Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02307:Mrgprb2'

287658

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgprb2

Ensembl Gene

ENSMUSG00000050425

Gene Name

MAS-related GPR, member B2

Synonyms

4833406I20Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02307

Quality Score

Status

Chromosome

Chromosomal Location

48200713-48207834 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 48202644 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 27 (Y27F)

Ref Sequence

ENSEMBL: ENSMUSP00000061878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052730]

AlphaFold

Q3KNA1

Predicted Effect

probably benign
Transcript: ENSMUST00000052730
AA Change: Y27F

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000061878
Gene: ENSMUSG00000050425
AA Change: Y27F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	54	286	2.1e-7	PFAM
low complexity region	293	308	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired mast cell activation and inflammatory response after 48/80 treatment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 121,935,395 (GRCm39)	D323G	probably damaging	Het
Ankrd28	A	G	14: 31,455,665 (GRCm39)	C417R	probably damaging	Het
Astn1	C	T	1: 158,502,184 (GRCm39)	R1133C	probably damaging	Het
Bdp1	C	A	13: 100,229,946 (GRCm39)	G256V	probably damaging	Het
Cald1	A	G	6: 34,730,390 (GRCm39)	K252E	probably damaging	Het
Ccdc141	T	C	2: 76,859,686 (GRCm39)	E985G	probably damaging	Het
Cdc23	A	G	18: 34,774,442 (GRCm39)	I279T	possibly damaging	Het
Col16a1	C	T	4: 129,952,802 (GRCm39)	P416L	probably damaging	Het
Coro1a	T	C	7: 126,300,736 (GRCm39)	D197G	probably damaging	Het
Ctnnd2	C	T	15: 30,647,357 (GRCm39)	T351I	possibly damaging	Het
Fam76b	A	G	9: 13,755,332 (GRCm39)	N313S	probably damaging	Het
Fbxw20	C	A	9: 109,062,601 (GRCm39)	W75L	possibly damaging	Het
Gjd2	T	C	2: 113,842,394 (GRCm39)	T28A	possibly damaging	Het
Glyctk	A	C	9: 106,032,963 (GRCm39)	L350R	possibly damaging	Het
Gm20726	A	T	14: 54,870,060 (GRCm39)	V237D	probably damaging	Het
Gm57858	T	C	3: 36,073,016 (GRCm39)	K422R	possibly damaging	Het
Gpr22	C	A	12: 31,758,739 (GRCm39)	C461F	possibly damaging	Het
Grhl2	A	G	15: 37,288,532 (GRCm39)	T279A	probably damaging	Het
Gstm3	G	A	3: 107,874,929 (GRCm39)	R108C	probably damaging	Het
Haus6	T	C	4: 86,502,072 (GRCm39)	T600A	possibly damaging	Het
Htra4	G	A	8: 25,523,710 (GRCm39)	A285V	probably damaging	Het
Igkv14-100	C	T	6: 68,496,349 (GRCm39)	P81S	probably damaging	Het
Kif24	T	G	4: 41,395,274 (GRCm39)	Q533P	probably benign	Het
Klhl1	A	T	14: 96,438,809 (GRCm39)	N496K	possibly damaging	Het
Lama3	G	T	18: 12,714,840 (GRCm39)	R1667L	probably benign	Het
Lct	T	A	1: 128,214,327 (GRCm39)	H1815L	possibly damaging	Het
Mrpl15	A	T	1: 4,854,176 (GRCm39)	H86Q	possibly damaging	Het
Myo10	C	T	15: 25,776,401 (GRCm39)		probably benign	Het
Nrp1	T	C	8: 129,229,201 (GRCm39)	L893P	probably damaging	Het
Or4n4b	A	C	14: 50,536,295 (GRCm39)	I157S	probably damaging	Het
Or51a8	A	T	7: 102,550,086 (GRCm39)	N171Y	probably benign	Het
Ovol1	T	A	19: 5,603,643 (GRCm39)	D86V	possibly damaging	Het
Pacs2	T	A	12: 113,034,393 (GRCm39)	M851K	probably damaging	Het
Pde1a	A	T	2: 79,736,412 (GRCm39)	M39K	possibly damaging	Het
Pdpn	T	C	4: 143,000,550 (GRCm39)	H94R	possibly damaging	Het
Plcg2	T	A	8: 118,306,635 (GRCm39)		probably null	Het
Pzp	A	T	6: 128,466,049 (GRCm39)	Y1210*	probably null	Het
Rnf148	G	T	6: 23,654,890 (GRCm39)	S35R	probably benign	Het
Ros1	A	T	10: 52,004,534 (GRCm39)	S1008T	possibly damaging	Het
Rps18-ps6	G	T	13: 97,896,871 (GRCm39)	Q76K	probably benign	Het
Sis	A	T	3: 72,819,167 (GRCm39)		probably benign	Het
Spag9	T	A	11: 93,992,986 (GRCm39)		probably null	Het
Srbd1	A	G	17: 86,433,616 (GRCm39)	L327P	probably damaging	Het
Steap3	A	T	1: 120,169,390 (GRCm39)	Y264*	probably null	Het
Swap70	A	G	7: 109,880,501 (GRCm39)	E572G	probably benign	Het
Traf7	C	A	17: 24,732,020 (GRCm39)	C193F	possibly damaging	Het
Trmt11	T	C	10: 30,470,150 (GRCm39)	D58G	possibly damaging	Het
Tsc22d1	T	C	14: 76,653,901 (GRCm39)	S127P	probably damaging	Het
Usf1	T	A	1: 171,243,314 (GRCm39)	S30R	probably damaging	Het
Ush1c	A	G	7: 45,846,612 (GRCm39)		probably benign	Het
Utrn	A	T	10: 12,625,809 (GRCm39)	L124*	probably null	Het
Vmn2r75	T	C	7: 85,814,974 (GRCm39)	N173S	probably benign	Het
Zic2	T	C	14: 122,714,046 (GRCm39)	V320A	possibly damaging	Het

