Mutagenetix > Incidental Mutation

Incidental Mutation 'R7112:Dnah8'

551589

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

P1-Loop, Dnahc8, Hst6.7b

MMRRC Submission

045204-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.477) question?

Stock #

R7112 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

30845909-31094736 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 31090366 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 4623 (V4623I)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170651
AA Change: V4623I

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: V4623I

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak2	G	T	12: 112,747,747 (GRCm39)	A1036E		Het
Baz2b	A	T	2: 59,792,528 (GRCm39)	H533Q	possibly damaging	Het
Bcl2l11	T	A	2: 128,000,235 (GRCm39)	W193R	probably damaging	Het
Bcl2l12	C	T	7: 44,646,338 (GRCm39)	G24D	probably damaging	Het
Cacna1b	A	G	2: 24,580,773 (GRCm39)	V691A	probably damaging	Het
Cdh8	T	C	8: 99,922,984 (GRCm39)	D304G	probably damaging	Het
Ces3a	A	T	8: 105,784,594 (GRCm39)	Q525H	probably damaging	Het
Csmd1	C	A	8: 16,151,142 (GRCm39)	C1391F	probably damaging	Het
Cul7	G	T	17: 46,962,624 (GRCm39)	G85V	probably damaging	Het
Dnhd1	T	A	7: 105,363,192 (GRCm39)	L3918Q	probably damaging	Het
Exoc4	A	T	6: 33,898,423 (GRCm39)	N881Y	probably damaging	Het
Flt1	G	C	5: 147,540,379 (GRCm39)	A770G	probably damaging	Het
Fndc5	A	G	4: 129,035,915 (GRCm39)	N184S	probably benign	Het
Folh1	A	G	7: 86,424,845 (GRCm39)		probably null	Het
Frem3	A	T	8: 81,338,660 (GRCm39)	T318S	probably damaging	Het
Gba2	A	G	4: 43,568,453 (GRCm39)	V671A	probably benign	Het
Gpt2	G	A	8: 86,244,681 (GRCm39)	E325K	probably benign	Het
Jph2	G	A	2: 163,217,704 (GRCm39)	T324M	probably damaging	Het
Kank4	A	G	4: 98,649,758 (GRCm39)	V937A	probably damaging	Het
Kdm3a	T	A	6: 71,609,154 (GRCm39)	E24D	probably benign	Het
Kidins220	T	A	12: 25,054,018 (GRCm39)	L464Q	probably damaging	Het
Loxhd1	T	A	18: 77,476,210 (GRCm39)	V1159E	probably damaging	Het
Malrd1	A	G	2: 15,929,987 (GRCm39)	N1498D	unknown	Het
Mplkipl1	T	G	19: 61,163,997 (GRCm39)	D146A	probably damaging	Het
Mrgprb5	C	T	7: 47,818,655 (GRCm39)	V27I	probably benign	Het
Mtfr2	A	G	10: 20,233,312 (GRCm39)	N294D	probably damaging	Het
Muc6	A	T	7: 141,235,542 (GRCm39)	L498H	probably damaging	Het
N4bp2	A	G	5: 65,948,050 (GRCm39)	T227A	possibly damaging	Het
Nin	C	T	12: 70,149,573 (GRCm39)	R12Q		Het
Obscn	G	C	11: 58,920,151 (GRCm39)	A27G		Het
Or11h7	T	A	14: 50,891,583 (GRCm39)	D296E	probably benign	Het
Or4k5	T	G	14: 50,385,392 (GRCm39)	E313A	probably benign	Het
Or52r1b	G	A	7: 102,690,862 (GRCm39)	D54N	probably damaging	Het
Or8b48	T	A	9: 38,493,330 (GRCm39)	Y252*	probably null	Het
Or8s5	T	A	15: 98,238,421 (GRCm39)	M150L	possibly damaging	Het
Polr2a	A	G	11: 69,626,135 (GRCm39)	S1672P	unknown	Het
Qprt	A	G	7: 126,707,361 (GRCm39)	V245A	probably damaging	Het
Rab11fip5	T	A	6: 85,325,176 (GRCm39)	E377V	probably damaging	Het
Rere	A	G	4: 150,491,061 (GRCm39)	T71A	probably benign	Het
Ret	A	T	6: 118,174,063 (GRCm39)	L11Q	possibly damaging	Het
Rp1	C	T	1: 4,419,241 (GRCm39)	V624I	probably benign	Het
Scaf8	T	A	17: 3,213,304 (GRCm39)	L131H	unknown	Het
Scgb2a2	A	G	19: 9,829,021 (GRCm39)	R58G	probably benign	Het
Scn11a	A	G	9: 119,583,875 (GRCm39)	I1580T	probably damaging	Het
Slco4c1	T	G	1: 96,768,866 (GRCm39)	K332T	probably damaging	Het
Sntg1	T	G	1: 8,518,289 (GRCm39)	Y368S	possibly damaging	Het
Stim1	A	G	7: 102,057,615 (GRCm39)	T143A	probably benign	Het
Tbr1	A	G	2: 61,642,160 (GRCm39)	D475G	probably benign	Het
Tcp1	A	G	17: 13,136,760 (GRCm39)	D47G	probably damaging	Het
Tpgs2	T	C	18: 25,282,194 (GRCm39)	D119G	probably damaging	Het
Trim40	C	A	17: 37,193,534 (GRCm39)	R225M	probably null	Het
Tro	GCAGTGCTTGGTCCTCCGAAGCCACCTCCAGTGCTTGGTCCTCCGAAGCCACCTCCAGTGCTTGGTCCTCCAAAGCCACCTCCAGTGCTTGGTCCTCCAAAGCCACCTCCAGTATTTGGTCCTCCAAAGCCACCTCCAGTGCTTGGTCC	GCAGTGCTTGGTCCTCCAAAGCCACCTCCAGTGCTTGGTCCTCCAAAGCCACCTCCAGTATTTGGTCCTCCAAAGCCACCTCCAGTGCTTGGTCC	X: 149,428,852 (GRCm39)		probably benign	Het
Trpm1	A	T	7: 63,885,593 (GRCm39)	N870Y	probably damaging	Het
Tsr3	A	G	17: 25,459,445 (GRCm39)	D47G	probably benign	Het
Vil1	G	A	1: 74,455,161 (GRCm39)	G38R	probably damaging	Het
Vmn2r91	A	T	17: 18,325,880 (GRCm39)	Q166L	possibly damaging	Het
Wdr33	C	T	18: 32,026,056 (GRCm39)	T919I	unknown	Het
Wdr36	T	C	18: 32,972,504 (GRCm39)	V64A	probably benign	Het
Xpnpep1	T	C	19: 52,998,538 (GRCm39)	I237V	probably benign	Het
Zfp780b	A	T	7: 27,662,566 (GRCm39)	I663N	probably damaging	Het
Zfyve9	G	A	4: 108,507,519 (GRCm39)	A513V	probably benign	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,896,150 (GRCm39)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	31,074,904 (GRCm39)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	31,034,677 (GRCm39)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,882,452 (GRCm39)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,875,615 (GRCm39)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,986,880 (GRCm39)	nonsense	probably null
IGL00840:Dnah8	APN	17	31,009,915 (GRCm39)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	31,038,250 (GRCm39)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,925,431 (GRCm39)	nonsense	probably null
IGL00976:Dnah8	APN	17	31,070,684 (GRCm39)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,854,979 (GRCm39)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,902,688 (GRCm39)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,867,459 (GRCm39)	missense	probably benign
