Incidental Mutation 'IGL01018:Oprm1'
| ID |
53830 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Oprm1
|
| Ensembl Gene |
ENSMUSG00000000766 |
| Gene Name |
opioid receptor, mu 1 |
| Synonyms |
MOP-R, MOR-1, MOP receptor, mor, Oprm, muOR |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.110)
|
| Stock # |
IGL01018
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
6708593-6988209 bp(+) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
T to C
at 6987170 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115413
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052751]
[ENSMUST00000063036]
[ENSMUST00000086896]
[ENSMUST00000105601]
[ENSMUST00000105611]
[ENSMUST00000105615]
[ENSMUST00000129954]
[ENSMUST00000154941]
[ENSMUST00000129221]
[ENSMUST00000144264]
|
| AlphaFold |
P42866 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052751
|
| SMART Domains |
Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.2e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063036
|
| SMART Domains |
Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
8.7e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086896
|
| SMART Domains |
Protein: ENSMUSP00000084110
Gene: ENSMUSG00000064065
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PH
|
3 |
65 |
7.4e-8 |
PFAM |
|
low complexity region
|
85 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
210 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105601
|
| SMART Domains |
Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1l9ha_
|
46 |
100 |
3e-9 |
SMART |
|
PDB:4DKL|A
|
52 |
100 |
3e-21 |
PDB |
|
low complexity region
|
119 |
131 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
184 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105611
|
| SMART Domains |
Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.4e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
4.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105615
|
| SMART Domains |
Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
24 |
268 |
1.3e-63 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000121411
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141897
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129954
|
| SMART Domains |
Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
338 |
6.9e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1.5e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
5.4e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154941
|
| SMART Domains |
Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
9.6e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
6.1e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2e-67 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129221
|
| SMART Domains |
Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
12 |
261 |
1.1e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
15 |
287 |
7.3e-11 |
PFAM |
|
Pfam:7tm_1
|
21 |
272 |
2.4e-67 |
PFAM |
|
low complexity region
|
340 |
351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144264
|
| SMART Domains |
Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
76 |
325 |
1.7e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
79 |
351 |
1e-10 |
PFAM |
|
Pfam:7tm_1
|
85 |
336 |
3.4e-67 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5530400C23Rik |
G |
T |
6: 133,271,460 (GRCm39) |
R168I |
probably benign |
Het |
| 5530400C23Rik |
A |
T |
6: 133,271,461 (GRCm39) |
R168S |
probably benign |
Het |
| Armt1 |
T |
A |
10: 4,400,732 (GRCm39) |
S160T |
probably benign |
Het |
| Armt1 |
C |
T |
10: 4,404,237 (GRCm39) |
|
probably benign |
Het |
| Ccdc170 |
T |
C |
10: 4,462,788 (GRCm39) |
W35R |
probably benign |
Het |
| Ccdc170 |
T |
C |
10: 4,464,114 (GRCm39) |
V31A |
probably benign |
Het |
| Ccdc170 |
G |
T |
10: 4,464,155 (GRCm39) |
A99S |
probably benign |
Het |
| Glp2r |
C |
A |
11: 67,600,470 (GRCm39) |
V460F |
probably benign |
Het |
| Gm21411 |
C |
T |
4: 146,977,067 (GRCm39) |
S69N |
possibly damaging |
Het |
| Gm21411 |
T |
C |
4: 146,977,034 (GRCm39) |
Q80R |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,418,856 (GRCm38) |
P24L |
probably benign |
Het |
| H2-M10.6 |
C |
T |
17: 37,123,112 (GRCm39) |
A15V |
probably benign |
Het |
| H60c |
T |
C |
10: 3,209,766 (GRCm39) |
M174V |
probably benign |
Het |
| H60c |
A |
C |
10: 3,210,343 (GRCm39) |
F69V |
probably benign |
Het |
| Ipcef1 |
G |
A |
10: 6,840,551 (GRCm39) |
A382V |
probably benign |
Het |
| Ipcef1 |
C |
T |
10: 6,869,968 (GRCm39) |
R144Q |
probably damaging |
Het |
| Mapk8ip3 |
T |
G |
17: 25,118,693 (GRCm39) |
|
probably benign |
Het |
| Mthfd1l |
T |
C |
10: 3,928,708 (GRCm39) |
V100A |
probably benign |
Het |
| Mthfd1l |
T |
C |
10: 3,957,800 (GRCm39) |
V279A |
probably benign |
Het |
| Mthfd1l |
T |
C |
10: 3,982,345 (GRCm39) |
|
probably benign |
Het |
| Mtrf1l |
A |
G |
10: 5,764,180 (GRCm39) |
|
probably benign |
Het |
| Myo18b |
T |
C |
5: 112,957,613 (GRCm39) |
E1450G |
probably damaging |
Het |
| Obscn |
C |
T |
11: 59,018,895 (GRCm39) |
V973M |
probably damaging |
Het |
| Or6p1 |
G |
A |
1: 174,258,908 (GRCm39) |
V305I |
probably benign |
Het |
| Pou5f2 |
A |
G |
13: 78,174,057 (GRCm39) |
|
