Incidental Mutation 'IGL01386:Zfp667'
| ID |
79059 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp667
|
| Ensembl Gene |
ENSMUSG00000054893 |
| Gene Name |
zinc finger protein 667 |
| Synonyms |
A830025F02Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL01386
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
6289578-6310882 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 6307869 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Arginine
at position 179
(H179R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128658
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086327]
[ENSMUST00000108562]
[ENSMUST00000153840]
[ENSMUST00000170776]
|
| AlphaFold |
Q2TL60 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086327
AA Change: H179R
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000083507
Gene: ENSMUSG00000054893
AA Change: H179R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108562
AA Change: H179R
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000104202
Gene: ENSMUSG00000054893
AA Change: H179R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153840
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170776
AA Change: H179R
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000128658
Gene: ENSMUSG00000054893
AA Change: H179R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(4) : Targeted, other(2) Gene trapped(2)
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actn1 |
T |
C |
12: 80,240,446 (GRCm39) |
R214G |
probably benign |
Het |
| Cacna1e |
T |
A |
1: 154,348,123 (GRCm39) |
K817N |
probably benign |
Het |
| Cyp3a16 |
A |
G |
5: 145,377,244 (GRCm39) |
F448L |
probably damaging |
Het |
| Dpp6 |
T |
A |
5: 27,869,760 (GRCm39) |
|
probably null |
Het |
| Eif2ak3 |
C |
T |
6: 70,869,710 (GRCm39) |
T799M |
probably damaging |
Het |
| Erbb4 |
A |
T |
1: 68,383,090 (GRCm39) |
S302R |
probably damaging |
Het |
| Fam217a |
T |
A |
13: 35,099,632 (GRCm39) |
|
probably benign |
Het |
| Flt4 |
C |
A |
11: 49,528,162 (GRCm39) |
A995D |
probably benign |
Het |
| Fpr-rs7 |
G |
A |
17: 20,334,454 (GRCm39) |
S12L |
probably damaging |
Het |
| Fsd1 |
C |
T |
17: 56,303,733 (GRCm39) |
S491F |
probably damaging |
Het |
| Hpcal4 |
T |
C |
4: 123,083,035 (GRCm39) |
|
probably null |
Het |
| Intu |
A |
T |
3: 40,647,017 (GRCm39) |
D630V |
probably damaging |
Het |
| Jak3 |
A |
G |
8: 72,136,933 (GRCm39) |
D703G |
probably damaging |
Het |
| Lama4 |
A |
G |
10: 38,887,060 (GRCm39) |
I122V |
probably benign |
Het |
| Mrpl11 |
A |
C |
19: 5,013,409 (GRCm39) |
K92T |
probably null |
Het |
| Mtarc2 |
A |
G |
1: 184,551,413 (GRCm39) |
|
probably benign |
Het |
| Mylk |
A |
G |
16: 34,791,610 (GRCm39) |
|
probably null |
Het |
| Or52ab4 |
A |
T |
7: 102,987,974 (GRCm39) |
K238* |
probably null |
Het |
| Parpbp |
A |
C |
10: 87,975,848 (GRCm39) |
Y88* |
probably null |
Het |
| Plod2 |
G |
A |
9: 92,488,655 (GRCm39) |
R627Q |
probably damaging |
Het |
| Rapsn |
G |
T |
2: 90,867,144 (GRCm39) |
A149S |
probably damaging |
Het |
| Ripk3 |
T |
G |
14: 56,023,484 (GRCm39) |
Q109P |
probably damaging |
Het |
| Scaf11 |
T |
C |
15: 96,318,361 (GRCm39) |
D401G |
probably damaging |
Het |
| Serpine2 |
G |
A |
1: 79,779,268 (GRCm39) |
T150I |
probably damaging |
Het |
| Sh2d6 |
T |
A |
6: 72,495,945 (GRCm39) |
T98S |
probably benign |
Het |
| Slc28a1 |
G |
T |
7: 80,814,427 (GRCm39) |
A513S |
probably benign |
Het |
| Tanc2 |
T |
C |
11: 105,777,207 (GRCm39) |
F795S |
probably damaging |
Het |
| Tcim |
T |
A |
8: 24,928,705 (GRCm39) |
I70F |
probably benign |
Het |
| Thbd |
G |
A |
2: 148,249,602 (GRCm39) |
Q89* |
probably null |
Het |
| Tmem115 |
C |
T |
9: 107,411,859 (GRCm39) |
T61I |
probably damaging |
Het |
| Tsc2 |
A |
T |
17: 24,832,259 (GRCm39) |
V650E |
probably damaging |
Het |
| Tubgcp6 |
A |
T |
15: 88,992,199 (GRCm39) |
Y595* |
probably null |
Het |
| Uroc1 |
C |
T |
6: 90,323,747 (GRCm39) |
A398V |
probably damaging |
Het |
| Vmn1r31 |
T |
C |
6: 58,449,587 (GRCm39) |
T93A |
probably benign |
Het |
| Vmn2r113 |
A |
G |
17: 23,175,024 (GRCm39) |
E545G |
possibly damaging |
Het |
| Vps13a |
A |
G |
19: 16,678,516 (GRCm39) |
V1155A |
possibly damaging |
Het |
|
| Other mutations in Zfp667 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00821:Zfp667
|
APN |
7 |
6,308,396 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL01325:Zfp667
|
APN |
7 |
6,293,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01960:Zfp667
|
APN |
7 |
6,308,336 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03394:Zfp667
|
APN |
7 |
6,292,438 (GRCm39) |
critical splice donor site |
probably null |
|
|
B5639:Zfp667
|
UTSW |
7 |
6,293,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0458:Zfp667
|
UTSW |
7 |
6,307,844 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0845:Zfp667
|
UTSW |
7 |
6,309,091 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1768:Zfp667
|
UTSW |
7 |
6,308,066 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1953:Zfp667
|
UTSW |
7 |
6,308,087 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2023:Zfp667
|
UTSW |
7 |
6,308,416 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3159:Zfp667
|
UTSW |
7 |
6,308,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Zfp667
|
UTSW |
7 |
6,308,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4476:Zfp667
|
UTSW |
7 |
6,307,598 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4584:Zfp667
|
UTSW |
7 |
6,293,624 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4783:Zfp667
|
UTSW |
7 |
6,308,684 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5037:Zfp667
|
UTSW |
7 |
6,308,949 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5300:Zfp667
|
UTSW |
7 |
6,307,635 (GRCm39) |
missense |
probably benign |
|
|
R5311:Zfp667
|
UTSW |
7 |
6,308,715 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5312:Zfp667
|
UTSW |
7 |
6,308,466 (GRCm39) |
missense |
probably benign |
|
|
R5340:Zfp667
|
UTSW |
7 |
6,308,252 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6262:Zfp667
|
UTSW |
7 |
6,307,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7386:Zfp667
|
UTSW |
7 |
6,308,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8383:Zfp667
|
UTSW |
7 |
6,308,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8919:Zfp667
|
UTSW |
7 |
6,308,256 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9099:Zfp667
|
UTSW |
7 |
6,308,322 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9422:Zfp667
|
UTSW |
7 |
6,308,321 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfp667
|
UTSW |
7 |
6,307,856 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Posted On |
2013-11-05 |
Incidental Mutation