Incidental Mutation 'IGL02836:Oosp3'
ID361656
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp3
Ensembl Gene ENSMUSG00000055933
Gene Nameoocyte secreted protein 3
SynonymsLOC225923, Gm97
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.312) question?
Stock #IGL02836
Quality Score
Status
Chromosome19
Chromosomal Location11697055-11711874 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 11700968 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 5 (I5V)
Ref Sequence ENSEMBL: ENSMUSP00000112874 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069760] [ENSMUST00000119053]
Predicted Effect probably benign
Transcript: ENSMUST00000069760
AA Change: I103V

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000064913
Gene: ENSMUSG00000055933
AA Change: I103V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
PDB:3EF7|B 25 118 1e-5 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000119053
AA Change: I5V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190477
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 T A 4: 144,623,212 N346K possibly damaging Het
Abca15 A G 7: 120,388,216 M1242V probably benign Het
Abca6 T A 11: 110,248,548 E33D probably damaging Het
Abca8a T C 11: 110,070,351 K582E possibly damaging Het
Abcb6 A G 1: 75,178,002 L263P probably damaging Het
Adamts2 A C 11: 50,787,279 E795A probably damaging Het
Avil T A 10: 127,008,995 I292N probably damaging Het
Ccdc129 T A 6: 55,898,090 W342R probably damaging Het
Cd300ld2 T C 11: 115,013,750 D97G probably benign Het
Cfh A C 1: 140,102,399 I912R probably damaging Het
Cyp26c1 A T 19: 37,687,156 Q156L probably benign Het
Dhx57 T C 17: 80,267,549 I614V probably damaging Het
Dip2c T A 13: 9,610,790 S896T probably damaging Het
Dmtn G T 14: 70,616,078 P97Q probably damaging Het
Dock6 A T 9: 21,801,864 V1931E probably damaging Het
Dpep2 C A 8: 105,990,595 probably null Het
Dsg1c T A 18: 20,267,929 L163Q probably benign Het
Esyt3 A G 9: 99,320,907 probably benign Het
Fcgbp T A 7: 28,117,358 I2415N possibly damaging Het
Fpr-rs6 T C 17: 20,183,045 D18G probably benign Het
Fras1 T C 5: 96,534,866 V74A possibly damaging Het
Frem3 T C 8: 80,614,381 V1101A probably benign Het
Fut8 T A 12: 77,450,213 V399E probably benign Het
Galntl5 G T 5: 25,186,239 K45N probably benign Het
Gbe1 A G 16: 70,561,095 Y669C possibly damaging Het
Gcnt1 T C 19: 17,330,129 I77M probably benign Het
Mark2 A G 19: 7,278,040 probably null Het
Muc2 A T 7: 141,746,713 probably benign Het
Nacc2 C T 2: 26,090,317 V36I probably damaging Het
Nphp1 T C 2: 127,769,623 I268V probably benign Het
Olfr1154 T G 2: 87,903,380 T99P possibly damaging Het
Pex7 A G 10: 19,894,244 probably benign Het
Prr14l T C 5: 32,831,096 K352E probably benign Het
Rheb T A 5: 24,803,711 I170F probably benign Het
Rpgrip1 A G 14: 52,145,257 probably null Het
Rps2 T A 17: 24,720,676 L107Q probably damaging Het
Rrp1 A T 10: 78,405,040 probably benign Het
Rtcb A T 10: 85,943,942 V288D possibly damaging Het
Sec14l3 T C 11: 4,070,084 F174L probably benign Het
Slc28a1 G A 7: 81,126,161 V202M probably damaging Het
Slc44a3 A T 3: 121,531,717 C32S probably damaging Het
Syne1 G A 10: 5,409,875 probably benign Het
Synrg C A 11: 84,001,978 probably benign Het
Tmem219 A T 7: 126,888,949 F265I probably benign Het
Tmem94 T C 11: 115,792,939 I726T probably damaging Het
Trim37 T C 11: 87,196,959 M632T probably benign Het
Trpm6 A T 19: 18,813,482 Q627L probably damaging Het
Uvrag A G 7: 98,979,777 V361A possibly damaging Het
Yipf3 C A 17: 46,251,594 N308K possibly damaging Het
Zfp438 A G 18: 5,245,427 probably benign Het
Zmiz1 T A 14: 25,656,742 probably benign Het
Zranb3 A G 1: 127,960,825 V841A probably benign Het
Other mutations in Oosp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00861:Oosp3 APN 19 11711640 missense probably benign 0.03
IGL01959:Oosp3 APN 19 11700922 missense probably benign 0.00
IGL02006:Oosp3 APN 19 11699420 missense probably damaging 0.99
IGL02231:Oosp3 APN 19 11699439 missense probably damaging 0.99
R1669:Oosp3 UTSW 19 11701014 splice site probably benign
R2045:Oosp3 UTSW 19 11699369 missense probably benign 0.03
R2852:Oosp3 UTSW 19 11699532 critical splice donor site probably null
R4820:Oosp3 UTSW 19 11711633 missense probably damaging 0.97
R5030:Oosp3 UTSW 19 11700944 missense probably benign 0.02
R5524:Oosp3 UTSW 19 11705430 missense possibly damaging 0.66
R5641:Oosp3 UTSW 19 11697173 critical splice donor site probably null
R5933:Oosp3 UTSW 19 11705389 missense probably benign 0.07
R7018:Oosp3 UTSW 19 11699419 missense probably benign 0.00
R7585:Oosp3 UTSW 19 11700958 missense probably benign 0.00
Posted On2015-12-18