Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02567:Ifi202b'

298856

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi202b

Ensembl Gene

ENSMUSG00000026535

Gene Name

interferon activated gene 202B

Synonyms

p202

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL02567

Quality Score

Status

Chromosome

Chromosomal Location

173962568-173982744 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 173963804 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 436 (S436N)

Ref Sequence

ENSEMBL: ENSMUSP00000000266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000266]

PDB Structure

Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000000266
AA Change: S436N

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: S436N

Domain	Start	End	E-Value	Type
Pfam:HIN	58	223	4.1e-68	PFAM
Pfam:HIN	256	421	1.5e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff4	C	A	11: 53,372,751	S199R	possibly damaging	Het
Ano1	A	G	7: 144,611,625	L621P	probably damaging	Het
Calcr	C	T	6: 3,691,564	V404M	probably damaging	Het
Carmil3	A	G	14: 55,498,882	S635G	possibly damaging	Het
Ccl12	C	A	11: 82,102,621	S28R	possibly damaging	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Cdhr3	T	C	12: 33,038,901	N761D	probably benign	Het
Col14a1	T	C	15: 55,344,961		probably null	Het
Col28a1	T	C	6: 8,014,819	K862R	possibly damaging	Het
Cyp2c66	C	T	19: 39,186,640		probably benign	Het
D5Ertd615e	T	C	5: 45,163,416		noncoding transcript	Het
Deup1	T	C	9: 15,575,283	E367G	probably damaging	Het
Dpp8	T	G	9: 65,078,776	Y849*	probably null	Het
Efhc1	T	A	1: 20,972,964	V369E	probably damaging	Het
Epg5	A	G	18: 78,033,073	Y2562C	probably damaging	Het
Fam189a1	T	A	7: 64,786,731	M101L	possibly damaging	Het
Fbln5	A	G	12: 101,761,800		probably null	Het
Frem1	A	T	4: 83,000,055	M551K	probably damaging	Het
Gba2	T	C	4: 43,567,281	S889G	probably benign	Het
Golph3	C	T	15: 12,349,421	R176*	probably null	Het
Got2	A	T	8: 95,872,201	F191Y	probably benign	Het
Gtf2ird2	G	T	5: 134,213,048		probably benign	Het
Hist4h4	G	A	6: 136,804,274	R36W	probably damaging	Het
Hivep3	A	G	4: 120,133,956	T2218A	probably damaging	Het
Htr1f	C	T	16: 64,926,248	G227D	probably benign	Het
Nf1	T	A	11: 79,547,143	V2109D	probably damaging	Het
Opa1	C	A	16: 29,588,286	D29E	probably benign	Het
Papln	C	T	12: 83,778,837	P631S	probably benign	Het
Pde4c	T	A	8: 70,747,921	M352K	probably benign	Het
Pigu	T	C	2: 155,331,192	T129A	possibly damaging	Het
Pla2g4c	T	A	7: 13,346,040	H424Q	probably damaging	Het
Ptpn13	T	G	5: 103,562,291	L1564R	probably damaging	Het
Rbm5	T	C	9: 107,744,274	D642G	probably damaging	Het
Rnf111	T	C	9: 70,459,005	T384A	probably damaging	Het
Scn11a	T	C	9: 119,804,489	T393A	probably damaging	Het
Sned1	A	T	1: 93,274,347	K619M	probably damaging	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Syt9	A	G	7: 107,436,661	Y295C	probably damaging	Het
Taar7f	T	A	10: 24,050,425	Y306N	probably damaging	Het
Tmem107	T	G	11: 69,071,019	L25V	possibly damaging	Het
Wdr24	T	G	17: 25,824,348	I48S	probably damaging	Het
Zc3hc1	T	C	6: 30,374,849	D231G	probably benign	Het
Zfp142	T	A	1: 74,578,147	S342C	possibly damaging	Het
Zfp142	T	G	1: 74,578,149	K341T	possibly damaging	Het
Zfp142	T	C	1: 74,578,150	K341E	possibly damaging	Het
Zfp804b	T	A	5: 6,769,989	I989L	probably benign	Het
Zfyve9	A	C	4: 108,674,523	V1095G	probably damaging	Het

Other mutations in Ifi202b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01551:Ifi202b	APN	1	173971362	missense	probably benign	0.00
IGL02019:Ifi202b	APN	1	173974984	missense	possibly damaging	0.95
IGL02466:Ifi202b	APN	1	173972309	missense	possibly damaging	0.71
IGL02508:Ifi202b	APN	1	173974772	missense	probably benign	0.18
IGL02644:Ifi202b	APN	1	173971714	missense	probably benign	0.00
R0282:Ifi202b	UTSW	1	173977360	missense	probably benign	0.00
R1178:Ifi202b	UTSW	1	173972222	missense	probably benign	0.02
R3414:Ifi202b	UTSW	1	173963913	missense	probably benign	0.19
R5739:Ifi202b	UTSW	1	173971352	critical splice donor site	probably null
R5944:Ifi202b	UTSW	1	173963799	missense	probably benign	0.00
R6805:Ifi202b	UTSW	1	173974989	missense	probably damaging	1.00
R7019:Ifi202b	UTSW	1	173963958	missense	probably benign	0.00
R7291:Ifi202b	UTSW	1	173974815	missense	probably benign	0.02
R7555:Ifi202b	UTSW	1	173972221	missense	probably damaging	0.99
R7825:Ifi202b	UTSW	1	173975050	missense	probably damaging	1.00
R8151:Ifi202b	UTSW	1	173977357	missense	probably benign	0.00
R8379:Ifi202b	UTSW	1	173974732	critical splice donor site	probably null

Posted On

2015-04-16