|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 118|
|Synonyms||mGR18, mt2r40, T2R18, Tas2r18|
|Is this an essential gene?||Probably non essential (E-score: 0.125)|
|Stock #||R1438 (G1)|
|Chromosomal Location||23969161-23970060 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 23969423 bp|
|Amino Acid Change||Histidine to Leucine at position 213 (H213L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000053700 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000062463]|
|Predicted Effect||possibly damaging
AA Change: H213L
PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
AA Change: H213L
|Meta Mutation Damage Score||0.06|
|Coding Region Coverage||
|Validation Efficiency||99% (80/81)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r118||
(F):5'- TGCCAATGCAAAGTCTCCTTACCC -3'
(R):5'- TGCTGTCCTCTACTGTGTCAAGGTC -3'
(F):5'- AATGCAGGGTTGCTCATCATC -3'
(R):5'- TCCTCTGGCTGAGGATGAAAATC -3'