Incidental Mutation 'IGL01744:Gm10696'
ID152971
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10696
Ensembl Gene ENSMUSG00000074424
Gene Namepredicted gene 10696
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.926) question?
Stock #IGL01744
Quality Score
Status
Chromosome3
Chromosomal Location94174412-94178193 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 94176237 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Methionine at position 89 (K89M)
Ref Sequence ENSEMBL: ENSMUSP00000132199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161475] [ENSMUST00000167916]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159115
Predicted Effect probably damaging
Transcript: ENSMUST00000161475
AA Change: K89M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124942
Gene: ENSMUSG00000074424
AA Change: K89M

DomainStartEndE-ValueType
MATH 24 130 4.7e-10 SMART
BTB 188 287 1.53e-25 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000167916
AA Change: K89M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132199
Gene: ENSMUSG00000074424
AA Change: K89M

DomainStartEndE-ValueType
MATH 24 130 4.7e-10 SMART
BTB 188 287 1.53e-25 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik T C 7: 12,550,532 I102T possibly damaging Het
4933412E24Rik C A 15: 60,015,575 A339S possibly damaging Het
Ackr2 A G 9: 121,909,119 T187A probably benign Het
Adam28 A G 14: 68,607,507 V777A probably benign Het
Add3 T A 19: 53,239,430 D515E probably damaging Het
Aire C A 10: 78,036,723 E354* probably null Het
AW551984 T C 9: 39,591,272 K670R probably benign Het
Bahcc1 T C 11: 120,271,737 V287A probably benign Het
Brca1 T C 11: 101,524,176 N1044S possibly damaging Het
Bub1b T A 2: 118,636,749 I851N probably damaging Het
Ceacam11 A T 7: 17,973,398 I36F possibly damaging Het
Copa A G 1: 172,113,189 E714G probably benign Het
Cth A T 3: 157,924,935 N32K probably benign Het
Cyp2a5 T A 7: 26,841,009 M349K probably damaging Het
D130052B06Rik A G 11: 33,623,966 S188G unknown Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Flt1 T C 5: 147,571,461 N1161S probably benign Het
Hip1 T C 5: 135,545,063 probably benign Het
Mapk11 A G 15: 89,146,843 probably benign Het
Mtif2 A G 11: 29,544,417 probably benign Het
Myo1f C A 17: 33,583,680 probably benign Het
Nipsnap1 G A 11: 4,889,912 R211H probably damaging Het
Olfr599 A G 7: 103,338,228 H58R probably damaging Het
Olfr781 T C 10: 129,333,457 I192T probably benign Het
Pcdh1 A T 18: 38,203,249 I111N probably damaging Het
Piezo2 T A 18: 63,042,788 I1841F probably damaging Het
Pirb G T 7: 3,717,176 Y399* probably null Het
Ppp1r36 A T 12: 76,439,232 N388I possibly damaging Het
Prr16 A G 18: 51,302,989 D180G possibly damaging Het
Prss39 A G 1: 34,502,199 probably null Het
Trank1 T A 9: 111,349,363 V373D probably damaging Het
Ubn1 A G 16: 5,072,059 E186G probably damaging Het
Zmym2 T C 14: 56,946,572 V997A probably benign Het
Other mutations in Gm10696
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02057:Gm10696 APN 3 94176355 missense probably damaging 1.00
R1983:Gm10696 UTSW 3 94176294 missense possibly damaging 0.89
R2102:Gm10696 UTSW 3 94175666 nonsense probably null
R2110:Gm10696 UTSW 3 94175527 missense probably damaging 0.99
R2172:Gm10696 UTSW 3 94176298 missense possibly damaging 0.68
R2358:Gm10696 UTSW 3 94175547 missense possibly damaging 0.81
R2358:Gm10696 UTSW 3 94175548 missense possibly damaging 0.61
R4534:Gm10696 UTSW 3 94176450 missense probably benign 0.39
R4939:Gm10696 UTSW 3 94176233 nonsense probably null
R4961:Gm10696 UTSW 3 94175534 nonsense probably null
R4993:Gm10696 UTSW 3 94176316 missense probably damaging 1.00
R7154:Gm10696 UTSW 3 94176219 missense probably benign 0.17
R7218:Gm10696 UTSW 3 94175549 missense possibly damaging 0.91
R7256:Gm10696 UTSW 3 94176360 missense probably benign 0.01
R7464:Gm10696 UTSW 3 94176104 missense probably benign 0.08
R7473:Gm10696 UTSW 3 94176202 nonsense probably null
R7596:Gm10696 UTSW 3 94176430 missense probably benign 0.12
Z1177:Gm10696 UTSW 3 94176102 missense probably benign 0.03
Posted On2014-02-04