Incidental Mutation 'PIT4382001:Tas2r118'
ID 554679
Institutional Source Beutler Lab
Gene Symbol Tas2r118
Ensembl Gene ENSMUSG00000043865
Gene Name taste receptor, type 2, member 118
Synonyms T2R18, mt2r40, mGR18, Tas2r18
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # PIT4382001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 23969160-23970059 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 23969785 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 92 (T92I)
Ref Sequence ENSEMBL: ENSMUSP00000053700 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062463]
AlphaFold P59529
Predicted Effect possibly damaging
Transcript: ENSMUST00000062463
AA Change: T92I

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000053700
Gene: ENSMUSG00000043865
AA Change: T92I

DomainStartEndE-ValueType
Pfam:TAS2R 1 297 4.6e-87 PFAM
Coding Region Coverage
  • 1x: 92.9%
  • 3x: 90.5%
  • 10x: 84.6%
  • 20x: 72.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430038I01Rik G T 7: 136,978,711 (GRCm39) H144N unknown Het
Acsm4 C T 7: 119,297,798 (GRCm39) T145M probably damaging Het
Adam10 T C 9: 70,673,363 (GRCm39) L498P probably damaging Het
Adgrl2 A G 3: 148,522,934 (GRCm39) L430P Het
Alk T C 17: 72,256,916 (GRCm39) M648V probably benign Het
Arhgap35 T C 7: 16,297,794 (GRCm39) R424G possibly damaging Het
Baiap2l1 T C 5: 144,215,480 (GRCm39) K342E possibly damaging Het
Ccdc54 C T 16: 50,411,219 (GRCm39) V16M probably damaging Het
Chil3 T G 3: 106,055,975 (GRCm39) D366A probably damaging Het
Chuk A G 19: 44,087,046 (GRCm39) V151A probably damaging Het
Cpd T G 11: 76,688,614 (GRCm39) H886P probably benign Het
Cped1 T A 6: 22,222,449 (GRCm39) C736* probably null Het
Creb3l3 T C 10: 80,920,746 (GRCm39) E428G probably benign Het
Csad G A 15: 102,097,085 (GRCm39) L7F probably benign Het
Dnah1 C T 14: 31,006,412 (GRCm39) D2255N probably damaging Het
Dnajb12 T C 10: 59,728,508 (GRCm39) Y159H probably damaging Het
Dpysl4 T A 7: 138,669,494 (GRCm39) Y57* probably null Het
F2rl1 T G 13: 95,650,154 (GRCm39) N243H probably benign Het
Fhl4 T C 10: 84,934,293 (GRCm39) K163E possibly damaging Het
Flot2 T C 11: 77,944,193 (GRCm39) S46P possibly damaging Het
Fsip2 C A 2: 82,821,196 (GRCm39) T5643K possibly damaging Het
Golga4 T A 9: 118,382,521 (GRCm39) Y542N possibly damaging Het
Il17re A G 6: 113,446,038 (GRCm39) T426A probably benign Het
Kdm2a T A 19: 4,393,201 (GRCm39) M385L probably benign Het
Kdm3b T C 18: 34,942,140 (GRCm39) S744P probably damaging Het
Krtap20-1 T A 16: 88,881,048 (GRCm39) Y26* probably null Het
Lama2 T C 10: 27,080,901 (GRCm39) D974G probably damaging Het
Ldc1 A T 4: 130,112,954 (GRCm39) N147K possibly damaging Het
Lipo5 A T 19: 33,443,339 (GRCm39) L159Q probably null Het
LTO1 T A 7: 144,470,181 (GRCm39) Y37N probably damaging Het
Mau2 C T 8: 70,483,302 (GRCm39) E187K possibly damaging Het
Mrpl9 T C 3: 94,355,136 (GRCm39) L236P probably benign Het
Mta1 A G 12: 113,096,870 (GRCm39) T564A probably benign Het
Mylk C T 16: 34,696,012 (GRCm39) S249L probably damaging Het
Ncor1 G T 11: 62,235,489 (GRCm39) T331K probably damaging Het
Nsun3 T A 16: 62,606,228 (GRCm39) K15N probably damaging Het
Nsun5 A G 5: 135,400,355 (GRCm39) Y132C probably benign Het
Obsl1 T A 1: 75,464,607 (GRCm39) T1605S probably benign Het
Or10a3n A G 7: 108,493,309 (GRCm39) Y107H probably damaging Het
Or51f1 A G 7: 102,505,809 (GRCm39) Y227H probably damaging Het
Or51t4 A T 7: 102,598,656 (GRCm39) Y328F probably benign Het
Or5b109 T C 19: 13,212,259 (GRCm39) I215T probably damaging Het
P2rx1 A G 11: 72,900,026 (GRCm39) N148D probably benign Het
Pogz T A 3: 94,787,107 (GRCm39) S1232T probably damaging Het
Polr3b C A 10: 84,520,049 (GRCm39) T655N probably damaging Het
Prss34 T C 17: 25,517,882 (GRCm39) probably null Het
