Incidental Mutation 'IGL02316:Zcwpw1'
| ID |
288051 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zcwpw1
|
| Ensembl Gene |
ENSMUSG00000037108 |
| Gene Name |
zinc finger, CW type with PWWP domain 1 |
| Synonyms |
LOC381678 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.139)
|
| Stock # |
IGL02316
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
137786060-137820883 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 137808272 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035852]
|
| AlphaFold |
Q6IR42 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035852
|
| SMART Domains |
Protein: ENSMUSP00000048730
Gene: ENSMUSG00000037108
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:zf-CW
|
246 |
293 |
7.3e-18 |
PFAM |
|
Pfam:PWWP
|
306 |
401 |
6.9e-22 |
PFAM |
|
coiled coil region
|
440 |
462 |
N/A |
INTRINSIC |
|
low complexity region
|
587 |
598 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128946
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141642
|
| SMART Domains |
Protein: ENSMUSP00000120909
Gene: ENSMUSG00000037108
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:PWWP
|
21 |
109 |
8.2e-19 |
PFAM |
|
coiled coil region
|
126 |
148 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akr1c13 |
G |
T |
13: 4,253,458 (GRCm39) |
|
probably benign |
Het |
| Arhgap26 |
C |
T |
18: 38,775,599 (GRCm39) |
|
noncoding transcript |
Het |
| Atp5f1b |
T |
C |
10: 127,920,178 (GRCm39) |
V108A |
probably benign |
Het |
| B230307C23Rik |
G |
A |
16: 97,809,850 (GRCm39) |
V9M |
probably damaging |
Het |
| Ccdc85c |
T |
A |
12: 108,177,829 (GRCm39) |
H321L |
probably damaging |
Het |
| Diaph3 |
A |
T |
14: 87,223,551 (GRCm39) |
M321K |
possibly damaging |
Het |
| Dicer1 |
G |
A |
12: 104,668,812 (GRCm39) |
A1290V |
probably damaging |
Het |
| Dnah6 |
G |
A |
6: 73,145,894 (GRCm39) |
T839M |
probably benign |
Het |
| Eif3a |
G |
A |
19: 60,760,076 (GRCm39) |
|
probably benign |
Het |
| Eml1 |
T |
C |
12: 108,501,018 (GRCm39) |
|
probably benign |
Het |
| Exoc4 |
A |
G |
6: 33,887,519 (GRCm39) |
Q769R |
probably damaging |
Het |
| Fam184a |
T |
G |
10: 53,514,335 (GRCm39) |
T426P |
probably damaging |
Het |
| Fsip2 |
C |
A |
2: 82,809,137 (GRCm39) |
H1819N |
probably benign |
Het |
| Gm6686 |
T |
A |
17: 15,786,500 (GRCm39) |
|
probably benign |
Het |
| Hadha |
T |
C |
5: 30,331,565 (GRCm39) |
S464G |
probably benign |
Het |
| Ighv5-17 |
A |
T |
12: 113,822,775 (GRCm39) |
C115* |
probably null |
Het |
| Jmjd6 |
T |
C |
11: 116,733,928 (GRCm39) |
Y31C |
possibly damaging |
Het |
| Klrb1-ps1 |
G |
A |
6: 129,093,532 (GRCm39) |
|
noncoding transcript |
Het |
| Mgat1 |
T |
C |
11: 49,152,185 (GRCm39) |
Y223H |
probably damaging |
Het |
| Muc4 |
T |
C |
16: 32,569,668 (GRCm39) |
S243P |
possibly damaging |
Het |
| Numa1 |
T |
C |
7: 101,650,577 (GRCm39) |
L69P |
probably damaging |
Het |
| Or11h6 |
T |
C |
14: 50,879,744 (GRCm39) |
I2T |
probably benign |
Het |
| Or1j21 |
A |
T |
2: 36,683,632 (GRCm39) |
H128L |
probably damaging |
Het |
| Or1j4 |
C |
A |
2: 36,740,294 (GRCm39) |
P79T |
probably damaging |
Het |
| Or4p23 |
A |
G |
2: 88,577,187 (GRCm39) |
F15S |
probably damaging |
Het |
| Pde1c |
A |
T |
6: 56,128,336 (GRCm39) |
D332E |
possibly damaging |
Het |
| Pitpnm1 |
A |
G |
19: 4,162,835 (GRCm39) |
I1143V |
probably benign |
Het |
| Rsl1 |
T |
A |
13: 67,325,120 (GRCm39) |
|
probably null |
Het |
| Scg2 |
A |
C |
1: 79,413,398 (GRCm39) |
L442V |
probably damaging |
Het |
| Sez6l |
A |
T |
5: 112,610,828 (GRCm39) |
V530E |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,200,489 (GRCm39) |
I4655T |
possibly damaging |
Het |
|
| Other mutations in Zcwpw1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01296:Zcwpw1
|
APN |
5 |
137,795,061 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL02336:Zcwpw1
|
APN |
5 |
137,808,376 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0103:Zcwpw1
|
UTSW |
5 |
137,808,375 (GRCm39) |
nonsense |
probably null |
|
|
R0103:Zcwpw1
|
UTSW |
5 |
137,808,375 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Zcwpw1
|
UTSW |
5 |
137,815,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Zcwpw1
|
UTSW |
5 |
137,794,945 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0685:Zcwpw1
|
UTSW |
5 |
137,797,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0698:Zcwpw1
|
UTSW |
5 |
137,815,783 (GRCm39) |
missense |
probably benign |
|
|
R0727:Zcwpw1
|
UTSW |
5 |
137,809,069 (GRCm39) |
unclassified |
probably benign |
|
|
R1677:Zcwpw1
|
UTSW |
5 |
137,795,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1780:Zcwpw1
|
UTSW |
5 |
137,794,914 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1938:Zcwpw1
|
UTSW |
5 |
137,809,884 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2875:Zcwpw1
|
UTSW |
5 |
137,808,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Zcwpw1
|
UTSW |
5 |
137,798,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5073:Zcwpw1
|
UTSW |
5 |
137,793,781 (GRCm39) |
start codon destroyed |
probably null |
0.81 |
|
R5913:Zcwpw1
|
UTSW |
5 |
137,798,269 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6224:Zcwpw1
|
UTSW |
5 |
137,810,298 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6542:Zcwpw1
|
UTSW |
5 |
137,810,282 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7204:Zcwpw1
|
UTSW |
5 |
137,810,346 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7542:Zcwpw1
|
UTSW |
5 |
137,817,785 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7600:Zcwpw1
|
UTSW |
5 |
137,798,396 (GRCm39) |
nonsense |
probably null |
|
|
R7911:Zcwpw1
|
UTSW |
5 |
137,795,032 (GRCm39) |
missense |
probably null |
1.00 |
|
R7972:Zcwpw1
|
UTSW |
5 |
137,799,323 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7988:Zcwpw1
|
UTSW |
5 |
137,815,753 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8174:Zcwpw1
|
UTSW |
5 |
137,817,839 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8713:Zcwpw1
|
UTSW |
5 |
137,797,794 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8851:Zcwpw1
|
UTSW |
5 |
137,820,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Zcwpw1
|
UTSW |
5 |
137,798,340 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9131:Zcwpw1
|
UTSW |
5 |
137,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9337:Zcwpw1
|
UTSW |
5 |
137,799,274 (GRCm39) |
missense |
probably benign |
0.37 |
|
X0021:Zcwpw1
|
UTSW |
5 |
137,809,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation