Incidental Mutation 'IGL02117:Mrgprx1'
ID280442
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgprx1
Ensembl Gene ENSMUSG00000070552
Gene NameMAS-related GPR, member X1
SynonymsMrgprc11, MrgC11
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02117
Quality Score
Status
Chromosome7
Chromosomal Location48020971-48027597 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to T at 48021623 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 125 (C125*)
Ref Sequence ENSEMBL: ENSMUSP00000091954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094390]
Predicted Effect probably null
Transcript: ENSMUST00000094390
AA Change: C125*
SMART Domains Protein: ENSMUSP00000091954
Gene: ENSMUSG00000070552
AA Change: C125*

DomainStartEndE-ValueType
Pfam:7tm_1 43 202 1.9e-7 PFAM
low complexity region 227 245 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T A 2: 151,473,546 M71L probably benign Het
Abcb11 A G 2: 69,323,825 probably benign Het
Ago4 T C 4: 126,516,852 T249A probably benign Het
Ahr A T 12: 35,512,923 C92* probably null Het
Arhgap17 G A 7: 123,286,773 probably benign Het
Arid1a G T 4: 133,692,815 T992K unknown Het
Camk2a A G 18: 60,977,989 I83M probably damaging Het
Ccdc154 T C 17: 25,167,818 probably null Het
Chtf18 T C 17: 25,722,203 H607R possibly damaging Het
Col25a1 T C 3: 130,519,773 probably benign Het
Col9a1 C T 1: 24,237,493 Q530* probably null Het
Cryl1 G T 14: 57,286,447 D219E probably damaging Het
Cul3 A T 1: 80,323,064 probably benign Het
Cul9 C A 17: 46,540,375 R373L probably benign Het
Exo1 A G 1: 175,893,743 Y316C possibly damaging Het
Fam114a1 G A 5: 65,030,122 V408M probably benign Het
Hmcn2 A T 2: 31,457,173 S4792C possibly damaging Het
Hps5 A G 7: 46,783,516 F260S probably damaging Het
Hrh4 T C 18: 13,022,420 S339P probably benign Het
Ist1 A T 8: 109,678,952 L152Q probably damaging Het
Marco A G 1: 120,490,954 V190A probably benign Het
Mdn1 T C 4: 32,709,364 V1711A probably benign Het
Mmp9 A G 2: 164,949,724 Y179C probably damaging Het
Mrgprb5 A G 7: 48,168,994 probably benign Het
Msh6 A G 17: 87,990,806 probably benign Het
Myot C A 18: 44,355,110 R441S probably benign Het
Olfr740 A G 14: 50,453,942 R297G possibly damaging Het
Paf1 A G 7: 28,398,690 probably benign Het
Pde11a A G 2: 75,991,262 L891P probably damaging Het
Prkar2a T A 9: 108,719,261 I135N probably damaging Het
Rap1gap C T 4: 137,727,044 T646M probably damaging Het
Rgs7bp T C 13: 104,951,579 D229G possibly damaging Het
Rhobtb3 C T 13: 75,877,428 S523N probably damaging Het
Setd7 A T 3: 51,521,405 Y335N probably damaging Het
Setdb2 C T 14: 59,402,315 R709Q probably damaging Het
Socs4 T C 14: 47,290,807 Y400H probably damaging Het
Spag16 A T 1: 69,870,320 H192L probably damaging Het
Ssh1 A T 5: 113,946,480 C566* probably null Het
Stap1 T G 5: 86,086,693 I98S possibly damaging Het
Tgs1 C T 4: 3,585,836 H238Y probably damaging Het
Tifab T C 13: 56,176,462 Y56C probably benign Het
Tssk2 A G 16: 17,899,789 E352G probably benign Het
Vmn2r57 A T 7: 41,400,450 V625D probably benign Het
Wbp1l T C 19: 46,644,437 Y75H probably benign Het
Wnt5a T C 14: 28,506,120 probably benign Het
Other mutations in Mrgprx1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Mrgprx1 APN 7 48021486 missense probably benign 0.00
IGL01326:Mrgprx1 APN 7 48021769 missense probably benign 0.26
IGL02219:Mrgprx1 APN 7 48021729 missense probably benign 0.20
IGL02431:Mrgprx1 APN 7 48021127 missense probably benign 0.00
IGL02441:Mrgprx1 APN 7 48021588 missense probably benign 0.39
IGL02682:Mrgprx1 APN 7 48021992 missense probably damaging 1.00
R0219:Mrgprx1 UTSW 7 48021546 missense probably damaging 1.00
R4366:Mrgprx1 UTSW 7 48021193 missense probably damaging 0.98
R4521:Mrgprx1 UTSW 7 48021699 missense probably benign
R4801:Mrgprx1 UTSW 7 48021211 missense possibly damaging 0.89
R4802:Mrgprx1 UTSW 7 48021211 missense possibly damaging 0.89
R5452:Mrgprx1 UTSW 7 48021808 missense probably benign 0.07
R5537:Mrgprx1 UTSW 7 48021150 missense probably benign
R6444:Mrgprx1 UTSW 7 48021814 missense possibly damaging 0.87
R6834:Mrgprx1 UTSW 7 48021637 missense probably damaging 0.99
R7406:Mrgprx1 UTSW 7 48021985 missense possibly damaging 0.62
RF020:Mrgprx1 UTSW 7 48021511 small insertion probably benign
RF024:Mrgprx1 UTSW 7 48021511 small insertion probably benign
RF026:Mrgprx1 UTSW 7 48021509 small insertion probably benign
RF043:Mrgprx1 UTSW 7 48021509 small insertion probably benign
Z1088:Mrgprx1 UTSW 7 48021129 missense probably damaging 0.98
Posted On2015-04-16