Rhpn2 A G 7: 35,090,178 (GRCm39) probably null Het
Runx1 T A 16: 92,410,648 (GRCm39) D256V probably damaging Het
Shc1 C A 3: 89,334,715 (GRCm39) Q525K probably benign Het
Slc10a5 T C 3: 10,400,507 (GRCm39) D51G probably benign Het
Slc6a3 A T 13: 73,719,642 (GRCm39) N557I probably benign Het
Slmap C T 14: 26,254,586 (GRCm39) R32H probably damaging Het
Spata31d1c T C 13: 65,183,985 (GRCm39) I509T probably benign Het
Spata31e4 A T 13: 50,855,007 (GRCm39) E215V probably damaging Het
Srr C A 11: 74,801,134 (GRCm39) V138F probably benign Het
Tcaf2 A T 6: 42,601,300 (GRCm39) *920K probably null Het
Tenm2 T A 11: 35,954,729 (GRCm39) Y1141F probably damaging Het
Thoc6 T C 17: 23,887,841 (GRCm39) N322S probably benign Het
Tlcd2 A G 11: 75,359,417 (GRCm39) I70V probably benign Het
Tmem214 A G 5: 31,028,795 (GRCm39) D128G possibly damaging Het
Trav13d-4 T C 14: 53,995,238 (GRCm39) V64A probably benign Het
Tyro3 T C 2: 119,632,845 (GRCm39) W122R probably damaging Het
Ugcg A G 4: 59,213,246 (GRCm39) D144G possibly damaging Het
Uimc1 T C 13: 55,178,828 (GRCm39) D627G probably benign Het
Utp6 T C 11: 79,853,099 (GRCm39) I13V probably benign Het
Vmn2r99 A G 17: 19,614,605 (GRCm39) K775R probably damaging Het
Wdfy3 CG C 5: 102,030,827 (GRCm39) probably null Het
Zw10 C T 9: 48,982,944 (GRCm39) T525I probably benign Het
Other mutations in Tas2r118
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Tas2r118 APN 6 23,969,746 (GRCm39) missense probably damaging 0.99
IGL02517:Tas2r118 APN 6 23,969,891 (GRCm39) missense probably damaging 1.00
IGL03387:Tas2r118 APN 6 23,969,180 (GRCm39) missense possibly damaging 0.71
R0241:Tas2r118 UTSW 6 23,969,338 (GRCm39) missense probably damaging 1.00
R0241:Tas2r118 UTSW 6 23,969,338 (GRCm39) missense probably damaging 1.00
R0544:Tas2r118 UTSW 6 23,969,400 (GRCm39) missense probably damaging 0.97
R1438:Tas2r118 UTSW 6 23,969,422 (GRCm39) missense possibly damaging 0.79
R1471:Tas2r118 UTSW 6 23,969,170 (GRCm39) missense probably damaging 0.96
R1632:Tas2r118 UTSW 6 23,969,260 (GRCm39) missense probably benign 0.21
R2096:Tas2r118 UTSW 6 23,969,912 (GRCm39) missense possibly damaging 0.90
R2106:Tas2r118 UTSW 6 23,969,569 (GRCm39) missense probably benign
R2903:Tas2r118 UTSW 6 23,969,801 (GRCm39) missense possibly damaging 0.87
R2904:Tas2r118 UTSW 6 23,969,801 (GRCm39) missense possibly damaging 0.87
R2905:Tas2r118 UTSW 6 23,969,801 (GRCm39) missense possibly damaging 0.87
R3798:Tas2r118 UTSW 6 23,969,822 (GRCm39) missense possibly damaging 0.71
R4402:Tas2r118 UTSW 6 23,969,293 (GRCm39) missense probably benign 0.11
R4647:Tas2r118 UTSW 6 23,969,467 (GRCm39) missense probably damaging 1.00
R4707:Tas2r118 UTSW 6 23,969,225 (GRCm39) missense probably benign 0.26
R4965:Tas2r118 UTSW 6 23,969,627 (GRCm39) missense probably benign 0.41
R5114:Tas2r118 UTSW 6 23,969,209 (GRCm39) missense probably benign 0.05
R5823:Tas2r118 UTSW 6 23,969,470 (GRCm39) missense probably benign 0.04
R5834:Tas2r118 UTSW 6 23,969,876 (GRCm39) missense probably benign 0.06
R6976:Tas2r118 UTSW 6 23,969,470 (GRCm39) missense probably benign 0.04
R7335:Tas2r118 UTSW 6 23,969,749 (GRCm39) missense probably damaging 1.00
R8696:Tas2r118 UTSW 6 23,969,344 (GRCm39) missense probably damaging 1.00
R8966:Tas2r118 UTSW 6 23,970,020 (GRCm39) missense probably damaging 1.00
R9014:Tas2r118 UTSW 6 23,970,049 (GRCm39) missense probably benign 0.04
R9237:Tas2r118 UTSW 6 23,969,617 (GRCm39) missense probably benign 0.09
X0062:Tas2r118 UTSW 6 23,969,439 (GRCm39) missense probably damaging 1.00
Z1177:Tas2r118 UTSW 6 23,969,558 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCTAGGGTGACTAATTCCATCTGGATG -3'
(R):5'- GTTGCACAACGGTTGCAGTG -3'

Sequencing Primer
(F):5'- TGTGATATTTAACAACAGAAGGGATG -3'
(R):5'- CACAACGGTTGCAGTGCTATTCAG -3'
Posted On 2019-06-07