Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02567:Cyp2c66'

298886

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c66

Ensembl Gene

ENSMUSG00000067229

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 66

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.193) question?

Stock #

IGL02567

Quality Score

Status

Chromosome

Chromosomal Location

39113898-39187072 bp(+) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

C to T at 39186640 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000120397 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087234] [ENSMUST00000146494]

AlphaFold

Q5GLZ0

Predicted Effect

probably benign
Transcript: ENSMUST00000087234

SMART Domains

Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	1e-157	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000146494

SMART Domains

Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
SCOP:d1cpt__	26	55	4e-9	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aff4	C	A	11: 53,372,751	S199R	possibly damaging	Het
Ano1	A	G	7: 144,611,625	L621P	probably damaging	Het
Calcr	C	T	6: 3,691,564	V404M	probably damaging	Het
Carmil3	A	G	14: 55,498,882	S635G	possibly damaging	Het
Ccl12	C	A	11: 82,102,621	S28R	possibly damaging	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Cdhr3	T	C	12: 33,038,901	N761D	probably benign	Het
Col14a1	T	C	15: 55,344,961		probably null	Het
Col28a1	T	C	6: 8,014,819	K862R	possibly damaging	Het
D5Ertd615e	T	C	5: 45,163,416		noncoding transcript	Het
Deup1	T	C	9: 15,575,283	E367G	probably damaging	Het
Dpp8	T	G	9: 65,078,776	Y849*	probably null	Het
Efhc1	T	A	1: 20,972,964	V369E	probably damaging	Het
Epg5	A	G	18: 78,033,073	Y2562C	probably damaging	Het
Fam189a1	T	A	7: 64,786,731	M101L	possibly damaging	Het
Fbln5	A	G	12: 101,761,800		probably null	Het
Frem1	A	T	4: 83,000,055	M551K	probably damaging	Het
Gba2	T	C	4: 43,567,281	S889G	probably benign	Het
Golph3	C	T	15: 12,349,421	R176*	probably null	Het
Got2	A	T	8: 95,872,201	F191Y	probably benign	Het
Gtf2ird2	G	T	5: 134,213,048		probably benign	Het
Hist4h4	G	A	6: 136,804,274	R36W	probably damaging	Het
Hivep3	A	G	4: 120,133,956	T2218A	probably damaging	Het
Htr1f	C	T	16: 64,926,248	G227D	probably benign	Het
Ifi202b	C	T	1: 173,963,804	S436N	possibly damaging	Het
Nf1	T	A	11: 79,547,143	V2109D	probably damaging	Het
Opa1	C	A	16: 29,588,286	D29E	probably benign	Het
Papln	C	T	12: 83,778,837	P631S	probably benign	Het
Pde4c	T	A	8: 70,747,921	M352K	probably benign	Het
Pigu	T	C	2: 155,331,192	T129A	possibly damaging	Het
Pla2g4c	T	A	7: 13,346,040	H424Q	probably damaging	Het
Ptpn13	T	G	5: 103,562,291	L1564R	probably damaging	Het
Rbm5	T	C	9: 107,744,274	D642G	probably damaging	Het
Rnf111	T	C	9: 70,459,005	T384A	probably damaging	Het
Scn11a	T	C	9: 119,804,489	T393A	probably damaging	Het
Sned1	A	T	1: 93,274,347	K619M	probably damaging	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Syt9	A	G	7: 107,436,661	Y295C	probably damaging	Het
Taar7f	T	A	10: 24,050,425	Y306N	probably damaging	Het
Tmem107	T	G	11: 69,071,019	L25V	possibly damaging	Het
Wdr24	T	G	17: 25,824,348	I48S	probably damaging	Het
Zc3hc1	T	C	6: 30,374,849	D231G	probably benign	Het
Zfp142	T	A	1: 74,578,147	S342C	possibly damaging	Het
Zfp142	T	G	1: 74,578,149	K341T	possibly damaging	Het
Zfp142	T	C	1: 74,578,150	K341E	possibly damaging	Het
Zfp804b	T	A	5: 6,769,989	I989L	probably benign	Het
Zfyve9	A	C	4: 108,674,523	V1095G	probably damaging	Het

