Incidental Mutation 'IGL02510:Olfr488'
ID296520
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr488
Ensembl Gene ENSMUSG00000096465
Gene Nameolfactory receptor 488
SynonymsGA_x6K02T2PBJ9-10586187-10585243, MOR204-15
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.360) question?
Stock #IGL02510
Quality Score
Status
Chromosome7
Chromosomal Location108251617-108258347 bp(-) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) T to A at 108256141 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072968] [ENSMUST00000211345] [ENSMUST00000211508] [ENSMUST00000215173]
Predicted Effect probably benign
Transcript: ENSMUST00000072968
SMART Domains Protein: ENSMUSP00000072735
Gene: ENSMUSG00000096465

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.7e-53 PFAM
Pfam:7tm_1 44 293 2.6e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211345
Predicted Effect probably benign
Transcript: ENSMUST00000211508
Predicted Effect probably benign
Transcript: ENSMUST00000215173
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts4 G A 1: 171,251,390 S193N probably benign Het
Arrdc1 C A 2: 24,935,100 V16F probably damaging Het
Bsx A T 9: 40,874,221 Q15L possibly damaging Het
Casp8ap2 A G 4: 32,639,704 T253A probably benign Het
Cdkl3 T C 11: 52,011,270 L102P probably damaging Het
Cgnl1 G T 9: 71,725,357 N237K probably benign Het
Cldn14 T A 16: 93,919,956 M1L probably damaging Het
Col1a2 C T 6: 4,516,398 R171C unknown Het
Col7a1 C A 9: 108,973,231 probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dhrs2 G A 14: 55,236,075 V64M probably damaging Het
Disp3 G A 4: 148,252,701 H886Y probably benign Het
Dst G A 1: 34,229,251 probably null Het
Fnbp4 T C 2: 90,751,475 V215A probably benign Het
Fzd9 A G 5: 135,249,615 L472P probably damaging Het
Gm5096 A G 18: 87,757,529 Q392R probably benign Het
Hpd C T 5: 123,181,910 R15Q possibly damaging Het
Htra2 A G 6: 83,051,611 V412A probably damaging Het
Ift80 A G 3: 68,898,543 F722S probably benign Het
Kcnq2 T C 2: 181,081,361 T741A probably benign Het
Kl A C 5: 150,989,001 E738D probably damaging Het
Klra4 T A 6: 130,059,543 I178L probably damaging Het
Klra9 T C 6: 130,191,222 E27G probably benign Het
Kntc1 T C 5: 123,819,062 Y2145H probably benign Het
Mbd5 T A 2: 49,257,029 M417K probably benign Het
Med31 C T 11: 72,212,056 M75I probably benign Het
Mpeg1 A T 19: 12,461,424 D82V probably damaging Het
Msto1 A G 3: 88,910,345 Y439H probably damaging Het
Olfr23 G A 11: 73,941,005 G253E probably damaging Het
Olfr332 T C 11: 58,490,539 Y72C probably damaging Het
Olfr344 T C 2: 36,568,681 S28P possibly damaging Het
Prtg G A 9: 72,890,869 V706M probably damaging Het
Sfxn2 G T 19: 46,588,272 A186S probably benign Het
Slc12a5 A T 2: 164,982,808 probably benign Het
Slc7a3 T C X: 101,082,833 E222G probably benign Het
Stox1 A T 10: 62,664,047 H911Q probably benign Het
Sult3a2 A T 10: 33,766,439 N289K probably benign Het
Supt20 A G 3: 54,715,524 probably benign Het
Tchh A G 3: 93,444,078 E275G unknown Het
Tectb A T 19: 55,191,511 N263I probably damaging Het
Tsga10 C T 1: 37,760,985 R608Q possibly damaging Het
Ttyh3 A G 5: 140,629,464 Y390H probably damaging Het
Utf1 C A 7: 139,944,016 S48* probably null Het
Zfp358 G A 8: 3,496,786 G456D probably benign Het
Zufsp A G 10: 33,930,154 probably null Het
Other mutations in Olfr488
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Olfr488 APN 7 108255535 missense possibly damaging 0.89
IGL02943:Olfr488 APN 7 108255416 missense possibly damaging 0.80
IGL02962:Olfr488 APN 7 108255703 missense possibly damaging 0.78
PIT4472001:Olfr488 UTSW 7 108256103 missense possibly damaging 0.46
R0980:Olfr488 UTSW 7 108256022 small deletion probably benign
R0981:Olfr488 UTSW 7 108256021 small deletion probably benign
R0981:Olfr488 UTSW 7 108256022 small deletion probably benign
R1957:Olfr488 UTSW 7 108255196 nonsense probably null
R3147:Olfr488 UTSW 7 108255676 missense possibly damaging 0.89
R4163:Olfr488 UTSW 7 108255832 missense probably benign 0.06
R4190:Olfr488 UTSW 7 108256123 missense probably benign
R4911:Olfr488 UTSW 7 108256037 missense possibly damaging 0.81
R5274:Olfr488 UTSW 7 108255635 missense probably benign 0.02
R5684:Olfr488 UTSW 7 108256039 missense possibly damaging 0.75
R6394:Olfr488 UTSW 7 108255763 missense possibly damaging 0.95
R6467:Olfr488 UTSW 7 108255902 missense probably damaging 0.99
R7173:Olfr488 UTSW 7 108255748 missense possibly damaging 0.78
R7317:Olfr488 UTSW 7 108255218 missense probably benign 0.00
R7348:Olfr488 UTSW 7 108256123 missense probably benign
R7485:Olfr488 UTSW 7 108255838 missense probably damaging 1.00
Posted On2015-04-16