Incidental Mutation 'IGL02932:Or2w6'
ID 364136
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2w6
Ensembl Gene ENSMUSG00000049737
Gene Name olfactory receptor family 2 subfamily W member 6
Synonyms GA_x6K02T2QHY8-11577590-11578528, MOR256-12, Olfr1361
Accession Numbers
Essential gene? Probably non essential (E-score: 0.179) question?
Stock # IGL02932
Quality Score
Status
Chromosome 13
Chromosomal Location 21842538-21848693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21843001 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 164 (M164K)
Ref Sequence ENSEMBL: ENSMUSP00000150315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055615] [ENSMUST00000214321]
AlphaFold Q8VFH0
Predicted Effect probably damaging
Transcript: ENSMUST00000055615
AA Change: M164K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000062356
Gene: ENSMUSG00000049737
AA Change: M164K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 30 312 4.2e-10 PFAM
Pfam:7tm_4 36 313 7.7e-52 PFAM
Pfam:7tm_1 46 295 1.5e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214321
AA Change: M164K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,709 (GRCm39) E122D probably damaging Het
Asb3 G A 11: 30,979,067 (GRCm39) probably null Het
Avl9 T C 6: 56,713,536 (GRCm39) S265P probably benign Het
Cep44 C T 8: 57,000,459 (GRCm39) R18Q probably damaging Het
Clec10a T C 11: 70,060,554 (GRCm39) probably benign Het
Cog4 A G 8: 111,579,065 (GRCm39) I115V probably benign Het
Coq3 C T 4: 21,900,430 (GRCm39) A219V probably benign Het
Cry2 G A 2: 92,243,462 (GRCm39) R460* probably null Het
Ddx39b A G 17: 35,472,337 (GRCm39) probably benign Het
Dhx40 G A 11: 86,662,755 (GRCm39) R646C probably damaging Het
Ears2 G A 7: 121,662,284 (GRCm39) R55C probably damaging Het
Eif3m C T 2: 104,845,214 (GRCm39) G26R probably damaging Het
Exo5 A G 4: 120,779,742 (GRCm39) L41P probably benign Het
Fut10 A G 8: 31,749,965 (GRCm39) H417R probably damaging Het
Gars1 T A 6: 55,037,929 (GRCm39) L296Q probably damaging Het
Gpr143 A T X: 151,576,439 (GRCm39) probably benign Het
Htr1b C A 9: 81,513,689 (GRCm39) R306L probably damaging Het
Lama3 G A 18: 12,661,858 (GRCm39) A2185T probably damaging Het
Mbd5 C A 2: 49,169,460 (GRCm39) Q1544K possibly damaging Het
Mccc1 T C 3: 36,014,178 (GRCm39) E713G possibly damaging Het
Mttp A G 3: 137,817,505 (GRCm39) F415S probably benign Het
Mug1 A G 6: 121,864,386 (GRCm39) T1428A probably benign Het
Mup6 A C 4: 60,006,009 (GRCm39) D159A probably damaging Het
Nsd2 T C 5: 34,037,472 (GRCm39) L698P probably damaging Het
Or4p22 G T 2: 88,317,519 (GRCm39) V148F probably benign Het
Or5p70 A G 7: 107,994,720 (GRCm39) N131S probably benign Het
Or6c217 A T 10: 129,738,287 (GRCm39) C97* probably null Het
Osgepl1 G A 1: 53,360,675 (GRCm39) R372H probably benign Het
Pias2 C T 18: 77,232,799 (GRCm39) H537Y probably damaging Het
Slc38a7 A C 8: 96,572,783 (GRCm39) I149M probably damaging Het
Smn1 A G 13: 100,264,472 (GRCm39) T68A probably benign Het
Syde2 A G 3: 145,707,231 (GRCm39) K657R possibly damaging Het
Tdrd5 A T 1: 156,098,190 (GRCm39) H625Q possibly damaging Het
Tead3 T C 17: 28,560,325 (GRCm39) Y2C probably damaging Het
Tmem255a T A X: 37,296,940 (GRCm39) T280S probably benign Het
Ttpa A G 4: 20,021,215 (GRCm39) T128A possibly damaging Het
Wdhd1 A G 14: 47,509,591 (GRCm39) probably null Het
Other mutations in Or2w6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Or2w6 APN 13 21,842,953 (GRCm39) missense possibly damaging 0.63
IGL02025:Or2w6 APN 13 21,843,433 (GRCm39) missense possibly damaging 0.92
IGL02275:Or2w6 APN 13 21,843,170 (GRCm39) missense probably benign 0.01
IGL02831:Or2w6 APN 13 21,843,074 (GRCm39) missense probably benign
R0102:Or2w6 UTSW 13 21,842,905 (GRCm39) missense probably damaging 1.00
R0597:Or2w6 UTSW 13 21,843,316 (GRCm39) missense probably damaging 0.96
R1669:Or2w6 UTSW 13 21,843,456 (GRCm39) missense possibly damaging 0.91
R2006:Or2w6 UTSW 13 21,842,642 (GRCm39) missense possibly damaging 0.94
R2292:Or2w6 UTSW 13 21,843,001 (GRCm39) missense probably damaging 1.00
R4894:Or2w6 UTSW 13 21,843,352 (GRCm39) missense probably damaging 1.00
R4919:Or2w6 UTSW 13 21,842,794 (GRCm39) missense possibly damaging 0.59
R5339:Or2w6 UTSW 13 21,843,404 (GRCm39) missense probably benign 0.37
R5815:Or2w6 UTSW 13 21,842,707 (GRCm39) missense probably damaging 1.00
R6248:Or2w6 UTSW 13 21,843,244 (GRCm39) missense possibly damaging 0.72
R8273:Or2w6 UTSW 13 21,843,377 (GRCm39) missense probably damaging 1.00
R8323:Or2w6 UTSW 13 21,843,302 (GRCm39) missense possibly damaging 0.95
R8913:Or2w6 UTSW 13 21,843,274 (GRCm39) missense probably damaging 1.00
R9010:Or2w6 UTSW 13 21,842,681 (GRCm39) missense probably damaging 0.99
Posted On 2015-12-18