Incidental Mutation 'IGL02967:Ncoa1'
ID 365651
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ncoa1
Ensembl Gene ENSMUSG00000020647
Gene Name nuclear receptor coactivator 1
Synonyms KAT13A, steroid receptor coactivator-1, SRC-a/NCoA-1, SRC1, SRC-1, bHLHe74
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02967
Quality Score
Status
Chromosome 12
Chromosomal Location 4297362-4527182 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 4345294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 684 (H684Q)
Ref Sequence ENSEMBL: ENSMUSP00000151358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085814] [ENSMUST00000217674] [ENSMUST00000217794] [ENSMUST00000219275] [ENSMUST00000220434]
AlphaFold P70365
Predicted Effect probably damaging
Transcript: ENSMUST00000085814
AA Change: H684Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000082971
Gene: ENSMUSG00000020647
AA Change: H684Q

DomainStartEndE-ValueType
HLH 29 86 1.73e-9 SMART
PAS 111 178 1.32e-10 SMART
Pfam:PAS_11 259 370 8e-37 PFAM
low complexity region 419 441 N/A INTRINSIC
Pfam:NCOA_u2 468 591 1.3e-29 PFAM
Pfam:SRC-1 632 712 3.5e-26 PFAM
low complexity region 724 736 N/A INTRINSIC
PDB:3RVF|B 747 767 1e-6 PDB
low complexity region 777 785 N/A INTRINSIC
low complexity region 869 880 N/A INTRINSIC
Pfam:Nuc_rec_co-act 930 977 2.3e-23 PFAM
low complexity region 1059 1080 N/A INTRINSIC
low complexity region 1125 1137 N/A INTRINSIC
DUF1518 1155 1211 7.47e-16 SMART
DUF1518 1218 1274 1.14e-11 SMART
low complexity region 1303 1315 N/A INTRINSIC
low complexity region 1333 1354 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000217674
AA Change: H573Q

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217794
AA Change: H684Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000219275
Predicted Effect probably damaging
Transcript: ENSMUST00000220434
AA Change: H684Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show osteopenia, increased serum sex hormone levels, altered bone remodeling and skeletal responses to sex hormones, and obesity. Homozygotes for another null allele show thyroid and steroid hormone resistance, delayed Purkinje cell development, and behavioral deficits. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,328,291 (GRCm39) T3455A probably damaging Het
Abca8a G A 11: 109,941,762 (GRCm39) P1169L probably damaging Het
Ablim3 T A 18: 61,959,574 (GRCm39) K272* probably null Het
Abtb3 A G 10: 85,469,646 (GRCm39) T856A probably benign Het
Acin1 A G 14: 54,880,210 (GRCm39) V574A possibly damaging Het
Acot4 A T 12: 84,090,235 (GRCm39) I311L probably benign Het
Akap9 C T 5: 4,026,164 (GRCm39) A1273V probably benign Het
Ap1g2 T A 14: 55,342,479 (GRCm39) probably benign Het
Apob A T 12: 8,065,366 (GRCm39) K4112* probably null Het
Aspdh A G 7: 44,114,963 (GRCm39) probably null Het
Atf7ip T C 6: 136,583,725 (GRCm39) I1252T probably damaging Het
Avpr1a A G 10: 122,285,367 (GRCm39) T220A possibly damaging Het
Bdp1 A G 13: 100,178,778 (GRCm39) F1856S possibly damaging Het
Cit A T 5: 116,083,896 (GRCm39) N743I probably benign Het
Clvs2 T C 10: 33,471,784 (GRCm39) K174E probably damaging Het
Cyp4f40 A T 17: 32,893,222 (GRCm39) Q351L probably damaging Het
Dmbt1 G T 7: 130,672,919 (GRCm39) V550L possibly damaging Het
Edem1 T G 6: 108,813,738 (GRCm39) S178A probably damaging Het
Fam222b C T 11: 78,044,934 (GRCm39) A165V probably benign Het
