Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00091:Dnajc22'

889

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dnajc22

Ensembl Gene

ENSMUSG00000038009

Gene Name

DnaJ heat shock protein family (Hsp40) member C22

Synonyms

2810451A06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL00091

Quality Score

Status

Chromosome

Chromosomal Location

98991102-99002618 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 98999059 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 81 (F81L)

Ref Sequence

ENSEMBL: ENSMUSP00000055482 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061295]

AlphaFold

Q8CHS2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000061295
AA Change: F81L

PolyPhen 2 Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000055482
Gene: ENSMUSG00000038009
AA Change: F81L

Domain	Start	End	E-Value	Type
Pfam:TM2	1	50	1e-10	PFAM
transmembrane domain	76	98	N/A	INTRINSIC
transmembrane domain	105	124	N/A	INTRINSIC
transmembrane domain	139	161	N/A	INTRINSIC
transmembrane domain	206	228	N/A	INTRINSIC
DnaJ	276	335	1.09e-19	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146173

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abraxas2	A	T	7: 132,485,157 (GRCm39)	Y400F	probably benign	Het
Adamts8	C	A	9: 30,864,796 (GRCm39)	T429K	probably damaging	Het
Adgrv1	C	T	13: 81,726,220 (GRCm39)	D602N	probably damaging	Het
Ano7	A	T	1: 93,329,888 (GRCm39)	H775L	probably benign	Het
Apoo-ps	A	T	13: 107,551,134 (GRCm39)		noncoding transcript	Het
Arid2	T	C	15: 96,270,183 (GRCm39)	V1432A	probably benign	Het
Atoh1	T	C	6: 64,706,568 (GRCm39)	S88P	possibly damaging	Het
C130050O18Rik	A	G	5: 139,400,601 (GRCm39)	E218G	probably damaging	Het
Cacna2d1	T	A	5: 16,417,942 (GRCm39)	F155L	probably damaging	Het
Car4	C	T	11: 84,856,593 (GRCm39)	P294S	probably damaging	Het
Cyp1a2	G	T	9: 57,589,352 (GRCm39)	S154*	probably null	Het
Cyp3a25	A	T	5: 145,938,273 (GRCm39)	Y68*	probably null	Het
Dmbt1	C	A	7: 130,681,270 (GRCm39)		probably benign	Het
Eml5	G	A	12: 98,839,468 (GRCm39)		probably benign	Het
Fpgs	A	T	2: 32,576,559 (GRCm39)		probably benign	Het
Gab2	T	C	7: 96,951,650 (GRCm39)	S537P	possibly damaging	Het
Gmds	G	A	13: 32,418,373 (GRCm39)	S37L	probably damaging	Het
Ipo13	T	C	4: 117,760,602 (GRCm39)	E626G	probably benign	Het
Kcng1	T	C	2: 168,110,684 (GRCm39)	H160R	probably benign	Het
Lama3	A	G	18: 12,713,349 (GRCm39)	T1608A	probably benign	Het
Lama4	A	C	10: 38,948,801 (GRCm39)	S855R	probably damaging	Het
Ltbp1	C	T	17: 75,532,333 (GRCm39)	H454Y	probably damaging	Het
Map3k14	C	A	11: 103,118,405 (GRCm39)	G594C	probably damaging	Het
Mcph1	A	G	8: 18,682,636 (GRCm39)	N591S	possibly damaging	Het
Moxd1	G	A	10: 24,155,762 (GRCm39)	V289I	probably damaging	Het
Mptx2	T	G	1: 173,102,455 (GRCm39)	N78T	probably damaging	Het
Muc4	G	A	16: 32,754,086 (GRCm38)	G1321R	probably benign	Het
Muc6	A	C	7: 141,218,497 (GRCm39)	S2059A	probably benign	Het
Nup50	T	A	15: 84,819,605 (GRCm39)	F293Y	probably benign	Het
Ogn	A	G	13: 49,774,514 (GRCm39)	Y219C	probably damaging	Het
Pdia3	T	C	2: 121,244,659 (GRCm39)	L47P	probably damaging	Het
Piwil4	A	T	9: 14,614,393 (GRCm39)	D786E	probably damaging	Het
Pspc1	A	G	14: 57,009,168 (GRCm39)	L222P	probably damaging	Het
Ptchd3	T	A	11: 121,721,972 (GRCm39)	Y282N	probably damaging	Het
Reln	C	A	5: 22,244,563 (GRCm39)	G805V	possibly damaging	Het
Serpini2	T	C	3: 75,156,549 (GRCm39)	Y327C	probably damaging	Het
Spire2	A	G	8: 124,080,798 (GRCm39)	D14G	probably damaging	Het
Stab2	A	T	10: 86,705,070 (GRCm39)		probably null	Het
Timeless	T	C	10: 128,077,577 (GRCm39)	L219P	probably damaging	Het
Tmem63a	C	T	1: 180,790,653 (GRCm39)	T437M	probably damaging	Het
Tslp	A	G	18: 32,948,448 (GRCm39)		probably benign	Het
Ttbk2	C	A	2: 120,579,314 (GRCm39)	G534*	probably null	Het
Uggt1	T	C	1: 36,218,633 (GRCm39)		probably benign	Het
Vmn2r118	T	C	17: 55,899,708 (GRCm39)	E732G	probably damaging	Het
Zfhx2	G	A	14: 55,304,022 (GRCm39)	P1321S	possibly damaging	Het
Zfp58	A	G	13: 67,639,114 (GRCm39)	V459A	probably benign	Het
Zfp831	T	C	2: 174,487,451 (GRCm39)	S709P	possibly damaging	Het

Other mutations in Dnajc22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Dnajc22	APN	15	98,999,460 (GRCm39)	missense	possibly damaging	0.89
IGL02155:Dnajc22	APN	15	98,998,886 (GRCm39)	missense	probably damaging	1.00
IGL02726:Dnajc22	APN	15	98,998,881 (GRCm39)	missense	probably damaging	1.00
IGL03074:Dnajc22	APN	15	98,999,403 (GRCm39)	missense	probably damaging	1.00
F5770:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
R1138:Dnajc22	UTSW	15	99,002,308 (GRCm39)	small deletion	probably benign
R1628:Dnajc22	UTSW	15	98,998,817 (GRCm39)	start codon destroyed	probably null	1.00
R2018:Dnajc22	UTSW	15	98,999,114 (GRCm39)	missense	probably benign	0.06
R2146:Dnajc22	UTSW	15	99,002,264 (GRCm39)	missense	probably benign	0.04
R4342:Dnajc22	UTSW	15	99,002,345 (GRCm39)	nonsense	probably null
R4950:Dnajc22	UTSW	15	98,999,615 (GRCm39)	missense	probably benign	0.29
R7123:Dnajc22	UTSW	15	98,999,085 (GRCm39)	missense	possibly damaging	0.89
R7173:Dnajc22	UTSW	15	98,999,187 (GRCm39)	missense	probably benign	0.06
R7640:Dnajc22	UTSW	15	98,998,995 (GRCm39)	missense	probably damaging	1.00
R7997:Dnajc22	UTSW	15	98,999,514 (GRCm39)	missense	probably damaging	1.00
R8338:Dnajc22	UTSW	15	98,999,022 (GRCm39)	missense	probably benign	0.00
R8745:Dnajc22	UTSW	15	98,999,345 (GRCm39)	missense	probably benign	0.01
V7580:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7581:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7582:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99
V7583:Dnajc22	UTSW	15	98,999,363 (GRCm39)	missense	probably damaging	0.99

Posted On

2011-07-12