Incidental Mutation 'IGL02011:Or9s15'
| ID |
183355 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or9s15
|
| Ensembl Gene |
ENSMUSG00000062497 |
| Gene Name |
olfactory receptor family 9 subfamily S member 15 |
| Synonyms |
Olfr1411, MOR208-3, GA_x6K02T2R7CC-81157497-81156526 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL02011
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
92524243-92525214 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 92524621 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 127
(Y127N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150254
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073748]
[ENSMUST00000190844]
[ENSMUST00000216444]
|
| AlphaFold |
Q8VFC4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073748
AA Change: Y127N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: Y127N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
Pfam:7tm_4
|
38 |
314 |
7.4e-53 |
PFAM |
|
Pfam:7tm_1
|
48 |
297 |
1.2e-17 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000190844
AA Change: Y127N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140373
Gene: ENSMUSG00000062497
AA Change: Y127N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
32 |
44 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
48 |
297 |
6.7e-25 |
PFAM |
|
Pfam:7tm_4
|
146 |
290 |
2.9e-45 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203299
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000216444
AA Change: Y127N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ap5m1 |
T |
A |
14: 49,318,592 (GRCm39) |
|
probably benign |
Het |
| Arg1 |
T |
C |
10: 24,792,275 (GRCm39) |
T215A |
probably benign |
Het |
| Arhgap15 |
A |
T |
2: 43,670,767 (GRCm39) |
K50N |
probably damaging |
Het |
| Ctdsp1 |
C |
T |
1: 74,433,175 (GRCm39) |
|
probably benign |
Het |
| Cwc22 |
A |
T |
2: 77,751,366 (GRCm39) |
D363E |
possibly damaging |
Het |
| Drd2 |
G |
T |
9: 49,318,258 (GRCm39) |
C400F |
probably damaging |
Het |
| Eef1akmt1 |
A |
T |
14: 57,795,555 (GRCm39) |
Y65N |
probably damaging |
Het |
| Gbp10 |
C |
A |
5: 105,368,967 (GRCm39) |
G291W |
probably damaging |
Het |
| Lrit1 |
T |
A |
14: 36,784,280 (GRCm39) |
V536E |
probably damaging |
Het |
| Or4d1 |
C |
A |
11: 87,805,708 (GRCm39) |
W8L |
probably benign |
Het |
| Or52ab4 |
G |
T |
7: 102,988,056 (GRCm39) |
R265L |
probably damaging |
Het |
| Pcdh12 |
C |
T |
18: 38,414,473 (GRCm39) |
G884D |
probably damaging |
Het |
| Pih1d1 |
G |
T |
7: 44,806,156 (GRCm39) |
A31S |
probably damaging |
Het |
| Plcxd2 |
T |
C |
16: 45,785,454 (GRCm39) |
D317G |
probably damaging |
Het |
| Prkaca |
T |
C |
8: 84,717,565 (GRCm39) |
F231S |
probably damaging |
Het |
| Raet1d |
T |
A |
10: 22,247,473 (GRCm39) |
I183K |
probably damaging |
Het |
| Scaper |
A |
G |
9: 55,487,606 (GRCm39) |
F752S |
probably damaging |
Het |
| Shisa9 |
C |
T |
16: 12,062,502 (GRCm39) |
T241I |
possibly damaging |
Het |
| Taar9 |
C |
T |
10: 23,984,477 (GRCm39) |
R319H |
possibly damaging |
Het |
| Unkl |
T |
A |
17: 25,437,565 (GRCm39) |
V365E |
probably damaging |
Het |
| Usp34 |
C |
T |
11: 23,421,554 (GRCm39) |
S3077F |
probably damaging |
Het |
| Vps16 |
A |
G |
2: 130,283,399 (GRCm39) |
I566V |
probably benign |
Het |
| Vrk2 |
T |
A |
11: 26,421,717 (GRCm39) |
T414S |
probably benign |
Het |
| Xpnpep1 |
A |
T |
19: 52,990,896 (GRCm39) |
|
probably benign |
Het |
| Zfp804a |
A |
G |
2: 82,087,035 (GRCm39) |
Q288R |
probably damaging |
Het |
|
| Other mutations in Or9s15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Or9s15
|
APN |
1 |
92,524,922 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
PIT4810001:Or9s15
|
UTSW |
1 |
92,524,876 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2036:Or9s15
|
UTSW |
1 |
92,524,328 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2044:Or9s15
|
UTSW |
1 |
92,524,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4133:Or9s15
|
UTSW |
1 |
92,524,465 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4406:Or9s15
|
UTSW |
1 |
92,525,036 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4568:Or9s15
|
UTSW |
1 |
92,525,113 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4701:Or9s15
|
UTSW |
1 |
92,525,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Or9s15
|
UTSW |
1 |
92,524,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4802:Or9s15
|
UTSW |
1 |
92,524,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6564:Or9s15
|
UTSW |
1 |
92,524,285 (GRCm39) |
missense |
probably benign |
|
|
R7082:Or9s15
|
UTSW |
1 |
92,524,140 (GRCm39) |
start gained |
probably benign |
|
|
R7349:Or9s15
|
UTSW |
1 |
92,524,904 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7589:Or9s15
|
UTSW |
1 |
92,524,781 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8816:Or9s15
|
UTSW |
1 |
92,524,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Or9s15
|
UTSW |
1 |
92,524,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Or9s15
|
UTSW |
1 |
92,524,996 (GRCm39) |
missense |
probably benign |
|
|
R9267:Or9s15
|
UTSW |
1 |
92,524,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Or9s15
|
UTSW |
1 |
92,524,988 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2014-05-07 |
Incidental Mutation