Incidental Mutation 'IGL02567:Ifi202b'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi202b
Ensembl Gene ENSMUSG00000026535
Gene Nameinterferon activated gene 202B
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL02567
Quality Score
Chromosomal Location173962568-173982744 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 173963804 bp
Amino Acid Change Serine to Asparagine at position 436 (S436N)
Ref Sequence ENSEMBL: ENSMUSP00000000266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000266]
PDB Structure
Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000000266
AA Change: S436N

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: S436N

Pfam:HIN 58 223 4.1e-68 PFAM
Pfam:HIN 256 421 1.5e-61 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 C A 11: 53,372,751 S199R possibly damaging Het
Ano1 A G 7: 144,611,625 L621P probably damaging Het
Calcr C T 6: 3,691,564 V404M probably damaging Het
Carmil3 A G 14: 55,498,882 S635G possibly damaging Het
Ccl12 C A 11: 82,102,621 S28R possibly damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cdhr3 T C 12: 33,038,901 N761D probably benign Het
Col14a1 T C 15: 55,344,961 probably null Het
Col28a1 T C 6: 8,014,819 K862R possibly damaging Het
Cyp2c66 C T 19: 39,186,640 probably benign Het
D5Ertd615e T C 5: 45,163,416 noncoding transcript Het
Deup1 T C 9: 15,575,283 E367G probably damaging Het
Dpp8 T G 9: 65,078,776 Y849* probably null Het
Efhc1 T A 1: 20,972,964 V369E probably damaging Het
Epg5 A G 18: 78,033,073 Y2562C probably damaging Het
Fam189a1 T A 7: 64,786,731 M101L possibly damaging Het
Fbln5 A G 12: 101,761,800 probably null Het
Frem1 A T 4: 83,000,055 M551K probably damaging Het
Gba2 T C 4: 43,567,281 S889G probably benign Het
Golph3 C T 15: 12,349,421 R176* probably null Het
Got2 A T 8: 95,872,201 F191Y probably benign Het
Gtf2ird2 G T 5: 134,213,048 probably benign Het
Hist4h4 G A 6: 136,804,274 R36W probably damaging Het
Hivep3 A G 4: 120,133,956 T2218A probably damaging Het
Htr1f C T 16: 64,926,248 G227D probably benign Het
Nf1 T A 11: 79,547,143 V2109D probably damaging Het
Opa1 C A 16: 29,588,286 D29E probably benign Het
Papln C T 12: 83,778,837 P631S probably benign Het
Pde4c T A 8: 70,747,921 M352K probably benign Het
Pigu T C 2: 155,331,192 T129A possibly damaging Het
Pla2g4c T A 7: 13,346,040 H424Q probably damaging Het
Ptpn13 T G 5: 103,562,291 L1564R probably damaging Het
Rbm5 T C 9: 107,744,274 D642G probably damaging Het
Rnf111 T C 9: 70,459,005 T384A probably damaging Het
Scn11a T C 9: 119,804,489 T393A probably damaging Het
Sned1 A T 1: 93,274,347 K619M probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Syt9 A G 7: 107,436,661 Y295C probably damaging Het
Taar7f T A 10: 24,050,425 Y306N probably damaging Het
Tmem107 T G 11: 69,071,019 L25V possibly damaging Het
Wdr24 T G 17: 25,824,348 I48S probably damaging Het
Zc3hc1 T C 6: 30,374,849 D231G probably benign Het
Zfp142 T A 1: 74,578,147 S342C possibly damaging Het
Zfp142 T G 1: 74,578,149 K341T possibly damaging Het
Zfp142 T C 1: 74,578,150 K341E possibly damaging Het
Zfp804b T A 5: 6,769,989 I989L probably benign Het
Zfyve9 A C 4: 108,674,523 V1095G probably damaging Het
Other mutations in Ifi202b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Ifi202b APN 1 173971362 missense probably benign 0.00
IGL02019:Ifi202b APN 1 173974984 missense possibly damaging 0.95
IGL02466:Ifi202b APN 1 173972309 missense possibly damaging 0.71
IGL02508:Ifi202b APN 1 173974772 missense probably benign 0.18
IGL02644:Ifi202b APN 1 173971714 missense probably benign 0.00
R0282:Ifi202b UTSW 1 173977360 missense probably benign 0.00
R1178:Ifi202b UTSW 1 173972222 missense probably benign 0.02
R3414:Ifi202b UTSW 1 173963913 missense probably benign 0.19
R5739:Ifi202b UTSW 1 173971352 critical splice donor site probably null
R5944:Ifi202b UTSW 1 173963799 missense probably benign 0.00
R6805:Ifi202b UTSW 1 173974989 missense probably damaging 1.00
R7019:Ifi202b UTSW 1 173963958 missense probably benign 0.00
R7291:Ifi202b UTSW 1 173974815 missense probably benign 0.02
R7555:Ifi202b UTSW 1 173972221 missense probably damaging 0.99
R7825:Ifi202b UTSW 1 173975050 missense probably damaging 1.00
R8151:Ifi202b UTSW 1 173977357 missense probably benign 0.00
R8379:Ifi202b UTSW 1 173974732 critical splice donor site probably null
Posted On2015-04-16