Incidental Mutation 'R6350:Mras'
ID 514156
Institutional Source Beutler Lab
Gene Symbol Mras
Ensembl Gene ENSMUSG00000032470
Gene Name muscle and microspikes RAS
Synonyms 2900078C09Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R6350 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 99267473-99319434 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99293560 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 27 (S27G)
Ref Sequence ENSEMBL: ENSMUSP00000121307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035045] [ENSMUST00000119472] [ENSMUST00000122384] [ENSMUST00000123771]
AlphaFold O08989
Predicted Effect probably damaging
Transcript: ENSMUST00000035045
AA Change: S27G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035045
Gene: ENSMUSG00000032470
AA Change: S27G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119472
AA Change: S27G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112407
Gene: ENSMUSG00000032470
AA Change: S27G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000122384
AA Change: S27G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113275
Gene: ENSMUSG00000032470
AA Change: S27G

DomainStartEndE-ValueType
RAS 11 178 4.26e-114 SMART
low complexity region 182 191 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000123771
AA Change: S27G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121307
Gene: ENSMUSG00000032470
AA Change: S27G

DomainStartEndE-ValueType
RAS 11 130 1.06e-68 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for an insertional mutation that inactivates the gene exhibit a decreased mean percentage of peripheral blood B cells but no other evidence of morphological or neurological defects; mutant astrocytes display normal responsiveness to different trophic factors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,947,764 (GRCm39) K554E possibly damaging Het
Acsf2 T C 11: 94,449,156 (GRCm39) M609V probably benign Het
Acsm3 A G 7: 119,367,256 (GRCm39) T30A probably benign Het
Adam32 T C 8: 25,353,445 (GRCm39) K715E possibly damaging Het
Cdk5r1 T C 11: 80,369,068 (GRCm39) L245P probably damaging Het
Cntn3 A G 6: 102,147,579 (GRCm39) V926A probably damaging Het
Csf2rb G A 15: 78,229,752 (GRCm39) D440N probably damaging Het
D3Ertd751e T A 3: 41,708,278 (GRCm39) H138Q probably damaging Het
D630003M21Rik A G 2: 158,062,415 (GRCm39) L35P probably damaging Het
Faap100 A T 11: 120,265,406 (GRCm39) V490E probably damaging Het
Il3ra A G 14: 14,348,903 (GRCm38) D99G probably benign Het
Kcnmb1 A G 11: 33,914,711 (GRCm39) K4R probably damaging Het
Larp1 T A 11: 57,940,657 (GRCm39) D594E probably benign Het
Lnpep G T 17: 17,783,071 (GRCm39) H577N probably benign Het
Mief1 T C 15: 80,133,804 (GRCm39) I287T probably damaging Het
Myh7b T A 2: 155,470,680 (GRCm39) C1043S probably benign Het
N4bp1 T C 8: 87,588,596 (GRCm39) D114G probably damaging Het
Nsmce4a A T 7: 130,140,829 (GRCm39) I219K probably damaging Het
Nynrin A T 14: 56,105,533 (GRCm39) I848F probably benign Het
Or2p2 T C 13: 21,256,775 (GRCm39) E232G probably benign Het
Or4f62 T A 2: 111,986,542 (GRCm39) I82N probably damaging Het
Patj T A 4: 98,293,855 (GRCm39) S36T probably benign Het
Pcdhb15 G A 18: 37,608,414 (GRCm39) V549M probably damaging Het
Prl2c5 T C 13: 13,357,631 (GRCm39) probably null Het
Ptbp3 A T 4: 59,482,624 (GRCm39) D386E probably damaging Het
Ptpra T C 2: 130,382,512 (GRCm39) L451P probably damaging Het
Repin1 A G 6: 48,574,562 (GRCm39) D497G probably damaging Het
Ryr2 A G 13: 11,776,282 (GRCm39) F1085S probably damaging Het
Slc6a18 G A 13: 73,826,044 (GRCm39) A2V possibly damaging Het
Wee2 C T 6: 40,432,039 (GRCm39) R203C probably damaging Het
Zmynd15 T C 11: 70,355,257 (GRCm39) V388A probably damaging Het
Other mutations in Mras
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01759:Mras APN 9 99,293,548 (GRCm39) missense probably damaging 1.00
R3918:Mras UTSW 9 99,293,473 (GRCm39) missense probably damaging 1.00
R3919:Mras UTSW 9 99,293,473 (GRCm39) missense probably damaging 1.00
R3981:Mras UTSW 9 99,293,469 (GRCm39) missense probably damaging 1.00
R4950:Mras UTSW 9 99,276,537 (GRCm39) missense probably damaging 1.00
R5375:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R5501:Mras UTSW 9 99,293,599 (GRCm39) missense probably damaging 1.00
R5624:Mras UTSW 9 99,293,538 (GRCm39) missense probably damaging 0.99
R6349:Mras UTSW 9 99,276,669 (GRCm39) missense probably damaging 1.00
R7453:Mras UTSW 9 99,271,793 (GRCm39) missense probably benign 0.01
R8351:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R8451:Mras UTSW 9 99,293,548 (GRCm39) missense probably damaging 1.00
R9622:Mras UTSW 9 99,275,054 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGTTGCCCCACTAAAACCTC -3'
(R):5'- GACCATGCGTGACAAAGCTC -3'

Sequencing Primer
(F):5'- TAAAACCTCTCAAATTCCCCTGATC -3'
(R):5'- GGAGTCTGTGTTCCTCTATAAGACAC -3'
Posted On 2018-04-27