IGL01723:Dnah8	APN	17	30,927,445 (GRCm39)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,970,565 (GRCm39)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,955,115 (GRCm39)	missense	probably benign
IGL01958:Dnah8	APN	17	31,074,869 (GRCm39)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,875,572 (GRCm39)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,936,854 (GRCm39)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,867,391 (GRCm39)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,925,487 (GRCm39)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,868,747 (GRCm39)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,978,588 (GRCm39)	missense	probably benign
IGL02263:Dnah8	APN	17	30,948,139 (GRCm39)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,932,021 (GRCm39)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,966,231 (GRCm39)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	31,013,770 (GRCm39)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	31,049,819 (GRCm39)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	31,037,025 (GRCm39)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,919,387 (GRCm39)	missense	probably benign
IGL02455:Dnah8	APN	17	30,891,308 (GRCm39)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,887,269 (GRCm39)	missense	probably benign
IGL02831:Dnah8	APN	17	30,931,250 (GRCm39)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,988,671 (GRCm39)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,940,084 (GRCm39)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,923,809 (GRCm39)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,965,735 (GRCm39)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,937,980 (GRCm39)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,905,347 (GRCm39)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,961,754 (GRCm39)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	31,003,118 (GRCm39)	missense	probably benign
IGL03176:Dnah8	APN	17	30,913,011 (GRCm39)	missense	probably benign
IGL03191:Dnah8	APN	17	30,945,804 (GRCm39)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	31,034,639 (GRCm39)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,892,894 (GRCm39)	splice site	probably null
IGL03255:Dnah8	APN	17	30,960,355 (GRCm39)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,891,323 (GRCm39)	missense	probably benign
IGL03348:Dnah8	APN	17	30,965,960 (GRCm39)	missense	probably damaging	0.99
Alternator	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
armature	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
Brush	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
Dynos	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
joule	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
solenoid	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,854,437 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,451 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,439 (GRCm39)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,882,428 (GRCm39)	missense	probably benign
P0029:Dnah8	UTSW	17	30,984,694 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,927,419 (GRCm39)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,882,290 (GRCm39)	missense	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,974,093 (GRCm39)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	31,003,064 (GRCm39)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0184:Dnah8	UTSW	17	30,902,657 (GRCm39)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,909,245 (GRCm39)	missense	probably benign
R0268:Dnah8	UTSW	17	30,988,681 (GRCm39)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,955,130 (GRCm39)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	31,090,325 (GRCm39)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,920,955 (GRCm39)	missense	probably benign
R0470:Dnah8	UTSW	17	30,927,514 (GRCm39)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,974,054 (GRCm39)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R0499:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,937,935 (GRCm39)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,927,332 (GRCm39)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,903,147 (GRCm39)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,955,129 (GRCm39)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,923,636 (GRCm39)	missense	probably benign
R0843:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	31,022,217 (GRCm39)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,892,894 (GRCm39)	splice site	probably null
R1102:Dnah8	UTSW	17	31,073,738 (GRCm39)	splice site	probably null
R1137:Dnah8	UTSW	17	31,074,910 (GRCm39)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,939,974 (GRCm39)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,956,269 (GRCm39)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	31,059,596 (GRCm39)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,971,049 (GRCm39)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,892,862 (GRCm39)	missense	probably benign
R1541:Dnah8	UTSW	17	30,966,221 (GRCm39)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,854,638 (GRCm39)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,944,098 (GRCm39)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	31,073,914 (GRCm39)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,988,625 (GRCm39)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,941,911 (GRCm39)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,927,381 (GRCm39)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,903,160 (GRCm39)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,950,154 (GRCm39)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,854,479 (GRCm39)	missense	unknown
