Incidental Mutation 'IGL03202:Zfp941'
| ID |
413017 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp941
|
| Ensembl Gene |
ENSMUSG00000060314 |
| Gene Name |
zinc finger protein 941 |
| Synonyms |
BC066028 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL03202
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
140387362-140402091 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 140392966 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 131
(V131A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101667
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080651]
[ENSMUST00000106052]
[ENSMUST00000150053]
|
| AlphaFold |
Q3URY5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080651
AA Change: V131A
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
AA Change: V131A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106052
AA Change: V131A
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: V131A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
640 |
662 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150053
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 86,909,911 (GRCm39) |
M1T |
probably null |
Het |
| Ace |
T |
A |
11: 105,867,788 (GRCm39) |
I168N |
probably damaging |
Het |
| Actr10 |
T |
G |
12: 70,987,605 (GRCm39) |
C37W |
probably damaging |
Het |
| Atp10b |
T |
C |
11: 43,125,268 (GRCm39) |
|
probably null |
Het |
| Bend5 |
A |
G |
4: 111,290,441 (GRCm39) |
N146D |
possibly damaging |
Het |
| Cacna1b |
A |
G |
2: 24,541,124 (GRCm39) |
F1347L |
probably damaging |
Het |
| Crybg3 |
T |
A |
16: 59,315,072 (GRCm39) |
I2910F |
probably damaging |
Het |
| Cspg4 |
T |
C |
9: 56,805,023 (GRCm39) |
S1945P |
possibly damaging |
Het |
| Cxcr4 |
T |
G |
1: 128,516,641 (GRCm39) |
K340T |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,121,683 (GRCm39) |
Y1433F |
probably damaging |
Het |
| Eif2ak4 |
T |
C |
2: 118,231,101 (GRCm39) |
V77A |
probably damaging |
Het |
| Fscn3 |
A |
T |
6: 28,434,451 (GRCm39) |
H342L |
probably benign |
Het |
| Gm9843 |
T |
C |
16: 76,200,234 (GRCm39) |
|
noncoding transcript |
Het |
| Hdac9 |
T |
C |
12: 34,423,950 (GRCm39) |
E520G |
probably damaging |
Het |
| Itm2b |
G |
A |
14: 73,603,229 (GRCm39) |
P120L |
probably damaging |
Het |
| Itpa |
T |
A |
2: 130,509,859 (GRCm39) |
|
probably benign |
Het |
| Lce1l |
A |
T |
3: 92,757,631 (GRCm39) |
C76S |
unknown |
Het |
| Lin54 |
A |
G |
5: 100,623,673 (GRCm39) |
S55P |
possibly damaging |
Het |
| Lrrc37 |
T |
A |
11: 103,506,199 (GRCm39) |
E1923V |
probably benign |
Het |
| Mtfmt |
C |
A |
9: 65,356,008 (GRCm39) |
P303Q |
probably damaging |
Het |
| Nae1 |
A |
T |
8: 105,244,811 (GRCm39) |
|
probably benign |
Het |
| Ncapd3 |
T |
A |
9: 26,983,011 (GRCm39) |
|
probably benign |
Het |
| Or13a19 |
A |
G |
7: 139,903,019 (GRCm39) |
M136V |
possibly damaging |
Het |
| Or1e22 |
G |
A |
11: 73,377,351 (GRCm39) |
Q100* |
probably null |
Het |
| Pcnx2 |
A |
C |
8: 126,498,783 (GRCm39) |
I1572S |
probably damaging |
Het |
| Piezo2 |
A |
T |
18: 63,144,669 (GRCm39) |
Y2809N |
probably damaging |
Het |
| Pygl |
G |
T |
12: 70,246,420 (GRCm39) |
Q376K |
probably benign |
Het |
| Resf1 |
G |
A |
6: 149,227,937 (GRCm39) |
V328I |
probably benign |
Het |
| Rrp12 |
T |
C |
19: 41,857,205 (GRCm39) |
|
probably null |
Het |
| Sephs1 |
A |
T |
2: 4,894,074 (GRCm39) |
I92F |
possibly damaging |
Het |
| Taar4 |
T |
C |
10: 23,836,692 (GRCm39) |
F101L |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 35,915,375 (GRCm39) |
I2053T |
probably damaging |
Het |
| Tgfbr3 |
T |
G |
5: 107,257,630 (GRCm39) |
|
probably benign |
Het |
| Vmn2r108 |
A |
T |
17: 20,691,319 (GRCm39) |
Y401* |
probably null |
Het |
| Vmn2r87 |
A |
G |
10: 130,333,091 (GRCm39) |
M53T |
probably benign |
Het |
|
| Other mutations in Zfp941 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01393:Zfp941
|
APN |
7 |
140,391,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Zfp941
|
APN |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0025:Zfp941
|
UTSW |
7 |
140,393,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0025:Zfp941
|
UTSW |
7 |
140,393,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0226:Zfp941
|
UTSW |
7 |
140,393,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0945:Zfp941
|
UTSW |
7 |
140,391,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1455:Zfp941
|
UTSW |
7 |
140,392,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1581:Zfp941
|
UTSW |
7 |
140,392,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2474:Zfp941
|
UTSW |
7 |
140,391,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4052:Zfp941
|
UTSW |
7 |
140,392,340 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Zfp941
|
UTSW |
7 |
140,391,503 (GRCm39) |
nonsense |
probably null |
|
|
R4604:Zfp941
|
UTSW |
7 |
140,392,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5170:Zfp941
|
UTSW |
7 |
140,392,870 (GRCm39) |
unclassified |
probably benign |
|
|
R5311:Zfp941
|
UTSW |
7 |
140,391,872 (GRCm39) |
nonsense |
probably null |
|
|
R5505:Zfp941
|
UTSW |
7 |
140,391,830 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5549:Zfp941
|
UTSW |
7 |
140,388,021 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5566:Zfp941
|
UTSW |
7 |
140,392,679 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5723:Zfp941
|
UTSW |
7 |
140,392,763 (GRCm39) |
unclassified |
probably benign |
|
|
R5736:Zfp941
|
UTSW |
7 |
140,392,973 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5861:Zfp941
|
UTSW |
7 |
140,392,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Zfp941
|
UTSW |
7 |
140,392,158 (GRCm39) |
nonsense |
probably null |
|
|
R6058:Zfp941
|
UTSW |
7 |
140,392,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Zfp941
|
UTSW |
7 |
140,392,398 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6488:Zfp941
|
UTSW |
7 |
140,392,663 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6824:Zfp941
|
UTSW |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7356:Zfp941
|
UTSW |
7 |
140,392,028 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7554:Zfp941
|
UTSW |
7 |
140,391,970 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zfp941
|
UTSW |
7 |
140,392,099 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
| Posted On |
2016-08-02 |
Incidental Mutation