Dnah12 |
T |
C |
14: 26,537,452 (GRCm39) |
C2234R |
probably benign |
Het |
| Dnhd1 |
G |
A |
7: 105,352,416 (GRCm39) |
R2523Q |
probably damaging |
Het |
| Dock2 |
T |
G |
11: 34,199,836 (GRCm39) |
I1405L |
probably benign |
Het |
| Dsg1c |
T |
C |
18: 20,416,270 (GRCm39) |
F724L |
probably damaging |
Het |
| Elapor2 |
T |
A |
5: 9,509,308 (GRCm39) |
|
probably null |
Het |
| Enoph1 |
T |
C |
5: 100,210,136 (GRCm39) |
|
probably null |
Het |
| Epha10 |
A |
T |
4: 124,796,359 (GRCm39) |
Q356L |
unknown |
Het |
| Fbln2 |
G |
T |
6: 91,248,778 (GRCm39) |
V1148L |
probably damaging |
Het |
| Firrm |
T |
C |
1: 163,789,654 (GRCm39) |
N627S |
probably damaging |
Het |
| Gp2 |
C |
T |
7: 119,051,517 (GRCm39) |
V233M |
possibly damaging |
Het |
| Gtf2ird1 |
T |
A |
5: 134,392,172 (GRCm39) |
S800C |
probably damaging |
Het |
| Hat1 |
A |
G |
2: 71,264,553 (GRCm39) |
|
probably null |
Het |
| Hpdl |
A |
T |
4: 116,678,039 (GRCm39) |
S141T |
probably benign |
Het |
| Klhl29 |
A |
G |
12: 5,140,669 (GRCm39) |
S658P |
possibly damaging |
Het |
| Lifr |
T |
A |
15: 7,220,565 (GRCm39) |
I1065N |
probably damaging |
Het |
| Lrrn2 |
G |
T |
1: 132,864,899 (GRCm39) |
|
probably benign |
Het |
| Marchf9 |
T |
A |
10: 126,894,172 (GRCm39) |
I144F |
probably benign |
Het |
| Mtnr1a |
A |
G |
8: 45,540,974 (GRCm39) |
I312V |
possibly damaging |
Het |
| Ngf |
T |
A |
3: 102,427,669 (GRCm39) |
F139L |
probably damaging |
Het |
| Nipbl |
T |
C |
15: 8,330,866 (GRCm39) |
I2318V |
probably benign |
Het |
| Nkpd1 |
C |
T |
7: 19,257,498 (GRCm39) |
Q276* |
probably null |
Het |
| Nphs1 |
A |
G |
7: 30,186,050 (GRCm39) |
D1227G |
probably benign |
Het |
| Olfm3 |
C |
A |
3: 114,915,924 (GRCm39) |
N285K |
probably benign |
Het |
| Or1j1 |
C |
A |
2: 36,702,693 (GRCm39) |
S137I |
probably benign |
Het |
| Or4f60 |
T |
A |
2: 111,902,722 (GRCm39) |
I69F |
probably benign |
Het |
| Or7g35 |
G |
A |
9: 19,496,195 (GRCm39) |
D121N |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,091 (GRCm39) |
Y259H |
probably damaging |
Het |
| Or8b39 |
C |
T |
9: 37,996,927 (GRCm39) |
S265F |
possibly damaging |
Het |
| Osbp2 |
A |
G |
11: 3,813,486 (GRCm39) |
S128P |
probably benign |
Het |
| Otop2 |
A |
T |
11: 115,217,685 (GRCm39) |
M174L |
probably damaging |
Het |
| Pard3 |
A |
G |
8: 128,115,914 (GRCm39) |
T668A |
possibly damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,617,685 (GRCm39) |
T967A |
possibly damaging |
Het |
| Pls1 |
A |
G |
9: 95,669,065 (GRCm39) |
V52A |
probably damaging |
Het |
| Ptcd3 |
T |
C |
6: 71,884,643 (GRCm39) |
K64R |
probably damaging |
Het |
| Pxn |
T |
C |
5: 115,682,593 (GRCm39) |
W69R |
possibly damaging |
Het |
| Rai14 |
T |
C |
15: 10,575,206 (GRCm39) |
D584G |
probably damaging |
Het |
| Safb |
G |
A |
17: 56,906,000 (GRCm39) |
|
probably benign |
Het |
| Serinc2 |
A |
C |
4: 130,158,869 (GRCm39) |
L10R |
probably damaging |
Het |
| Serpinb12 |
A |
T |
1: 106,874,431 (GRCm39) |
H52L |
probably benign |
Het |
| Serpinb9h |
G |
A |
13: 33,579,812 (GRCm39) |
C20Y |
probably damaging |
Het |
| Serpinf2 |
A |
G |
11: 75,326,765 (GRCm39) |
Y273H |
probably damaging |
Het |
| Slc2a10 |
T |
A |
2: 165,356,660 (GRCm39) |
S107T |
probably benign |
Het |
| Slc41a3 |
T |
C |
6: 90,617,928 (GRCm39) |
L318P |
probably damaging |
Het |
| Slc6a3 |
A |
T |
13: 73,686,854 (GRCm39) |
I74F |
probably damaging |
Het |
| Snrnp200 |
G |
A |
2: 127,067,055 (GRCm39) |
G788D |
probably damaging |
Het |
| Snx7 |
A |
G |
3: 117,640,272 (GRCm39) |
I79T |
probably benign |
Het |
| Sox11 |
G |
T |
12: 27,391,823 (GRCm39) |
D195E |
probably benign |
Het |
| Ssc4d |
A |
G |
5: 135,999,074 (GRCm39) |
L43P |
probably damaging |
Het |
| Tab2 |
A |
G |
10: 7,795,837 (GRCm39) |
I215T |
probably damaging |
Het |
| Ttn |
C |
T |
2: 76,660,942 (GRCm39) |
V7422I |
possibly damaging |
Het |
| Unc13c |
A |
T |
9: 73,453,357 (GRCm39) |
|
probably null |
Het |
| Wdr17 |
T |
C |
8: 55,115,904 (GRCm39) |
D633G |
probably damaging |
Het |
| Wdsub1 |
A |
T |
2: 59,683,239 (GRCm39) |
M445K |
probably damaging |
Het |
| Xpc |
A |
G |
6: 91,481,102 (GRCm39) |
F257L |
probably damaging |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCTGGGGTGTCTCACTGC -3'
(R):5'- TGCTATCTCCCTGAAGAAAACC -3'
Sequencing Primer
(F):5'- TCCAGTGAGGCTCAGCTCTG -3'
(R):5'- CCCTGCAGCACCTGAGAC -3'
|
| Posted On |
2016-11-09 |
Incidental Mutation