Incidental Mutation 'IGL02567:Ifi202b'
ID 298856
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi202b
Ensembl Gene ENSMUSG00000026535
Gene Name interferon activated gene 202B
Synonyms p202
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL02567
Quality Score
Status
Chromosome 1
Chromosomal Location 173962568-173982744 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 173963804 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Asparagine at position 436 (S436N)
Ref Sequence ENSEMBL: ENSMUSP00000000266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000266]
AlphaFold Q9R002
PDB Structure Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000000266
AA Change: S436N

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: S436N

DomainStartEndE-ValueType
Pfam:HIN 58 223 4.1e-68 PFAM
Pfam:HIN 256 421 1.5e-61 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 C A 11: 53,372,751 S199R possibly damaging Het
Ano1 A G 7: 144,611,625 L621P probably damaging Het
Calcr C T 6: 3,691,564 V404M probably damaging Het
Carmil3 A G 14: 55,498,882 S635G possibly damaging Het
Ccl12 C A 11: 82,102,621 S28R possibly damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cdhr3 T C 12: 33,038,901 N761D probably benign Het
Col14a1 T C 15: 55,344,961 probably null Het
Col28a1 T C 6: 8,014,819 K862R possibly damaging Het
Cyp2c66 C T 19: 39,186,640 probably benign Het
D5Ertd615e T C 5: 45,163,416 noncoding transcript Het
Deup1 T C 9: 15,575,283 E367G probably damaging Het
Dpp8 T G 9: 65,078,776 Y849* probably null Het
Efhc1 T A 1: 20,972,964 V369E probably damaging Het
Epg5 A G 18: 78,033,073 Y2562C probably damaging Het
Fam189a1 T A 7: 64,786,731 M101L possibly damaging Het
Fbln5 A G 12: 101,761,800 probably null Het
Frem1 A T 4: 83,000,055 M551K probably damaging Het
Gba2 T C 4: 43,567,281 S889G probably benign Het
Golph3 C T 15: 12,349,421 R176* probably null Het
Got2 A T 8: 95,872,201 F191Y probably benign Het
Gtf2ird2 G T 5: 134,213,048 probably benign Het
Hist4h4 G A 6: 136,804,274 R36W probably damaging Het
Hivep3 A G 4: 120,133,956 T2218A probably damaging Het
Htr1f C T 16: 64,926,248 G227D probably benign Het
Nf1 T A 11: 79,547,143 V2109D probably damaging Het
Opa1 C A 16: 29,588,286 D29E probably benign Het
Papln C T 12: 83,778,837 P631S probably benign Het
Pde4c T A 8: 70,747,921 M352K probably benign Het
Pigu T C 2: 155,331,192 T129A possibly damaging Het
Pla2g4c T A 7: 13,346,040 H424Q probably damaging Het
Ptpn13 T G 5: 103,562,291 L1564R probably damaging Het
Rbm5 T C 9: 107,744,274 D642G probably damaging Het
Rnf111 T C 9: 70,459,005 T384A probably damaging Het
Scn11a T C 9: 119,804,489 T393A probably damaging Het
Sned1 A T 1: 93,274,347 K619M probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Syt9 A G 7: 107,436,661 Y295C probably damaging Het
Taar7f T A 10: 24,050,425 Y306N probably damaging Het
Tmem107 T G 11: 69,071,019 L25V possibly damaging Het
Wdr24 T G 17: 25,824,348 I48S probably damaging Het
Zc3hc1 T C 6: 30,374,849 D231G probably benign Het
Zfp142 T A 1: 74,578,147 S342C possibly damaging Het
Zfp142 T G 1: 74,578,149 K341T possibly damaging Het
Zfp142 T C 1: 74,578,150 K341E possibly damaging Het
Zfp804b T A 5: 6,769,989 I989L probably benign Het
Zfyve9 A C 4: 108,674,523 V1095G probably damaging Het
Other mutations in Ifi202b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Ifi202b APN 1 173971362 missense probably benign 0.00
IGL02019:Ifi202b APN 1 173974984 missense possibly damaging 0.95
IGL02466:Ifi202b APN 1 173972309 missense possibly damaging 0.71
IGL02508:Ifi202b APN 1 173974772 missense probably benign 0.18
IGL02644:Ifi202b APN 1 173971714 missense probably benign 0.00
R0282:Ifi202b UTSW 1 173977360 missense probably benign 0.00
R1178:Ifi202b UTSW 1 173972222 missense probably benign 0.02
R3414:Ifi202b UTSW 1 173963913 missense probably benign 0.19
R5739:Ifi202b UTSW 1 173971352 critical splice donor site probably null
R5944:Ifi202b UTSW 1 173963799 missense probably benign 0.00
R6805:Ifi202b UTSW 1 173974989 missense probably damaging 1.00
R7019:Ifi202b UTSW 1 173963958 missense probably benign 0.00
R7291:Ifi202b UTSW 1 173974815 missense probably benign 0.02
R7555:Ifi202b UTSW 1 173972221 missense probably damaging 0.99
R7825:Ifi202b UTSW 1 173975050 missense probably damaging 1.00
R8151:Ifi202b UTSW 1 173977357 missense probably benign 0.00
R8379:Ifi202b UTSW 1 173974732 critical splice donor site probably null
R8887:Ifi202b UTSW 1 173974914 missense probably damaging 1.00
R9177:Ifi202b UTSW 1 173977383 start codon destroyed probably null 0.01
Posted On 2015-04-16