R1935:Dnah8	UTSW	17	30,945,870 (GRCm39)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,950,181 (GRCm39)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,931,359 (GRCm39)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,950,133 (GRCm39)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,977,255 (GRCm39)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,854,632 (GRCm39)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,956,232 (GRCm39)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,872,367 (GRCm39)	missense	probably benign
R2180:Dnah8	UTSW	17	31,059,621 (GRCm39)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	31,013,718 (GRCm39)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,990,846 (GRCm39)	missense	probably benign
R2357:Dnah8	UTSW	17	31,093,909 (GRCm39)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,896,178 (GRCm39)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	31,070,705 (GRCm39)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,960,339 (GRCm39)	nonsense	probably null
R2509:Dnah8	UTSW	17	30,994,019 (GRCm39)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	31,052,542 (GRCm39)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,958,631 (GRCm39)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,958,622 (GRCm39)	nonsense	probably null
R3747:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3748:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3749:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,974,015 (GRCm39)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,889,621 (GRCm39)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,882,396 (GRCm39)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	31,073,911 (GRCm39)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,913,039 (GRCm39)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,988,813 (GRCm39)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,967,533 (GRCm39)	missense	probably benign
R4326:Dnah8	UTSW	17	30,971,066 (GRCm39)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,944,072 (GRCm39)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,971,120 (GRCm39)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	31,032,125 (GRCm39)	missense	probably benign
R4475:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,919,380 (GRCm39)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,881,026 (GRCm39)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,970,541 (GRCm39)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,903,211 (GRCm39)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,902,608 (GRCm39)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,944,140 (GRCm39)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	31,070,721 (GRCm39)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,986,898 (GRCm39)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,965,949 (GRCm39)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	31,059,688 (GRCm39)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	31,038,113 (GRCm39)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,948,116 (GRCm39)	missense	probably benign
R4969:Dnah8	UTSW	17	30,941,988 (GRCm39)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,882,275 (GRCm39)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	31,006,159 (GRCm39)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,955,070 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	31,019,505 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,958,731 (GRCm39)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,950,012 (GRCm39)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	31,029,327 (GRCm39)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,984,571 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,931,269 (GRCm39)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,965,739 (GRCm39)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	31,009,891 (GRCm39)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R5358:Dnah8	UTSW	17	30,965,928 (GRCm39)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	31,019,521 (GRCm39)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	31,009,930 (GRCm39)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,971,890 (GRCm39)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,925,360 (GRCm39)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	31,022,082 (GRCm39)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	31,019,561 (GRCm39)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,956,307 (GRCm39)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	31,022,235 (GRCm39)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	31,029,298 (GRCm39)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,937,981 (GRCm39)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,909,235 (GRCm39)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	31,093,978 (GRCm39)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,947,165 (GRCm39)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,875,659 (GRCm39)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	31,034,638 (GRCm39)	nonsense	probably null
R5986:Dnah8	UTSW	17	31,070,604 (GRCm39)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,882,279 (GRCm39)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,966,239 (GRCm39)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,966,828 (GRCm39)	nonsense	probably null
R6239:Dnah8	UTSW	17	31,029,333 (GRCm39)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
