Incidental Mutation 'R7319:Vmn2r68'
ID |
568060 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r68
|
Ensembl Gene |
ENSMUSG00000096861 |
Gene Name |
vomeronasal 2, receptor 68 |
Synonyms |
EG620697, Vmn2r68-ps |
MMRRC Submission |
045415-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.085)
|
Stock # |
R7319 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
84870726-84886912 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 84883042 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 237
(T237S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129411
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061074]
|
AlphaFold |
L7N2B3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000061074
AA Change: T237S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000129411 Gene: ENSMUSG00000096861 AA Change: T237S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
463 |
4.5e-28 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
1.1e-18 |
PFAM |
Pfam:7tm_3
|
589 |
827 |
3.7e-53 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
Validation Efficiency |
96% (79/82) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 81 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9930012K11Rik |
A |
T |
14: 70,393,635 (GRCm39) |
I287N |
probably benign |
Het |
Aco2 |
G |
T |
15: 81,787,820 (GRCm39) |
E223D |
probably damaging |
Het |
Acsf3 |
T |
A |
8: 123,539,770 (GRCm39) |
I466N |
probably damaging |
Het |
Albfm1 |
G |
A |
5: 90,719,625 (GRCm39) |
|
probably null |
Het |
Aox3 |
T |
A |
1: 58,191,761 (GRCm39) |
F438I |
probably benign |
Het |
Arhgap33 |
T |
C |
7: 30,225,794 (GRCm39) |
T591A |
probably benign |
Het |
Ash1l |
C |
T |
3: 88,888,694 (GRCm39) |
A191V |
probably benign |
Het |
Btg2 |
T |
C |
1: 134,006,779 (GRCm39) |
K5E |
probably benign |
Het |
C1galt1 |
T |
A |
6: 7,871,150 (GRCm39) |
Y329N |
probably damaging |
Het |
Cacna1h |
A |
G |
17: 25,608,435 (GRCm39) |
I824T |
possibly damaging |
Het |
Carmil3 |
A |
G |
14: 55,731,817 (GRCm39) |
I182V |
probably benign |
Het |
Ccdc150 |
T |
A |
1: 54,302,496 (GRCm39) |
|
probably null |
Het |
Chek1 |
T |
A |
9: 36,633,939 (GRCm39) |
R129W |
probably damaging |
Het |
Chrna6 |
A |
G |
8: 27,896,815 (GRCm39) |
M354T |
possibly damaging |
Het |
Cpq |
A |
G |
15: 33,250,185 (GRCm39) |
T181A |
probably benign |
Het |
Csmd2 |
A |
T |
4: 128,287,472 (GRCm39) |
Y1069F |
|
Het |
Defb28 |
T |
A |
2: 152,361,974 (GRCm39) |
C45S |
possibly damaging |
Het |
Dnah1 |
A |
G |
14: 31,018,551 (GRCm39) |
Y1360H |
probably benign |
Het |
Dnah7c |
T |
C |
1: 46,823,608 (GRCm39) |
V3749A |
possibly damaging |
Het |
Dnah7c |
T |
A |
1: 46,819,935 (GRCm39) |
D3728E |
probably benign |
Het |
Dym |
G |
A |
18: 75,196,245 (GRCm39) |
|
probably null |
Het |
Dync2i2 |
G |
A |
2: 29,928,341 (GRCm39) |
P95L |
probably benign |
Het |
Dzip3 |
A |
G |
16: 48,747,903 (GRCm39) |
|
probably null |
Het |
Eef1akmt4 |
A |
G |
16: 20,436,666 (GRCm39) |
K163E |
probably benign |
Het |
Fbrs |
A |
G |
7: 127,081,985 (GRCm39) |
T242A |
possibly damaging |
Het |
Fgfr3 |
G |
A |
5: 33,885,146 (GRCm39) |
V87M |
possibly damaging |
Het |
Fst |
A |
T |
13: 114,595,068 (GRCm39) |
C19S |
probably benign |
Het |
Gm7276 |
G |
A |
18: 77,273,216 (GRCm39) |
R173W |
unknown |
Het |
Gm9195 |
G |
A |
14: 72,697,929 (GRCm39) |
H1284Y |
probably benign |
Het |
Herc6 |
C |
A |
6: 57,581,074 (GRCm39) |
T258K |
probably damaging |
Het |
Hip1r |
A |
G |
5: 124,137,174 (GRCm39) |
Y678C |
probably damaging |
Het |
Ifne |
A |
T |
4: 88,798,243 (GRCm39) |
N58K |
probably damaging |
Het |
Ighv1-26 |
A |