probably benign |
Het |
| Ralgapa2 |
G |
A |
2: 146,252,113 (GRCm39) |
H891Y |
probably benign |
Het |
| Ralgapa2 |
T |
G |
2: 146,252,112 (GRCm39) |
H806P |
probably benign |
Het |
| Rmnd1 |
A |
G |
10: 4,377,392 (GRCm39) |
W96R |
probably benign |
Het |
| Rmnd1 |
A |
T |
10: 4,377,290 (GRCm39) |
S130T |
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,721,991 (GRCm39) |
E1063G |
probably damaging |
Het |
| Speer4a3 |
G |
T |
5: 26,155,721 (GRCm39) |
H208N |
probably benign |
Het |
| Trappc12 |
A |
C |
12: 28,741,853 (GRCm39) |
|
probably benign |
Het |
| Ulbp3 |
G |
A |
10: 3,075,031 (GRCm39) |
|
noncoding transcript |
Het |
| Ulbp3 |
C |
T |
10: 3,075,193 (GRCm39) |
|
noncoding transcript |
Het |
| Ulbp3 |
A |
G |
10: 3,070,231 (GRCm39) |
|
noncoding transcript |
Het |
| Ulbp3 |
A |
G |
10: 3,070,209 (GRCm39) |
|
noncoding transcript |
Het |
| Vip |
A |
G |
10: 5,592,480 (GRCm39) |
D40G |
probably benign |
Het |
| Vmn2r125 |
T |
C |
4: 156,702,907 (GRCm39) |
|
probably benign |
Het |
| Vmn2r125 |
A |
G |
4: 156,703,140 (GRCm39) |
N173D |
probably damaging |
Het |
| Vmn2r125 |
C |
A |
4: 156,703,194 (GRCm39) |
Q191K |
probably benign |
Het |
| Vmn2r125 |
A |
C |
4: 156,703,195 (GRCm39) |
Q191P |
probably benign |
Het |
| Vmn2r125 |
A |
T |
4: 156,703,332 (GRCm39) |
T237S |
probably benign |
Het |
| Vmn2r125 |
T |
A |
4: 156,703,521 (GRCm39) |
L300M |
probably benign |
Het |
| Vmn2r125 |
C |
T |
4: 156,703,333 (GRCm39) |
T237I |
probably benign |
Het |
| Vmn2r129 |
C |
A |
4: 156,690,730 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r129 |
A |
T |
4: 156,690,441 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r129 |
G |
A |
4: 156,686,900 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r129 |
T |
C |
4: 156,687,885 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r129 |
T |
C |
4: 156,686,558 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r40 |
G |
A |
7: 8,911,175 (GRCm39) |
S706F |
probably damaging |
Het |
| Zfp14 |
T |
A |
7: 29,737,526 (GRCm39) |
R486S |
probably damaging |
Het |
|
| Other mutations in Oprm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01768:Oprm1
|
APN |
10 |
6,779,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Oprm1
|
APN |
10 |
6,780,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03391:Oprm1
|
APN |
10 |
6,964,077 (GRCm39) |
intron |
probably benign |
|
|
IGL03410:Oprm1
|
APN |
10 |
6,780,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Oprm1
|
UTSW |
10 |
6,779,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0189:Oprm1
|
UTSW |
10 |
6,739,071 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0321:Oprm1
|
UTSW |
10 |
6,779,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Oprm1
|
UTSW |
10 |
6,782,604 (GRCm39) |
splice site |
probably null |
|
|
R0730:Oprm1
|
UTSW |
10 |
6,782,652 (GRCm39) |
intron |
probably benign |
|
|
R1542:Oprm1
|
UTSW |
10 |
6,738,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1743:Oprm1
|
UTSW |
10 |
6,780,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1874:Oprm1
|
UTSW |
10 |
6,739,035 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2864:Oprm1
|
UTSW |
10 |
6,744,226 (GRCm39) |
splice site |
probably null |
|
|
R2964:Oprm1
|
UTSW |
10 |
6,738,914 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3792:Oprm1
|
UTSW |
10 |
6,789,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4008:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R4049:Oprm1
|
UTSW |
10 |
6,779,087 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4088:Oprm1
|
UTSW |
10 |
6,780,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4724:Oprm1
|
UTSW |
10 |
6,708,656 (GRCm39) |
nonsense |
probably null |
|
|
R4812:Oprm1
|
UTSW |
10 |
6,782,698 (GRCm39) |
intron |
probably benign |
|
|
R4822:Oprm1
|
UTSW |
10 |
6,779,036 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4855:Oprm1
|
UTSW |
10 |
6,788,468 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5072:Oprm1
|
UTSW |
10 |
6,782,550 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5768:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Oprm1
|
UTSW |
10 |
6,739,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Oprm1
|
UTSW |
10 |
6,782,520 (GRCm39) |
missense |
probably benign |
|
|
R6327:Oprm1
|
UTSW |
10 |
6,780,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7135:Oprm1
|
UTSW |
10 |
6,780,203 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7413:Oprm1
|
UTSW |
10 |
6,778,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7455:Oprm1
|
UTSW |
10 |
6,780,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8192:Oprm1
|
UTSW |
10 |
6,788,417 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8210:Oprm1
|
UTSW |
10 |
6,780,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8945:Oprm1
|
UTSW |
10 |
6,782,644 (GRCm39) |
intron |
probably benign |
|
|
R9054:Oprm1
|
UTSW |
10 |
6,773,914 (GRCm39) |
intron |
probably benign |
|
|
R9723:Oprm1
|
UTSW |
10 |
6,788,514 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9726:Oprm1
|
UTSW |
10 |
6,929,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Oprm1
|
UTSW |
10 |
6,780,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2013-06-28 |
Incidental Mutation