Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01814:Tmem101'

154357

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem101

Ensembl Gene

ENSMUSG00000020921

Gene Name

transmembrane protein 101

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL01814

Quality Score

Status

Chromosome

Chromosomal Location

102152546-102156404 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 102153458 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 201 (T201M)

Ref Sequence

ENSEMBL: ENSMUSP00000021296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021296] [ENSMUST00000055409]

AlphaFold

Q91VP7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000021296
AA Change: T201M

PolyPhen 2 Score 0.582 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000021296
Gene: ENSMUSG00000020921
AA Change: T201M

Domain	Start	End	E-Value	Type
Pfam:TMEM101	8	256	9.9e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000055409

SMART Domains

Protein: ENSMUSP00000050258
Gene: ENSMUSG00000048217

Domain	Start	End	E-Value	Type
low complexity region	9	48	N/A	INTRINSIC
low complexity region	77	90	N/A	INTRINSIC
Pfam:NAT	349	514	3.5e-50	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136434

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143986

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147252

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	T	A	18: 67,405,474	N738I	probably benign	Het
B3galnt2	A	G	13: 13,987,353	S1G	probably damaging	Het
Btbd9	T	C	17: 30,299,535	I484V	probably benign	Het
Chd6	T	C	2: 161,059,929	K8R	probably benign	Het
Csmd1	A	C	8: 16,501,375	L279R	probably damaging	Het
Dmxl1	G	T	18: 49,864,868	V708F	probably damaging	Het
Dnajc24	C	T	2: 105,981,084	G49R	probably benign	Het
Dnhd1	T	C	7: 105,652,030	M198T	probably benign	Het
Dtx3l	T	A	16: 35,931,502	D683V	probably benign	Het
Duox1	A	G	2: 122,346,272	T1425A	probably damaging	Het
Enpp3	G	A	10: 24,792,025	P510S	possibly damaging	Het
Iars2	G	T	1: 185,302,775	Y590*	probably null	Het
Itgb7	T	C	15: 102,223,417	R244G	possibly damaging	Het
Itpr2	T	A	6: 146,232,546	R1820S	probably benign	Het
Matn3	T	C	12: 8,952,091	V101A	probably damaging	Het
Neurod1	C	T	2: 79,454,659	V127M	probably damaging	Het
Olfr1505	T	A	19: 13,919,528	C169*	probably null	Het
Olfr683	T	C	7: 105,143,604	I236V	possibly damaging	Het
Pde10a	A	G	17: 8,929,107	M1V	probably null	Het
Pdk4	A	G	6: 5,491,828		probably null	Het
Ptchd4	A	T	17: 42,503,286	I693F	possibly damaging	Het
Scml4	C	T	10: 42,935,045	R194C	probably damaging	Het
Slc24a4	T	C	12: 102,254,618	V436A	probably benign	Het
Slc9a3	C	A	13: 74,165,972	R800S	probably damaging	Het
Smchd1	C	A	17: 71,378,187	M1415I	probably benign	Het
Syndig1	T	A	2: 149,899,770	I92N	probably damaging	Het
Tchhl1	T	C	3: 93,470,349	V120A	possibly damaging	Het
Thumpd3	C	T	6: 113,063,151	T332I	possibly damaging	Het
Trip11	T	C	12: 101,884,488	T1106A	probably damaging	Het
Ttc41	C	T	10: 86,731,026	R519C	probably damaging	Het
Xirp1	T	A	9: 120,017,919	M633L	probably damaging	Het
Zfp938	A	T	10: 82,226,218	D189E	probably benign	Het

Other mutations in Tmem101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Tmem101	APN	11	102154660	missense	probably damaging	0.99
IGL01096:Tmem101	APN	11	102154552	splice site	probably null
IGL01593:Tmem101	APN	11	102155878	missense	probably damaging	1.00
IGL02451:Tmem101	APN	11	102153293	missense	probably damaging	1.00
IGL03238:Tmem101	APN	11	102155785	missense	probably damaging	1.00
R0462:Tmem101	UTSW	11	102155867	missense	probably benign	0.08
R0848:Tmem101	UTSW	11	102155866	missense	possibly damaging	0.65
R1465:Tmem101	UTSW	11	102153329	missense	probably damaging	0.97
R1465:Tmem101	UTSW	11	102153329	missense	probably damaging	0.97
R1722:Tmem101	UTSW	11	102154693	missense	probably damaging	1.00
R1928:Tmem101	UTSW	11	102153396	missense	probably benign
R2082:Tmem101	UTSW	11	102153377	missense	probably benign	0.17
R4577:Tmem101	UTSW	11	102155837	missense	possibly damaging	0.48
R4724:Tmem101	UTSW	11	102153443	missense	probably benign	0.32
R4729:Tmem101	UTSW	11	102156329	missense	probably benign	0.25
R5146:Tmem101	UTSW	11	102154624	missense	probably benign
R5184:Tmem101	UTSW	11	102156233	missense	possibly damaging	0.78
R7381:Tmem101	UTSW	11	102153350	missense	possibly damaging	0.91
R8799:Tmem101	UTSW	11	102153510	missense	probably benign	0.08
R9612:Tmem101	UTSW	11	102153368	missense	probably damaging	1.00

Posted On

2014-02-04