T |
12: 114,752,163 (GRCm39) |
H60Q |
possibly damaging |
Het |
Ints1 |
A |
G |
5: 139,746,520 (GRCm39) |
F1276L |
probably damaging |
Het |
Itprid2 |
A |
T |
2: 79,466,416 (GRCm39) |
D82V |
probably damaging |
Het |
Kcnc4 |
T |
A |
3: 107,366,100 (GRCm39) |
E36V |
probably benign |
Het |
Kcnq2 |
C |
T |
2: 180,750,895 (GRCm39) |
G315S |
probably damaging |
Het |
Kdm4c |
G |
A |
4: 74,255,200 (GRCm39) |
V585M |
probably damaging |
Het |
Klhl26 |
C |
T |
8: 70,905,592 (GRCm39) |
R106H |
probably damaging |
Het |
Kmo |
T |
C |
1: 175,481,221 (GRCm39) |
F313S |
probably damaging |
Het |
Lmtk3 |
T |
A |
7: 45,443,740 (GRCm39) |
S808T |
unknown |
Het |
Lrch3 |
A |
G |
16: 32,815,363 (GRCm39) |
T585A |
probably benign |
Het |
Lrch4 |
T |
A |
5: 137,637,977 (GRCm39) |
H86Q |
|
Het |
Map3k20 |
A |
G |
2: 72,195,062 (GRCm39) |
D113G |
probably damaging |
Het |
Mbd3l1 |
T |
C |
9: 18,396,417 (GRCm39) |
S181P |
probably benign |
Het |
Mccc2 |
T |
C |
13: 100,104,241 (GRCm39) |
T303A |
probably benign |
Het |
Med27 |
A |
G |
2: 29,303,490 (GRCm39) |
R147G |
possibly damaging |
Het |
Mrps5 |
T |
A |
2: 127,437,762 (GRCm39) |
S196R |
possibly damaging |
Het |
Muc21 |
GGGGTGGGCATAGATCCTGAGGCAGAGCTGGATGCAGTGGTGGTCAGGGTGGG |
GGGGTGGG |
17: 35,932,935 (GRCm39) |
|
probably benign |
Het |
Myo16 |
A |
T |
8: 10,526,185 (GRCm39) |
|
probably null |
Het |
Nudt2 |
A |
T |
4: 41,477,575 (GRCm39) |
M19L |
probably benign |
Het |
Pcdha11 |
C |
T |
18: 37,146,245 (GRCm39) |
P779S |
probably benign |
Het |
Phykpl |
A |
G |
11: 51,489,530 (GRCm39) |
T379A |
probably benign |
Het |
Plekha8 |
A |
C |
6: 54,601,206 (GRCm39) |
M270L |
probably benign |
Het |
Plekhg5 |
A |
G |
4: 152,192,885 (GRCm39) |
H593R |
probably benign |
Het |
Polr2a |
T |
C |
11: 69,637,196 (GRCm39) |
N293S |
possibly damaging |
Het |
Pramel32 |
G |
A |
4: 88,548,184 (GRCm39) |
P74S |
probably benign |
Het |
Prex2 |
T |
A |
1: 11,232,532 (GRCm39) |
N866K |
probably benign |
Het |
Psme4 |
A |
T |
11: 30,757,790 (GRCm39) |
I308L |
probably benign |
Het |
Ptprb |
T |
C |
10: 116,177,309 (GRCm39) |
V1003A |
probably benign |
Het |
Rbbp8 |
T |
A |
18: 11,865,269 (GRCm39) |
D719E |
probably damaging |
Het |
Rnaset2b |
A |
T |
17: 7,259,166 (GRCm39) |
D144V |
probably benign |
Het |
Senp6 |
T |
G |
9: 80,033,481 (GRCm39) |
D662E |
probably damaging |
Het |
Serpinb3c |
T |
C |
1: 107,200,817 (GRCm39) |
N200S |
possibly damaging |
Het |
Serpinb9g |
C |
G |
13: 33,672,543 (GRCm39) |
Y113* |
probably null |
Het |
Sgf29 |
T |
C |
7: 126,270,821 (GRCm39) |
I134T |
probably benign |
Het |
Sh3bp4 |
T |
G |
1: 89,080,824 (GRCm39) |
|
probably null |
Het |
Stab1 |
G |
A |
14: 30,862,783 (GRCm39) |
L2243F |
probably damaging |
Het |
Sympk |
T |
C |
7: 18,769,770 (GRCm39) |
V149A |
probably benign |
Het |
Syt3 |
C |
T |
7: 44,041,953 (GRCm39) |
Q271* |
probably null |
Het |
Tas2r109 |
A |
G |
6: 132,957,663 (GRCm39) |
I89T |
probably benign |
Het |
Tgif1 |
A |
G |
17: 71,151,847 (GRCm39) |
S255P |
probably damaging |
Het |
Tm9sf1 |
G |
A |
14: 55,875,432 (GRCm39) |
|
probably benign |
Het |
Tnf |
A |
G |
17: 35,419,347 (GRCm39) |
F161S |
possibly damaging |
Het |
Topaz1 |
T |
A |
9: 122,579,428 (GRCm39) |
S779R |
possibly damaging |
Het |
Topors |
A |
G |
4: 40,260,540 (GRCm39) |
S915P |
unknown |
Het |
Tpm4 |
C |
T |
8: 72,900,321 (GRCm39) |
L161F |
probably damaging |
Het |
Trim38 |
C |
T |
13: 23,975,384 (GRCm39) |
T441I |
probably damaging |
Het |
Trpv1 |
A |
G |
11: 73,141,620 (GRCm39) |
M548V |
probably benign |
Het |
Zc3hav1 |
A |
G |
6: 38,309,209 (GRCm39) |
S538P |
probably benign |
