Incidental Mutation 'IGL02011:Olfr1411'
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ID183355
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1411
Ensembl Gene ENSMUSG00000062497
Gene Nameolfactory receptor 1411
SynonymsGA_x6K02T2R7CC-81157497-81156526, MOR208-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL02011
Quality Score
Status
Chromosome1
Chromosomal Location92594411-92597753 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 92596899 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Asparagine at position 127 (Y127N)
Ref Sequence ENSEMBL: ENSMUSP00000150254 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073748] [ENSMUST00000190844] [ENSMUST00000216444]
Predicted Effect probably damaging
Transcript: ENSMUST00000073748
AA Change: Y127N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073422
Gene: ENSMUSG00000062497
AA Change: Y127N

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.4e-53 PFAM
Pfam:7tm_1 48 297 1.2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000190844
AA Change: Y127N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140373
Gene: ENSMUSG00000062497
AA Change: Y127N

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
low complexity region 32 44 N/A INTRINSIC
Pfam:7tm_1 48 297 6.7e-25 PFAM
Pfam:7tm_4 146 290 2.9e-45 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203299
Predicted Effect probably damaging
Transcript: ENSMUST00000216444
AA Change: Y127N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap5m1 T A 14: 49,081,135 probably benign Het
Arg1 T C 10: 24,916,377 T215A probably benign Het
Arhgap15 A T 2: 43,780,755 K50N probably damaging Het
Ctdsp1 C T 1: 74,394,016 probably benign Het
Cwc22 A T 2: 77,921,022 D363E possibly damaging Het
Drd2 G T 9: 49,406,958 C400F probably damaging Het
Eef1akmt1 A T 14: 57,558,098 Y65N probably damaging Het
Gbp10 C A 5: 105,221,101 G291W probably damaging Het
Lrit1 T A 14: 37,062,323 V536E probably damaging Het
Olfr464 C A 11: 87,914,882 W8L probably benign Het
Olfr599 G T 7: 103,338,849 R265L probably damaging Het
Pcdh12 C T 18: 38,281,420 G884D probably damaging Het
Pih1d1 G T 7: 45,156,732 A31S probably damaging Het
Plcxd2 T C 16: 45,965,091 D317G probably damaging Het
Prkaca T C 8: 83,990,936 F231S probably damaging Het
Raet1d T A 10: 22,371,574 I183K probably damaging Het
Scaper A G 9: 55,580,322 F752S probably damaging Het
Shisa9 C T 16: 12,244,638 T241I possibly damaging Het
Taar9 C T 10: 24,108,579 R319H possibly damaging Het
Unkl T A 17: 25,218,591 V365E probably damaging Het
Usp34 C T 11: 23,471,554 S3077F probably damaging Het
Vps16 A G 2: 130,441,479 I566V probably benign Het
Vrk2 T A 11: 26,471,717 T414S probably benign Het
Xpnpep1 A T 19: 53,002,465 probably benign Het
Zfp804a A G 2: 82,256,691 Q288R probably damaging Het
Other mutations in Olfr1411
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01382:Olfr1411 APN 1 92597200 missense possibly damaging 0.46
PIT4810001:Olfr1411 UTSW 1 92597154 missense probably benign 0.04
R2036:Olfr1411 UTSW 1 92596606 missense probably benign 0.19
R2044:Olfr1411 UTSW 1 92596969 missense probably benign 0.00
R4133:Olfr1411 UTSW 1 92596743 missense probably benign 0.09
R4406:Olfr1411 UTSW 1 92597314 missense possibly damaging 0.90
R4568:Olfr1411 UTSW 1 92597391 missense probably benign 0.09
R4701:Olfr1411 UTSW 1 92597438 missense probably benign 0.00
R4801:Olfr1411 UTSW 1 92596998 missense probably benign 0.01
R4802:Olfr1411 UTSW 1 92596998 missense probably benign 0.01
R6564:Olfr1411 UTSW 1 92596563 missense probably benign
R7082:Olfr1411 UTSW 1 92596418 start gained probably benign
R7349:Olfr1411 UTSW 1 92597182 missense possibly damaging 0.95
R7589:Olfr1411 UTSW 1 92597059 missense probably benign 0.00
Z1177:Olfr1411 UTSW 1 92597266 missense probably damaging 0.98
Posted On2014-05-07