Incidental Mutation 'IGL02932:Clec10a'
ID364164
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clec10a
Ensembl Gene ENSMUSG00000000318
Gene NameC-type lectin domain family 10, member A
SynonymsCD301a, Mgl1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02932
Quality Score
Status
Chromosome11
Chromosomal Location70156197-70170834 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 70169728 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137447 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000327] [ENSMUST00000102571] [ENSMUST00000144935] [ENSMUST00000152635] [ENSMUST00000153959] [ENSMUST00000178567] [ENSMUST00000178945]
Predicted Effect probably benign
Transcript: ENSMUST00000000327
SMART Domains Protein: ENSMUSP00000000327
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 1 164 8.5e-64 PFAM
CLECT 174 298 1.24e-38 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102571
SMART Domains Protein: ENSMUSP00000099631
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 1 163 3.9e-65 PFAM
CLECT 173 297 1.24e-38 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143298
Predicted Effect probably benign
Transcript: ENSMUST00000144935
SMART Domains Protein: ENSMUSP00000136500
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 19 126 2e-35 PFAM
CLECT 136 212 1.16e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150966
Predicted Effect probably benign
Transcript: ENSMUST00000152635
Predicted Effect probably benign
Transcript: ENSMUST00000153959
SMART Domains Protein: ENSMUSP00000117772
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 1 41 6e-19 PFAM
Pfam:Lectin_C 68 102 2.3e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178567
SMART Domains Protein: ENSMUSP00000136322
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 1 57 1.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178945
SMART Domains Protein: ENSMUSP00000137447
Gene: ENSMUSG00000000318

DomainStartEndE-ValueType
Pfam:Lectin_N 7 164 3.6e-51 PFAM
CLECT 174 292 1e-24 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180106
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation exhibit elevated red blood cell counts but appear to be otherwise normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,708 E122D probably damaging Het
Asb3 G A 11: 31,029,067 probably null Het
Avl9 T C 6: 56,736,551 S265P probably benign Het
Cep44 C T 8: 56,547,424 R18Q probably damaging Het
Cog4 A G 8: 110,852,433 I115V probably benign Het
Coq3 C T 4: 21,900,430 A219V probably benign Het
Cry2 G A 2: 92,413,117 R460* probably null Het
Ddx39b A G 17: 35,253,361 probably benign Het
Dhx40 G A 11: 86,771,929 R646C probably damaging Het
Ears2 G A 7: 122,063,061 R55C probably damaging Het
Eif3m C T 2: 105,014,869 G26R probably damaging Het
Exo5 A G 4: 120,922,545 L41P probably benign Het
Fut10 A G 8: 31,259,937 H417R probably damaging Het
Gars T A 6: 55,060,944 L296Q probably damaging Het
Gpr143 A T X: 152,793,443 probably benign Het
Htr1b C A 9: 81,631,636 R306L probably damaging Het
Lama3 G A 18: 12,528,801 A2185T probably damaging Het
Mbd5 C A 2: 49,279,448 Q1544K possibly damaging Het
Mccc1 T C 3: 35,960,029 E713G possibly damaging Het
Mttp A G 3: 138,111,744 F415S probably benign Het
Mug1 A G 6: 121,887,427 T1428A probably benign Het
Mup6 A C 4: 60,006,009 D159A probably damaging Het
Nsd2 T C 5: 33,880,128 L698P probably damaging Het
Olfr1184 G T 2: 88,487,175 V148F probably benign Het
Olfr1361 A T 13: 21,658,831 M164K probably damaging Het
Olfr495 A G 7: 108,395,513 N131S probably benign Het
Olfr815 A T 10: 129,902,418 C97* probably null Het
Osgepl1 G A 1: 53,321,516 R372H probably benign Het
Pias2 C T 18: 77,145,103 H537Y probably damaging Het
Slc38a7 A C 8: 95,846,155 I149M probably damaging Het
Smn1 A G 13: 100,127,964 T68A probably benign Het
Syde2 A G 3: 146,001,476 K657R possibly damaging Het
Tdrd5 A T 1: 156,270,620 H625Q possibly damaging Het
Tead3 T C 17: 28,341,351 Y2C probably damaging Het
Tmem255a T A X: 38,208,063 T280S probably benign Het
Ttpa A G 4: 20,021,215 T128A possibly damaging Het
Wdhd1 A G 14: 47,272,134 probably null Het
Other mutations in Clec10a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02945:Clec10a APN 11 70170542 missense possibly damaging 0.94
R1264:Clec10a UTSW 11 70169741 missense possibly damaging 0.95
R1539:Clec10a UTSW 11 70169819 missense probably damaging 1.00
R2113:Clec10a UTSW 11 70169824 critical splice donor site probably null
R2567:Clec10a UTSW 11 70169532 critical splice donor site probably null
R4597:Clec10a UTSW 11 70169980 missense probably damaging 1.00
R4907:Clec10a UTSW 11 70169971 missense probably benign 0.25
R4913:Clec10a UTSW 11 70170025 missense probably damaging 1.00
R6577:Clec10a UTSW 11 70170610 missense probably benign 0.08
R7538:Clec10a UTSW 11 70169778 missense probably benign 0.39
R8184:Clec10a UTSW 11 70169816 missense probably damaging 0.99
Posted On2015-12-18