Incidental Mutation 'IGL00886:Olfr309'
ID27748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr309
Ensembl Gene ENSMUSG00000054054
Gene Nameolfactory receptor 309
SynonymsGA_x6K02T2NHDJ-9801340-9802266, MOR251-4P
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL00886
Quality Score
Status
Chromosome7
Chromosomal Location86304474-86313708 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 86307051 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 21 (L21F)
Ref Sequence ENSEMBL: ENSMUSP00000134377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055690] [ENSMUST00000174158]
Predicted Effect probably damaging
Transcript: ENSMUST00000055690
AA Change: L21F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000061929
Gene: ENSMUSG00000054054
AA Change: L21F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 303 4.5e-11 PFAM
Pfam:7tm_1 39 288 1.5e-26 PFAM
Pfam:7tm_4 137 281 7.9e-44 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174158
AA Change: L21F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000134377
Gene: ENSMUSG00000054054
AA Change: L21F

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.6e-55 PFAM
Pfam:7TM_GPCR_Srsx 33 303 4.5e-11 PFAM
Pfam:7tm_1 39 288 2.4e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 C T 11: 110,163,275 R67H possibly damaging Het
Ak4 G T 4: 101,447,189 E59* probably null Het
Ano10 T C 9: 122,271,324 N116S probably benign Het
Arid1b T A 17: 5,126,979 H658Q probably damaging Het
Atf2 G A 2: 73,845,503 T208I possibly damaging Het
Bco1 T C 8: 117,130,637 W448R probably damaging Het
Cel A T 2: 28,559,385 C277S probably damaging Het
Chd5 T A 4: 152,359,699 D296E probably benign Het
Crygd C T 1: 65,062,091 R115Q probably benign Het
Fmo9 T C 1: 166,680,145 probably null Het
Gdpgp1 T G 7: 80,239,352 L377R probably damaging Het
Gm26938 T A 5: 139,826,336 D3V probably damaging Het
Gpld1 T A 13: 24,962,353 Y193* probably null Het
Gtf2h4 T C 17: 35,669,982 H265R probably damaging Het
Hadh G T 3: 131,249,816 T83K probably benign Het
Hao1 T C 2: 134,523,159 M183V probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Ift88 T C 14: 57,478,068 Y523H probably damaging Het
Il23r G T 6: 67,473,890 Q202K possibly damaging Het
Iyd T C 10: 3,540,444 D50A probably benign Het
Katnal2 A T 18: 77,002,754 L248Q probably damaging Het
Krtap26-1 A T 16: 88,647,379 V118E possibly damaging Het
Lzic T C 4: 149,493,296 probably null Het
Mical2 T A 7: 112,315,072 N316K probably benign Het
Ndufc2 T A 7: 97,400,190 M1K probably null Het
Net1 A G 13: 3,893,391 probably benign Het
Pde1c A G 6: 56,173,674 Y287H probably damaging Het
Pitpnm1 T C 19: 4,110,665 probably null Het
Pla2r1 T A 2: 60,424,324 E1300V probably damaging Het
Polr3g T C 13: 81,694,677 Y73C probably damaging Het
Ryr1 T A 7: 29,024,229 E4137V probably damaging Het
Scrib T C 15: 76,048,794 D1425G possibly damaging Het
Slc25a12 A G 2: 71,344,032 Y23H possibly damaging Het
Spef2 C A 15: 9,663,095 G867W probably damaging Het
Strn3 A T 12: 51,610,150 Y698N probably damaging Het
Tldc1 T C 8: 119,773,268 probably benign Het
Ube3a T A 7: 59,284,737 F533I probably damaging Het
Other mutations in Olfr309
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0370:Olfr309 UTSW 7 86306849 missense probably benign 0.42
R1869:Olfr309 UTSW 7 86306667 missense possibly damaging 0.96
R2047:Olfr309 UTSW 7 86306804 missense probably damaging 1.00
R3939:Olfr309 UTSW 7 86306229 missense probably benign 0.00
R4562:Olfr309 UTSW 7 86307152 start gained probably benign
R4640:Olfr309 UTSW 7 86307066 missense probably benign 0.01
R4811:Olfr309 UTSW 7 86306958 missense probably benign 0.41
R4867:Olfr309 UTSW 7 86306283 missense probably benign 0.00
R4954:Olfr309 UTSW 7 86306601 missense probably benign 0.01
R5784:Olfr309 UTSW 7 86306535 missense probably damaging 1.00
R6043:Olfr309 UTSW 7 86306339 missense probably damaging 0.97
R6498:Olfr309 UTSW 7 86307018 missense probably benign
R6849:Olfr309 UTSW 7 86307040 missense possibly damaging 0.54
R7238:Olfr309 UTSW 7 86306591 missense probably damaging 1.00
R7811:Olfr309 UTSW 7 86306346 missense probably damaging 1.00
T0975:Olfr309 UTSW 7 86306284 nonsense probably null
Posted On2013-04-17