Fer T C 17: 64,203,262 (GRCm39) V64A possibly damaging Het
Fggy T G 4: 95,814,986 (GRCm39) F535C possibly damaging Het
Fkbp15 A T 4: 62,222,627 (GRCm39) S1091T probably damaging Het
Fstl5 G A 3: 76,229,498 (GRCm39) V100M probably damaging Het
Fut7 G T 2: 25,315,155 (GRCm39) V91L probably damaging Het
Gemin4 A T 11: 76,103,067 (GRCm39) C565S probably damaging Het
Gzmm C T 10: 79,530,897 (GRCm39) T233I possibly damaging Het
Hps5 A T 7: 46,418,804 (GRCm39) L789Q possibly damaging Het
Krt32 G A 11: 99,974,876 (GRCm39) S357F possibly damaging Het
Lrig2 C T 3: 104,401,512 (GRCm39) probably benign Het
Lrp8 C A 4: 107,718,431 (GRCm39) Q678K probably benign Het
Mmp27 C A 9: 7,571,591 (GRCm39) Q45K probably benign Het
Myh1 A G 11: 67,099,896 (GRCm39) D602G possibly damaging Het
Nol9 T C 4: 152,125,559 (GRCm39) V170A possibly damaging Het
Notch2 A G 3: 98,053,460 (GRCm39) D2041G probably damaging Het
Nrg3 G T 14: 38,390,256 (GRCm39) probably benign Het
Nuak1 T A 10: 84,276,085 (GRCm39) H46L probably damaging Het
Pdzd2 G T 15: 12,374,427 (GRCm39) Q1903K probably benign Het
Pik3c2g T C 6: 139,913,554 (GRCm39) V616A probably damaging Het
Ppp6c A G 2: 39,116,229 (GRCm39) Y9H probably damaging Het
Prdm11 A T 2: 92,843,234 (GRCm39) F75Y probably damaging Het
Prelid1 G A 13: 55,472,219 (GRCm39) V132I probably benign Het
Prom1 A G 5: 44,201,740 (GRCm39) S227P probably damaging Het
Psmb5 G A 14: 54,854,083 (GRCm39) R132C probably benign Het
Pus10 A G 11: 23,668,602 (GRCm39) N360D probably damaging Het
Pygm G A 19: 6,443,868 (GRCm39) V610M probably damaging Het
Setd1a A G 7: 127,384,349 (GRCm39) probably benign Het
Sfmbt1 T A 14: 30,538,759 (GRCm39) W793R probably damaging Het
Slc25a4 A G 8: 46,662,187 (GRCm39) L157P probably damaging Het
Sost T G 11: 101,855,084 (GRCm39) E75A possibly damaging Het
Tdrd9 A G 12: 111,958,922 (GRCm39) S119G possibly damaging Het
Tepsin A G 11: 119,984,954 (GRCm39) I238T probably benign Het
Tfr2 T A 5: 137,581,081 (GRCm39) L507* probably null Het
Tmem106a T C 11: 101,477,121 (GRCm39) I110T possibly damaging Het
Tmem38a A T 8: 73,339,926 (GRCm39) D298V possibly damaging Het
Tmprss12 A T 15: 100,183,262 (GRCm39) R201S probably benign Het
Ugt2b36 T C 5: 87,238,759 (GRCm39) T271A possibly damaging Het
Virma T G 4: 11,514,096 (GRCm39) V650G probably benign Het
Vmn1r220 A T 13: 23,368,162 (GRCm39) I178N probably damaging Het
Zfp609 A G 9: 65,604,901 (GRCm39) S1276P possibly damaging Het
Zfp809 A G 9: 22,146,398 (GRCm39) Y29C probably damaging Het
Other mutations in Ncoa1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00598:Ncoa1 APN 12 4,328,218 (GRCm39) missense probably benign
IGL01335:Ncoa1 APN 12 4,347,520 (GRCm39) missense probably benign 0.31
IGL02111:Ncoa1 APN 12 4,324,944 (GRCm39) start codon destroyed probably null
IGL02863:Ncoa1 APN 12 4,347,513 (GRCm39) missense probably benign 0.00
IGL03007:Ncoa1 APN 12 4,389,114 (GRCm39) missense possibly damaging 0.92
IGL03031:Ncoa1 APN 12 4,324,818 (GRCm39) missense possibly damaging 0.76
IGL03048:Ncoa1 UTSW 12 4,317,922 (GRCm39) missense probably damaging 0.96
IGL03147:Ncoa1 UTSW 12 4,309,342 (GRCm39) missense probably damaging 1.00
PIT1430001:Ncoa1 UTSW 12 4,373,005 (GRCm39) missense probably benign 0.19
PIT4402001:Ncoa1 UTSW 12 4,344,987 (GRCm39) missense probably benign 0.00
R0002:Ncoa1 UTSW 12 4,340,885 (GRCm39) missense probably benign 0.00
