Incidental Mutation 'IGL03136:Vmn1r223'
ID410511
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r223
Ensembl Gene ENSMUSG00000069280
Gene Namevomeronasal 1 receptor 223
SynonymsGm11330
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL03136
Quality Score
Status
Chromosome13
Chromosomal Location23249238-23250323 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 23249763 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 176 (T176A)
Ref Sequence ENSEMBL: ENSMUSP00000089312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091719]
Predicted Effect possibly damaging
Transcript: ENSMUST00000091719
AA Change: T176A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000089312
Gene: ENSMUSG00000069280
AA Change: T176A

DomainStartEndE-ValueType
low complexity region 46 59 N/A INTRINSIC
Pfam:TAS2R 63 355 6.6e-10 PFAM
Pfam:V1R 94 357 2.1e-39 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730522E02Rik A G 11: 25,769,122 L7S unknown Het
Abr C T 11: 76,425,295 W571* probably null Het
Adam18 A T 8: 24,641,836 C420S probably damaging Het
Akap5 G T 12: 76,329,875 E694* probably null Het
Bbs1 T C 19: 4,890,991 K565R probably benign Het
Brix1 A G 15: 10,478,766 F189S probably damaging Het
Cnot4 C A 6: 35,051,241 R480L probably damaging Het
Ctu2 A G 8: 122,479,201 probably benign Het
Dhcr7 A G 7: 143,847,366 H422R probably damaging Het
Dock1 A G 7: 135,168,389 M1793V probably benign Het
Dock7 A G 4: 99,003,791 F853L probably damaging Het
Fkbp15 G A 4: 62,340,229 probably benign Het
Ftsj3 C T 11: 106,253,813 D117N probably damaging Het
Gphn A G 12: 78,481,333 I142V possibly damaging Het
Hsd3b1 G A 3: 98,852,985 A230V probably damaging Het
Hydin G A 8: 110,418,524 A836T probably benign Het
Ift52 G T 2: 163,025,334 E71* probably null Het
Ms4a14 T C 19: 11,304,411 D261G possibly damaging Het
Nid1 G A 13: 13,500,499 V935I probably benign Het
Nrap T C 19: 56,342,255 K1008E possibly damaging Het
Nup210 A C 6: 91,028,861 V1340G probably benign Het
Olfr1442 T A 19: 12,674,967 I254N probably damaging Het
Olfr169 A T 16: 19,566,353 F177I probably damaging Het
Olfr974 T C 9: 39,943,036 Y259H probably damaging Het
Pcdhb15 C A 18: 37,475,014 T433N probably damaging Het
Pdcd6ip T A 9: 113,691,499 N139I probably damaging Het
Pgbd1 A G 13: 21,433,439 V80A possibly damaging Het
Pigw A G 11: 84,877,777 I242T probably benign Het
Prtg T G 9: 72,856,985 V580G possibly damaging Het
Ptpn13 T A 5: 103,543,463 N1065K possibly damaging Het
Qrich1 G A 9: 108,544,918 R577H probably damaging Het
Ryr3 G A 2: 112,675,974 probably benign Het
Selenoi T C 5: 30,257,727 Y197H probably damaging Het
Slc47a2 A G 11: 61,310,765 C343R probably benign Het
Smurf2 A T 11: 106,831,048 D527E probably benign Het
Spam1 C T 6: 24,797,011 probably benign Het
Stkld1 T C 2: 26,951,423 V460A probably benign Het
Tgoln1 G A 6: 72,614,113 R339W probably damaging Het
Tprg T C 16: 25,412,762 probably benign Het
Treml1 T G 17: 48,364,851 probably benign Het
Ttc39b A T 4: 83,237,280 V497E probably damaging Het
Vmn2r75 A T 7: 86,148,703 I634N possibly damaging Het
Vps13c A G 9: 67,950,310 E2608G probably damaging Het
Zfp575 A G 7: 24,585,956 C87R probably damaging Het
Zfp790 T A 7: 29,829,895 Y668* probably null Het
Other mutations in Vmn1r223
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Vmn1r223 APN 13 23250084 missense probably damaging 1.00
IGL01016:Vmn1r223 APN 13 23250067 missense probably damaging 1.00
IGL01353:Vmn1r223 APN 13 23249256 missense unknown
IGL01941:Vmn1r223 APN 13 23250237 missense possibly damaging 0.94
IGL02976:Vmn1r223 APN 13 23249995 missense probably damaging 1.00
IGL03064:Vmn1r223 APN 13 23249983 missense probably damaging 1.00
PIT4812001:Vmn1r223 UTSW 13 23249890 missense probably damaging 0.99
R1468:Vmn1r223 UTSW 13 23249868 missense possibly damaging 0.81
R1468:Vmn1r223 UTSW 13 23249868 missense possibly damaging 0.81
R1592:Vmn1r223 UTSW 13 23249667 missense possibly damaging 0.57
R1640:Vmn1r223 UTSW 13 23250178 missense probably damaging 1.00
R2116:Vmn1r223 UTSW 13 23249662 missense probably damaging 1.00
R3076:Vmn1r223 UTSW 13 23250165 missense probably benign 0.15
R4229:Vmn1r223 UTSW 13 23249415 missense probably benign 0.08
R4230:Vmn1r223 UTSW 13 23249415 missense probably benign 0.08
R5420:Vmn1r223 UTSW 13 23249505 missense probably benign 0.02
R6412:Vmn1r223 UTSW 13 23249655 missense probably benign 0.05
R6424:Vmn1r223 UTSW 13 23250175 missense probably damaging 1.00
R6607:Vmn1r223 UTSW 13 23249749 missense probably damaging 1.00
R6944:Vmn1r223 UTSW 13 23249313 missense unknown
R7256:Vmn1r223 UTSW 13 23249866 missense probably damaging 1.00
R8241:Vmn1r223 UTSW 13 23249812 missense probably benign 0.38
R8315:Vmn1r223 UTSW 13 23250169 missense probably damaging 1.00
R8347:Vmn1r223 UTSW 13 23249850 missense probably damaging 1.00
Posted On2016-08-02