Other mutations in Mrgprb2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01311:Mrgprb2	APN	7	48,201,746 (GRCm39)	missense	probably benign	0.29
IGL01509:Mrgprb2	APN	7	48,202,674 (GRCm39)	missense	possibly damaging	0.70
IGL01978:Mrgprb2	APN	7	48,202,312 (GRCm39)	missense	probably damaging	0.98
IGL02726:Mrgprb2	APN	7	48,202,618 (GRCm39)	missense	probably damaging	0.97
IGL03393:Mrgprb2	APN	7	48,202,650 (GRCm39)	missense	probably benign	0.13
R0190:Mrgprb2	UTSW	7	48,202,525 (GRCm39)	missense	possibly damaging	0.95
R0334:Mrgprb2	UTSW	7	48,202,077 (GRCm39)	missense	probably damaging	1.00
R0514:Mrgprb2	UTSW	7	48,201,718 (GRCm39)	missense	probably benign	0.05
R2177:Mrgprb2	UTSW	7	48,202,128 (GRCm39)	missense	probably benign	0.11
R2932:Mrgprb2	UTSW	7	48,202,194 (GRCm39)	missense	probably benign	0.17
R3417:Mrgprb2	UTSW	7	48,202,281 (GRCm39)	missense	probably damaging	0.98
R3953:Mrgprb2	UTSW	7	48,202,116 (GRCm39)	missense	possibly damaging	0.78
R5673:Mrgprb2	UTSW	7	48,202,121 (GRCm39)	missense	probably benign	0.00
R5733:Mrgprb2	UTSW	7	48,202,261 (GRCm39)	missense	probably benign	0.01
R5890:Mrgprb2	UTSW	7	48,201,707 (GRCm39)	makesense	probably null
R5915:Mrgprb2	UTSW	7	48,202,554 (GRCm39)	missense	probably benign	0.14
R6147:Mrgprb2	UTSW	7	48,202,113 (GRCm39)	missense	possibly damaging	0.64
R6381:Mrgprb2	UTSW	7	48,202,138 (GRCm39)	missense	probably benign	0.01
R6414:Mrgprb2	UTSW	7	48,202,129 (GRCm39)	missense	probably benign	0.01
R6965:Mrgprb2	UTSW	7	48,202,597 (GRCm39)	missense	probably damaging	0.97
R7017:Mrgprb2	UTSW	7	48,202,585 (GRCm39)	missense	probably benign	0.08
R7341:Mrgprb2	UTSW	7	48,202,644 (GRCm39)	missense	probably benign	0.01
R7399:Mrgprb2	UTSW	7	48,201,890 (GRCm39)	missense	probably damaging	1.00
R8168:Mrgprb2	UTSW	7	48,201,767 (GRCm39)	missense	probably benign	0.26
R8189:Mrgprb2	UTSW	7	48,202,502 (GRCm39)	nonsense	probably null
R8738:Mrgprb2	UTSW	7	48,202,648 (GRCm39)	missense	probably benign	0.04
R9160:Mrgprb2	UTSW	7	48,201,982 (GRCm39)	missense	possibly damaging	0.82
R9210:Mrgprb2	UTSW	7	48,202,392 (GRCm39)	missense	possibly damaging	0.91
R9212:Mrgprb2	UTSW	7	48,202,392 (GRCm39)	missense	possibly damaging	0.91
R9308:Mrgprb2	UTSW	7	48,202,655 (GRCm39)	missense	possibly damaging	0.86
R9562:Mrgprb2	UTSW	7	48,202,674 (GRCm39)	missense	possibly damaging	0.70
R9565:Mrgprb2	UTSW	7	48,202,674 (GRCm39)	missense	possibly damaging	0.70
R9763:Mrgprb2	UTSW	7	48,202,174 (GRCm39)	missense	probably benign	0.00
Z1177:Mrgprb2	UTSW	7	48,202,721 (GRCm39)	start codon destroyed	probably null

Posted On

2015-04-16