Het |
Zfp541 |
C |
T |
7: 15,813,294 (GRCm39) |
T649I |
probably benign |
Het |
|
Other mutations in Vmn2r68 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01391:Vmn2r68
|
APN |
7 |
84,886,819 (GRCm39) |
missense |
probably benign |
|
IGL01477:Vmn2r68
|
APN |
7 |
84,882,691 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01600:Vmn2r68
|
APN |
7 |
84,871,468 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01979:Vmn2r68
|
APN |
7 |
84,871,325 (GRCm39) |
missense |
probably benign |
|
IGL01999:Vmn2r68
|
APN |
7 |
84,871,439 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02269:Vmn2r68
|
APN |
7 |
84,870,947 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02517:Vmn2r68
|
APN |
7 |
84,871,153 (GRCm39) |
nonsense |
probably null |
|
IGL02827:Vmn2r68
|
APN |
7 |
84,886,800 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02852:Vmn2r68
|
APN |
7 |
84,882,595 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02982:Vmn2r68
|
APN |
7 |
84,883,649 (GRCm39) |
missense |
probably benign |
0.12 |
IGL03099:Vmn2r68
|
APN |
7 |
84,871,448 (GRCm39) |
nonsense |
probably null |
|
IGL03166:Vmn2r68
|
APN |
7 |
84,871,331 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03168:Vmn2r68
|
APN |
7 |
84,870,972 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03243:Vmn2r68
|
APN |
7 |
84,882,963 (GRCm39) |
missense |
possibly damaging |
0.66 |
F5770:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
R0280:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0280:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0348:Vmn2r68
|
UTSW |
7 |
84,870,884 (GRCm39) |
missense |
possibly damaging |
0.50 |
R0390:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0390:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0722:Vmn2r68
|
UTSW |
7 |
84,870,794 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1129:Vmn2r68
|
UTSW |
7 |
84,886,712 (GRCm39) |
splice site |
probably null |
|
R1136:Vmn2r68
|
UTSW |
7 |
84,871,549 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1319:Vmn2r68
|
UTSW |
7 |
84,881,700 (GRCm39) |
missense |
probably damaging |
0.96 |
R1614:Vmn2r68
|
UTSW |
7 |
84,870,946 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1682:Vmn2r68
|
UTSW |
7 |
84,882,574 (GRCm39) |
missense |
possibly damaging |
0.68 |
R1837:Vmn2r68
|
UTSW |
7 |
84,882,886 (GRCm39) |
missense |
probably damaging |
0.96 |
R1893:Vmn2r68
|
UTSW |
7 |
84,883,867 (GRCm39) |
nonsense |
probably null |
|
R1908:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
R1909:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
R1951:Vmn2r68
|
UTSW |
7 |
84,883,102 (GRCm39) |
missense |
probably damaging |
1.00 |
R2177:Vmn2r68
|
UTSW |
7 |
84,871,123 (GRCm39) |
missense |
probably benign |
0.01 |
R2178:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R2185:Vmn2r68
|
UTSW |
7 |
84,882,901 (GRCm39) |
nonsense |
probably null |
|
R2188:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R2282:Vmn2r68
|
UTSW |
7 |
84,870,859 (GRCm39) |
missense |
possibly damaging |
0.65 |
R2567:Vmn2r68
|
UTSW |
7 |
84,883,803 (GRCm39) |
missense |
probably benign |
|
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2873:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2874:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R3149:Vmn2r68
|
UTSW |
7 |
84,886,875 (GRCm39) |
missense |
probably benign |
0.00 |
R3401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R3978:Vmn2r68
|
UTSW |
7 |
84,881,670 (GRCm39) |
missense |
probably benign |
0.00 |