Other mutations in Cyp2c66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01145:Cyp2c66	APN	19	39170961	missense	probably benign	0.00
IGL01589:Cyp2c66	APN	19	39183935	critical splice donor site	probably null
IGL02098:Cyp2c66	APN	19	39171029	missense	probably damaging	1.00
IGL02114:Cyp2c66	APN	19	39171075	splice site	probably benign
IGL03181:Cyp2c66	APN	19	39142039	missense	probably benign	0.00
IGL03230:Cyp2c66	APN	19	39183858	missense	possibly damaging	0.91
R0007:Cyp2c66	UTSW	19	39170958	nonsense	probably null
R0092:Cyp2c66	UTSW	19	39183780	splice site	probably benign
R0242:Cyp2c66	UTSW	19	39141925	missense	probably damaging	1.00
R0242:Cyp2c66	UTSW	19	39141925	missense	probably damaging	1.00
R0324:Cyp2c66	UTSW	19	39176691	missense	probably benign	0.27
R0675:Cyp2c66	UTSW	19	39186616	missense	possibly damaging	0.93
R1127:Cyp2c66	UTSW	19	39163368	missense	probably damaging	1.00
R1871:Cyp2c66	UTSW	19	39163414	missense	possibly damaging	0.66
R3404:Cyp2c66	UTSW	19	39163327	missense	probably benign
R3429:Cyp2c66	UTSW	19	39163448	missense	probably damaging	0.97
R3896:Cyp2c66	UTSW	19	39142278	missense	possibly damaging	0.82
R4115:Cyp2c66	UTSW	19	39176559	missense	possibly damaging	0.66
R4116:Cyp2c66	UTSW	19	39176559	missense	possibly damaging	0.66
R4667:Cyp2c66	UTSW	19	39176656	missense	probably damaging	1.00
R4668:Cyp2c66	UTSW	19	39176656	missense	probably damaging	1.00
R4711:Cyp2c66	UTSW	19	39163399	missense	possibly damaging	0.74
R4960:Cyp2c66	UTSW	19	39163322	critical splice acceptor site	probably null
R5070:Cyp2c66	UTSW	19	39163470	missense	probably benign	0.15
R5113:Cyp2c66	UTSW	19	39163438	missense	probably benign	0.00
R5125:Cyp2c66	UTSW	19	39171029	missense	probably damaging	1.00
R5178:Cyp2c66	UTSW	19	39171029	missense	probably damaging	1.00
R5588:Cyp2c66	UTSW	19	39163414	missense	possibly damaging	0.66
R6011:Cyp2c66	UTSW	19	39141936	missense	probably benign	0.00
R6497:Cyp2c66	UTSW	19	39163377	missense	probably damaging	0.96
R6707:Cyp2c66	UTSW	19	39186500	missense	probably damaging	1.00
R7173:Cyp2c66	UTSW	19	39170957	missense	probably benign	0.01
R7202:Cyp2c66	UTSW	19	39141904	missense	probably damaging	1.00
R7469:Cyp2c66	UTSW	19	39183863	missense	probably damaging	1.00
R7614:Cyp2c66	UTSW	19	39171028	missense	probably damaging	0.98
R7985:Cyp2c66	UTSW	19	39113986	missense	probably null	1.00
R8012:Cyp2c66	UTSW	19	39183925	missense	probably damaging	1.00
R8056:Cyp2c66	UTSW	19	39142041	missense	probably benign	0.00
R8302:Cyp2c66	UTSW	19	39176634	missense	probably damaging	1.00
R8329:Cyp2c66	UTSW	19	39186462	nonsense	probably null
R8365:Cyp2c66	UTSW	19	39176604	missense	probably benign	0.00
R8472:Cyp2c66	UTSW	19	39176577	missense	probably benign	0.03
R8502:Cyp2c66	UTSW	19	39142329	missense	probably benign	0.01
R8688:Cyp2c66	UTSW	19	39163440	missense	probably benign	0.00
R8715:Cyp2c66	UTSW	19	39170944	missense	probably benign	0.01
R9199:Cyp2c66	UTSW	19	39142356	missense	probably benign	0.16
R9551:Cyp2c66	UTSW	19	39183802	missense	probably damaging	0.99
R9552:Cyp2c66	UTSW	19	39183802	missense	probably damaging	0.99
R9601:Cyp2c66	UTSW	19	39186610	missense	probably benign
R9777:Cyp2c66	UTSW	19	39114076	missense	probably benign	0.15
Z1177:Cyp2c66	UTSW	19	39186626	missense	probably damaging	0.96

Posted On

2015-04-16