R0011:Ncoa1 UTSW 12 4,372,896 (GRCm39) missense possibly damaging 0.94
R0389:Ncoa1 UTSW 12 4,345,976 (GRCm39) missense probably benign 0.05
R0467:Ncoa1 UTSW 12 4,317,687 (GRCm39) missense possibly damaging 0.49
R0480:Ncoa1 UTSW 12 4,389,105 (GRCm39) missense probably damaging 1.00
R0541:Ncoa1 UTSW 12 4,373,033 (GRCm39) missense probably damaging 1.00
R0671:Ncoa1 UTSW 12 4,299,758 (GRCm39) splice site probably null
R1387:Ncoa1 UTSW 12 4,324,790 (GRCm39) missense probably benign 0.01
R1426:Ncoa1 UTSW 12 4,320,737 (GRCm39) splice site probably benign
R1538:Ncoa1 UTSW 12 4,320,748 (GRCm39) missense possibly damaging 0.94
R1577:Ncoa1 UTSW 12 4,345,196 (GRCm39) missense probably damaging 0.99
R1902:Ncoa1 UTSW 12 4,389,049 (GRCm39) missense possibly damaging 0.78
R1905:Ncoa1 UTSW 12 4,345,433 (GRCm39) missense probably damaging 1.00
R2026:Ncoa1 UTSW 12 4,317,647 (GRCm39) missense probably benign 0.19
R2259:Ncoa1 UTSW 12 4,365,819 (GRCm39) missense probably damaging 1.00
R2317:Ncoa1 UTSW 12 4,325,189 (GRCm39) missense probably damaging 0.99
R3608:Ncoa1 UTSW 12 4,328,186 (GRCm39) missense probably benign 0.00
R4042:Ncoa1 UTSW 12 4,317,871 (GRCm39) missense probably damaging 0.99
R4688:Ncoa1 UTSW 12 4,365,781 (GRCm39) missense probably benign 0.26
R4763:Ncoa1 UTSW 12 4,325,297 (GRCm39) missense probably damaging 1.00
R4878:Ncoa1 UTSW 12 4,325,004 (GRCm39) missense probably damaging 1.00
R5062:Ncoa1 UTSW 12 4,309,333 (GRCm39) missense probably damaging 0.99
R5531:Ncoa1 UTSW 12 4,303,746 (GRCm39) missense probably benign
R6393:Ncoa1 UTSW 12 4,328,181 (GRCm39) missense probably benign 0.00
R6711:Ncoa1 UTSW 12 4,372,904 (GRCm39) missense probably benign 0.26
R7066:Ncoa1 UTSW 12 4,372,934 (GRCm39) missense possibly damaging 0.90
R7109:Ncoa1 UTSW 12 4,372,978 (GRCm39) missense possibly damaging 0.63
R7170:Ncoa1 UTSW 12 4,299,722 (GRCm39) missense probably benign 0.32
R7395:Ncoa1 UTSW 12 4,345,188 (GRCm39) missense not run
R7453:Ncoa1 UTSW 12 4,309,307 (GRCm39) missense probably damaging 1.00
R7556:Ncoa1 UTSW 12 4,320,794 (GRCm39) missense probably damaging 0.98
R7821:Ncoa1 UTSW 12 4,346,221 (GRCm39) missense probably benign 0.00
R7872:Ncoa1 UTSW 12 4,328,186 (GRCm39) missense probably benign 0.00
R7885:Ncoa1 UTSW 12 4,389,044 (GRCm39) missense probably damaging 1.00
R7936:Ncoa1 UTSW 12 4,385,873 (GRCm39) missense possibly damaging 0.53
R7940:Ncoa1 UTSW 12 4,363,095 (GRCm39) missense possibly damaging 0.50
R8126:Ncoa1 UTSW 12 4,340,951 (GRCm39) missense probably damaging 1.00
R8176:Ncoa1 UTSW 12 4,317,858 (GRCm39) missense possibly damaging 0.90
R8492:Ncoa1 UTSW 12 4,313,473 (GRCm39) missense probably damaging 1.00
R8510:Ncoa1 UTSW 12 4,309,303 (GRCm39) missense probably benign
R8772:Ncoa1 UTSW 12 4,372,940 (GRCm39) missense possibly damaging 0.63
R9082:Ncoa1 UTSW 12 4,346,106 (GRCm39) missense probably benign 0.02
R9094:Ncoa1 UTSW 12 4,345,494 (GRCm39) missense possibly damaging 0.86
R9238:Ncoa1 UTSW 12 4,325,177 (GRCm39) missense possibly damaging 0.95
R9434:Ncoa1 UTSW 12 4,365,755 (GRCm39) missense probably benign
R9491:Ncoa1 UTSW 12 4,340,912 (GRCm39) missense probably benign 0.20
R9542:Ncoa1 UTSW 12 4,325,178 (GRCm39) missense possibly damaging 0.57
R9625:Ncoa1 UTSW 12 4,345,643 (GRCm39) missense probably damaging 1.00
Z1177:Ncoa1 UTSW 12 4,356,514 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18