R4399:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4421:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4478:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4479:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4495:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4628:Vmn2r68
|
UTSW |
7 |
84,883,673 (GRCm39) |
missense |
probably benign |
0.00 |
R4649:Vmn2r68
|
UTSW |
7 |
84,870,743 (GRCm39) |
missense |
probably benign |
|
R4654:Vmn2r68
|
UTSW |
7 |
84,882,769 (GRCm39) |
nonsense |
probably null |
|
R4793:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
R5007:Vmn2r68
|
UTSW |
7 |
84,881,622 (GRCm39) |
missense |
probably benign |
|
R5021:Vmn2r68
|
UTSW |
7 |
84,882,942 (GRCm39) |
missense |
possibly damaging |
0.62 |
R5082:Vmn2r68
|
UTSW |
7 |
84,883,076 (GRCm39) |
missense |
probably benign |
0.12 |
R5177:Vmn2r68
|
UTSW |
7 |
84,871,199 (GRCm39) |
missense |
probably damaging |
0.99 |
R5221:Vmn2r68
|
UTSW |
7 |
84,871,085 (GRCm39) |
missense |
probably damaging |
1.00 |
R5514:Vmn2r68
|
UTSW |
7 |
84,886,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5521:Vmn2r68
|
UTSW |
7 |
84,882,926 (GRCm39) |
missense |
probably benign |
0.03 |
R5563:Vmn2r68
|
UTSW |
7 |
84,871,283 (GRCm39) |
missense |
probably damaging |
1.00 |
R5664:Vmn2r68
|
UTSW |
7 |
84,882,978 (GRCm39) |
missense |
probably benign |
0.02 |
R5829:Vmn2r68
|
UTSW |
7 |
84,886,812 (GRCm39) |
missense |
probably benign |
0.00 |
R6016:Vmn2r68
|
UTSW |
7 |
84,871,453 (GRCm39) |
missense |
probably damaging |
0.99 |
R6356:Vmn2r68
|
UTSW |
7 |
84,883,048 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6413:Vmn2r68
|
UTSW |
7 |
84,870,973 (GRCm39) |
missense |
probably damaging |
1.00 |
R6418:Vmn2r68
|
UTSW |
7 |
84,882,915 (GRCm39) |
missense |
probably benign |
|
R6699:Vmn2r68
|
UTSW |
7 |
84,881,583 (GRCm39) |
missense |
possibly damaging |
0.58 |
R7287:Vmn2r68
|
UTSW |
7 |
84,871,460 (GRCm39) |
missense |
probably benign |
0.33 |
R7374:Vmn2r68
|
UTSW |
7 |
84,881,607 (GRCm39) |
missense |
possibly damaging |
0.66 |
R7585:Vmn2r68
|
UTSW |
7 |
84,881,587 (GRCm39) |
missense |
probably damaging |
1.00 |
R7605:Vmn2r68
|
UTSW |
7 |
84,883,116 (GRCm39) |
missense |
probably benign |
0.01 |
R7892:Vmn2r68
|
UTSW |
7 |
84,883,722 (GRCm39) |
missense |
probably benign |
|
R7979:Vmn2r68
|
UTSW |
7 |
84,883,625 (GRCm39) |
critical splice donor site |
probably null |
|
R8177:Vmn2r68
|
UTSW |
7 |
84,871,422 (GRCm39) |
nonsense |
probably null |
|
R8349:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R8378:Vmn2r68
|
UTSW |
7 |
84,871,108 (GRCm39) |
missense |
probably benign |
0.00 |
R8397:Vmn2r68
|
UTSW |
7 |
84,886,722 (GRCm39) |
missense |
possibly damaging |
0.71 |
R8449:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R8543:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
R8680:Vmn2r68
|
UTSW |
7 |
84,871,321 (GRCm39) |
missense |
possibly damaging |
0.68 |
R9056:Vmn2r68
|
UTSW |
7 |
84,871,420 (GRCm39) |
missense |
possibly damaging |
0.71 |
R9342:Vmn2r68
|
UTSW |
7 |
84,882,993 (GRCm39) |
missense |
probably benign |
0.39 |
R9734:Vmn2r68
|
UTSW |
7 |
84,882,757 (GRCm39) |
missense |
possibly damaging |
0.54 |
V7581:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,289 (GRCm39) |
missense |
probably benign |
0.27 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,870,941 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,307 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTCCCAGAGGAGGAATATAGC -3'
(R):5'- CTTTACCAGATATCTCCCAAGGAC -3'
Sequencing Primer
(F):5'- GCATGAAATCTCCTAGATATGTGATC -3'
(R):5'- GGACACATCTCTACCACTAGCGATG -3'
|
Posted On |
2019-06-26 |