Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02510:Olfr488'

296520

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr488

Ensembl Gene

ENSMUSG00000096465

Gene Name

olfactory receptor 488

Synonyms

GA_x6K02T2PBJ9-10586187-10585243, MOR204-15

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.360) question?

Stock #

IGL02510

Quality Score

Status

Chromosome

Chromosomal Location

108251617-108258347 bp(-) (GRCm38)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

T to A at 108256141 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149427 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072968] [ENSMUST00000211345] [ENSMUST00000211508] [ENSMUST00000215173]

Predicted Effect

probably benign
Transcript: ENSMUST00000072968

SMART Domains

Protein: ENSMUSP00000072735
Gene: ENSMUSG00000096465

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	5.7e-53	PFAM
Pfam:7tm_1	44	293	2.6e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211345

Predicted Effect

probably benign
Transcript: ENSMUST00000211508

Predicted Effect

probably benign
Transcript: ENSMUST00000215173

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts4	G	A	1: 171,251,390	S193N	probably benign	Het
Arrdc1	C	A	2: 24,935,100	V16F	probably damaging	Het
Bsx	A	T	9: 40,874,221	Q15L	possibly damaging	Het
Casp8ap2	A	G	4: 32,639,704	T253A	probably benign	Het
Cdkl3	T	C	11: 52,011,270	L102P	probably damaging	Het
Cgnl1	G	T	9: 71,725,357	N237K	probably benign	Het
Cldn14	T	A	16: 93,919,956	M1L	probably damaging	Het
Col1a2	C	T	6: 4,516,398	R171C	unknown	Het
Col7a1	C	A	9: 108,973,231		probably benign	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dhrs2	G	A	14: 55,236,075	V64M	probably damaging	Het
Disp3	G	A	4: 148,252,701	H886Y	probably benign	Het
Dst	G	A	1: 34,229,251		probably null	Het
Fnbp4	T	C	2: 90,751,475	V215A	probably benign	Het
Fzd9	A	G	5: 135,249,615	L472P	probably damaging	Het
Gm5096	A	G	18: 87,757,529	Q392R	probably benign	Het
Hpd	C	T	5: 123,181,910	R15Q	possibly damaging	Het
Htra2	A	G	6: 83,051,611	V412A	probably damaging	Het
Ift80	A	G	3: 68,898,543	F722S	probably benign	Het
Kcnq2	T	C	2: 181,081,361	T741A	probably benign	Het
Kl	A	C	5: 150,989,001	E738D	probably damaging	Het
Klra4	T	A	6: 130,059,543	I178L	probably damaging	Het
Klra9	T	C	6: 130,191,222	E27G	probably benign	Het
Kntc1	T	C	5: 123,819,062	Y2145H	probably benign	Het
Mbd5	T	A	2: 49,257,029	M417K	probably benign	Het
Med31	C	T	11: 72,212,056	M75I	probably benign	Het
Mpeg1	A	T	19: 12,461,424	D82V	probably damaging	Het
Msto1	A	G	3: 88,910,345	Y439H	probably damaging	Het
Olfr23	G	A	11: 73,941,005	G253E	probably damaging	Het
Olfr332	T	C	11: 58,490,539	Y72C	probably damaging	Het
Olfr344	T	C	2: 36,568,681	S28P	possibly damaging	Het
Prtg	G	A	9: 72,890,869	V706M	probably damaging	Het
Sfxn2	G	T	19: 46,588,272	A186S	probably benign	Het
Slc12a5	A	T	2: 164,982,808		probably benign	Het
Slc7a3	T	C	X: 101,082,833	E222G	probably benign	Het
Stox1	A	T	10: 62,664,047	H911Q	probably benign	Het
Sult3a2	A	T	10: 33,766,439	N289K	probably benign	Het
Supt20	A	G	3: 54,715,524		probably benign	Het
Tchh	A	G	3: 93,444,078	E275G	unknown	Het
Tectb	A	T	19: 55,191,511	N263I	probably damaging	Het
Tsga10	C	T	1: 37,760,985	R608Q	possibly damaging	Het
Ttyh3	A	G	5: 140,629,464	Y390H	probably damaging	Het
Utf1	C	A	7: 139,944,016	S48*	probably null	Het
Zfp358	G	A	8: 3,496,786	G456D	probably benign	Het
Zufsp	A	G	10: 33,930,154		probably null	Het

Other mutations in Olfr488

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01575:Olfr488	APN	7	108255535	missense	possibly damaging	0.89
IGL02943:Olfr488	APN	7	108255416	missense	possibly damaging	0.80
IGL02962:Olfr488	APN	7	108255703	missense	possibly damaging	0.78
PIT4472001:Olfr488	UTSW	7	108256103	missense	possibly damaging	0.46
R0980:Olfr488	UTSW	7	108256022	small deletion	probably benign
R0981:Olfr488	UTSW	7	108256021	small deletion	probably benign
R0981:Olfr488	UTSW	7	108256022	small deletion	probably benign
R1957:Olfr488	UTSW	7	108255196	nonsense	probably null
R3147:Olfr488	UTSW	7	108255676	missense	possibly damaging	0.89
R4163:Olfr488	UTSW	7	108255832	missense	probably benign	0.06
R4190:Olfr488	UTSW	7	108256123	missense	probably benign
R4911:Olfr488	UTSW	7	108256037	missense	possibly damaging	0.81
R5274:Olfr488	UTSW	7	108255635	missense	probably benign	0.02
R5684:Olfr488	UTSW	7	108256039	missense	possibly damaging	0.75
R6394:Olfr488	UTSW	7	108255763	missense	possibly damaging	0.95
R6467:Olfr488	UTSW	7	108255902	missense	probably damaging	0.99
R7173:Olfr488	UTSW	7	108255748	missense	possibly damaging	0.78
R7317:Olfr488	UTSW	7	108255218	missense	probably benign	0.00
R7348:Olfr488	UTSW	7	108256123	missense	probably benign
R7485:Olfr488	UTSW	7	108255838	missense	probably damaging	1.00

Posted On

2015-04-16