Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02644:Ifi202b'

301854

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi202b

Ensembl Gene

ENSMUSG00000026535

Gene Name

interferon activated gene 202B

Synonyms

p202

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02644

Quality Score

Status

Chromosome

Chromosomal Location

173790134-173810310 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 173799280 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 256 (H256L)

Ref Sequence

ENSEMBL: ENSMUSP00000000266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000266]

AlphaFold

Q9R002

PDB Structure

Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000000266
AA Change: H256L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: H256L

Domain	Start	End	E-Value	Type
Pfam:HIN	58	223	4.1e-68	PFAM
Pfam:HIN	256	421	1.5e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	A	T	3: 151,198,007 (GRCm39)	Y89F	probably benign	Het
Agl	A	G	3: 116,580,246 (GRCm39)	Y406H	probably damaging	Het
Ankhd1	G	A	18: 36,711,828 (GRCm39)		probably null	Het
Ankmy1	T	C	1: 92,812,776 (GRCm39)	D511G	probably benign	Het
Arid2	T	C	15: 96,266,589 (GRCm39)	Y546H	probably damaging	Het
Asap1	G	T	15: 63,982,911 (GRCm39)	P806T	probably damaging	Het
Aspa	T	A	11: 73,212,992 (GRCm39)	T117S	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bspry	A	T	4: 62,414,565 (GRCm39)	H386L	probably damaging	Het
C1qc	T	C	4: 136,617,629 (GRCm39)	T156A	possibly damaging	Het
Cfhr4	A	G	1: 139,708,905 (GRCm39)	M1T	probably null	Het
Copz2	A	T	11: 96,744,257 (GRCm39)		probably benign	Het
Cybb	A	G	X: 9,333,395 (GRCm39)	V23A	probably benign	Het
D630003M21Rik	T	A	2: 158,058,730 (GRCm39)	D390V	possibly damaging	Het
Dennd10	T	A	19: 60,810,741 (GRCm39)	S43T	possibly damaging	Het
Dpy19l2	G	T	9: 24,569,888 (GRCm39)	P355Q	probably damaging	Het
Gcn1	A	T	5: 115,713,250 (GRCm39)	Q71L	probably benign	Het
Gpd1l	T	C	9: 114,732,725 (GRCm39)		probably null	Het
Hydin	A	G	8: 111,265,100 (GRCm39)	D2761G	probably damaging	Het
Igkv8-24	T	C	6: 70,193,872 (GRCm39)	Y112C	probably damaging	Het
Lama3	G	A	18: 12,658,910 (GRCm39)	R2022Q	probably benign	Het
Mroh4	T	A	15: 74,482,224 (GRCm39)	R675S	possibly damaging	Het
Mtf1	T	G	4: 124,714,028 (GRCm39)	C146G	probably damaging	Het
Nubpl	A	G	12: 52,317,841 (GRCm39)	D178G	probably damaging	Het
Or7e165	A	C	9: 19,695,010 (GRCm39)	I194L	probably benign	Het
Pam16	A	G	16: 4,434,697 (GRCm39)	S91P	probably damaging	Het
Pcdhac2	A	G	18: 37,278,232 (GRCm39)	E404G	probably benign	Het
Pde7a	C	A	3: 19,311,031 (GRCm39)		probably benign	Het
Perm1	G	T	4: 156,303,043 (GRCm39)	G529V	probably damaging	Het
Pik3c2a	T	C	7: 115,972,049 (GRCm39)	T794A	probably benign	Het
Ppfibp1	A	G	6: 146,923,938 (GRCm39)	Y722C	probably damaging	Het
Ppm1m	A	T	9: 106,074,082 (GRCm39)	I241N	probably damaging	Het
Psd	T	C	19: 46,311,834 (GRCm39)	Y282C	probably damaging	Het
Rpl27	T	A	11: 101,336,317 (GRCm39)		probably benign	Het
Scaf1	A	G	7: 44,655,357 (GRCm39)		probably benign	Het
Sec14l2	A	T	11: 4,053,380 (GRCm39)		probably benign	Het
Smchd1	T	A	17: 71,667,016 (GRCm39)		probably benign	Het
Sptb	A	T	12: 76,652,391 (GRCm39)	D1615E	probably damaging	Het
Stt3a	A	C	9: 36,663,649 (GRCm39)	C198G	possibly damaging	Het
Tas2r144	T	C	6: 42,192,787 (GRCm39)	S176P	possibly damaging	Het
Tlr13	A	G	X: 105,200,503 (GRCm39)	D80G	probably benign	Het
Tmco4	A	G	4: 138,737,920 (GRCm39)		probably benign	Het
Tnpo2	T	A	8: 85,771,109 (GRCm39)	C132S	possibly damaging	Het
Tubgcp3	T	C	8: 12,698,733 (GRCm39)	D406G	probably damaging	Het
Vmn2r125	G	A	4: 156,703,294 (GRCm39)	R224Q	probably benign	Het
Zfp524	C	A	7: 5,020,479 (GRCm39)	D2E	probably damaging	Het

Other mutations in Ifi202b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01551:Ifi202b	APN	1	173,798,928 (GRCm39)	missense	probably benign	0.00
IGL02019:Ifi202b	APN	1	173,802,550 (GRCm39)	missense	possibly damaging	0.95
IGL02466:Ifi202b	APN	1	173,799,875 (GRCm39)	missense	possibly damaging	0.71
IGL02508:Ifi202b	APN	1	173,802,338 (GRCm39)	missense	probably benign	0.18
IGL02567:Ifi202b	APN	1	173,791,370 (GRCm39)	missense	possibly damaging	0.84
R0282:Ifi202b	UTSW	1	173,804,926 (GRCm39)	missense	probably benign	0.00
R1178:Ifi202b	UTSW	1	173,799,788 (GRCm39)	missense	probably benign	0.02
R3414:Ifi202b	UTSW	1	173,791,479 (GRCm39)	missense	probably benign	0.19
R5739:Ifi202b	UTSW	1	173,798,918 (GRCm39)	critical splice donor site	probably null
R5944:Ifi202b	UTSW	1	173,791,365 (GRCm39)	missense	probably benign	0.00
R6805:Ifi202b	UTSW	1	173,802,555 (GRCm39)	missense	probably damaging	1.00
R7019:Ifi202b	UTSW	1	173,791,524 (GRCm39)	missense	probably benign	0.00
R7291:Ifi202b	UTSW	1	173,802,381 (GRCm39)	missense	probably benign	0.02
R7555:Ifi202b	UTSW	1	173,799,787 (GRCm39)	missense	probably damaging	0.99
R7825:Ifi202b	UTSW	1	173,802,616 (GRCm39)	missense	probably damaging	1.00
R8151:Ifi202b	UTSW	1	173,804,923 (GRCm39)	missense	probably benign	0.00
R8379:Ifi202b	UTSW	1	173,802,298 (GRCm39)	critical splice donor site	probably null
R8887:Ifi202b	UTSW	1	173,802,480 (GRCm39)	missense	probably damaging	1.00
R9177:Ifi202b	UTSW	1	173,804,949 (GRCm39)	start codon destroyed	probably null	0.01
R9642:Ifi202b	UTSW	1	173,799,850 (GRCm39)	nonsense	probably null

Posted On

2015-04-16