R6443:Dnah8	UTSW	17	30,990,859 (GRCm39)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,882,266 (GRCm39)	splice site	probably null
R6765:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,854,640 (GRCm39)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,984,698 (GRCm39)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,867,439 (GRCm39)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,960,147 (GRCm39)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,929,525 (GRCm39)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,965,933 (GRCm39)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	31,013,633 (GRCm39)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,986,899 (GRCm39)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,958,712 (GRCm39)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,881,065 (GRCm39)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,862,249 (GRCm39)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,923,698 (GRCm39)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
R7146:Dnah8	UTSW	17	30,988,618 (GRCm39)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,863,591 (GRCm39)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	31,093,988 (GRCm39)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	31,003,099 (GRCm39)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,986,939 (GRCm39)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,923,743 (GRCm39)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,925,363 (GRCm39)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	31,006,165 (GRCm39)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,994,077 (GRCm39)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	31,004,081 (GRCm39)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,868,651 (GRCm39)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,876,947 (GRCm39)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	31,074,918 (GRCm39)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R7866:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,882,348 (GRCm39)	missense	probably benign
R7891:Dnah8	UTSW	17	30,931,263 (GRCm39)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,960,311 (GRCm39)	nonsense	probably null
R8076:Dnah8	UTSW	17	31,003,127 (GRCm39)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,892,797 (GRCm39)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	31,090,393 (GRCm39)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8270:Dnah8	UTSW	17	31,059,687 (GRCm39)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,984,701 (GRCm39)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,988,805 (GRCm39)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8348:Dnah8	UTSW	17	30,955,121 (GRCm39)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,862,234 (GRCm39)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,914,152 (GRCm39)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8459:Dnah8	UTSW	17	30,944,221 (GRCm39)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,875,603 (GRCm39)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,940,108 (GRCm39)	missense	probably benign
R8524:Dnah8	UTSW	17	30,934,472 (GRCm39)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,940,084 (GRCm39)	nonsense	probably null
R8698:Dnah8	UTSW	17	31,094,009 (GRCm39)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,960,289 (GRCm39)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,944,078 (GRCm39)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	31,013,712 (GRCm39)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,981,616 (GRCm39)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,927,286 (GRCm39)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	31,070,628 (GRCm39)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	31,009,807 (GRCm39)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,956,401 (GRCm39)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,975,729 (GRCm39)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,854,647 (GRCm39)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	31,004,071 (GRCm39)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,944,099 (GRCm39)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,990,857 (GRCm39)	missense	probably benign
R9347:Dnah8	UTSW	17	30,927,333 (GRCm39)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,872,361 (GRCm39)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	31,029,297 (GRCm39)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	31,049,777 (GRCm39)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,932,021 (GRCm39)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,932,029 (GRCm39)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,998,112 (GRCm39)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	31,037,115 (GRCm39)	missense	probably benign
R9789:Dnah8	UTSW	17	30,980,104 (GRCm39)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,854,450 (GRCm39)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,967,654 (GRCm39)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	31,038,160 (GRCm39)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,867,514 (GRCm39)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,932,069 (GRCm39)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,913,007 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- AGATGCCCTGAGTGTTACTTCC -3'
(R):5'- TTCACTGAGAGAGCCAAGGC -3'

Sequencing Primer
(F):5'- GAGTGTTACTTCCTCTGCGTTACTG -3'
(R):5'- GAGCCAAGGCCAGTTTTTAATTTTG -3'

Posted On

2019-05-15