Incidental Mutation 'IGL03213:Ednra'
| ID |
413386 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ednra
|
| Ensembl Gene |
ENSMUSG00000031616 |
| Gene Name |
endothelin receptor type A |
| Synonyms |
AEA001, ET-AR, Gpcr10, Mhdaaea1, ETa |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL03213
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
78389658-78451081 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 78446848 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 77
(T77A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000034029
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034029]
|
| AlphaFold |
Q61614 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034029
AA Change: T77A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000034029
Gene: ENSMUSG00000031616
AA Change: T77A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
97 |
370 |
8.4e-36 |
PFAM |
|
low complexity region
|
376 |
394 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146561
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153937
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209273
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
PHENOTYPE: Homozygous inactivation of this gene results in numerous severe craniofacial defects and perinatal lethality. Aberrant middle ear development and cardiac defects, including great vessel malformations and abnormal cardiac outflow tract development, have been observed. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abi1 |
A |
T |
2: 22,831,971 (GRCm39) |
D447E |
probably damaging |
Het |
| Aldh8a1 |
T |
C |
10: 21,260,616 (GRCm39) |
V175A |
probably damaging |
Het |
| Aoc1l3 |
A |
G |
6: 48,965,279 (GRCm39) |
D429G |
possibly damaging |
Het |
| Arap2 |
T |
A |
5: 62,906,438 (GRCm39) |
T194S |
probably benign |
Het |
| Arih2 |
T |
C |
9: 108,484,546 (GRCm39) |
T422A |
probably damaging |
Het |
| Arl5b |
T |
A |
2: 15,074,676 (GRCm39) |
N52K |
probably damaging |
Het |
| Atg13 |
G |
A |
2: 91,515,512 (GRCm39) |
H227Y |
probably damaging |
Het |
| Ccdc178 |
T |
C |
18: 22,253,748 (GRCm39) |
T164A |
possibly damaging |
Het |
| Cep192 |
T |
C |
18: 67,998,708 (GRCm39) |
V2074A |
probably damaging |
Het |
| Ces2c |
T |
C |
8: 105,574,672 (GRCm39) |
I43T |
probably benign |
Het |
| Chrm3 |
G |
A |
13: 9,928,220 (GRCm39) |
T272I |
probably benign |
Het |
| Cln8 |
A |
G |
8: 14,944,845 (GRCm39) |
Y53C |
probably damaging |
Het |
| Cwc27 |
T |
A |
13: 104,932,911 (GRCm39) |
|
probably benign |
Het |
| Cyp3a13 |
A |
T |
5: 137,892,529 (GRCm39) |
|
probably benign |
Het |
| Dchs1 |
G |
T |
7: 105,404,279 (GRCm39) |
N2754K |
probably damaging |
Het |
| Dclk1 |
A |
T |
3: 55,387,805 (GRCm39) |
K84* |
probably null |
Het |
| Epn2 |
T |
C |
11: 61,410,510 (GRCm39) |
N553D |
probably damaging |
Het |
| Fut2 |
C |
T |
7: 45,300,193 (GRCm39) |
G193E |
possibly damaging |
Het |
| Gm10784 |
T |
A |
13: 50,099,310 (GRCm39) |
|
noncoding transcript |
Het |
| Gtf2e2 |
T |
C |
8: 34,242,525 (GRCm39) |
F76L |
probably damaging |
Het |
| Hnrnpll |
A |
T |
17: 80,341,527 (GRCm39) |
V504E |
probably damaging |
Het |
| Ifitm2 |
A |
G |
7: 140,535,677 (GRCm39) |
V51A |
possibly damaging |
Het |
| Il16 |
C |
T |
7: 83,295,708 (GRCm39) |
E456K |
probably damaging |
Het |
| Lmod2 |
A |
T |
6: 24,603,615 (GRCm39) |
I197F |
possibly damaging |
Het |
| Lrrc14 |
T |
C |
15: 76,597,983 (GRCm39) |
S238P |
possibly damaging |
Het |
| Map3k1 |
A |
G |
13: 111,885,426 (GRCm39) |
|
probably benign |
Het |
| Phf11d |
C |
A |
14: 59,586,797 (GRCm39) |
R210S |
probably benign |
Het |
| Pigu |
T |
C |
2: 155,177,291 (GRCm39) |
N103S |
probably damaging |
Het |
| Rgsl1 |
A |
G |
1: 153,701,587 (GRCm39) |
V289A |
probably benign |
Het |
| Rp1l1 |
T |
A |
14: 64,265,864 (GRCm39) |
S483R |
probably damaging |
Het |
| Ryr2 |
A |
T |
13: 11,739,273 (GRCm39) |
|
probably benign |
Het |
| Sema3c |
T |
G |
5: 17,899,637 (GRCm39) |
|
probably benign |
Het |
| Septin4 |
G |
T |
11: 87,458,184 (GRCm39) |
|
probably null |
Het |
| Sfmbt2 |
A |
G |
2: 10,409,385 (GRCm39) |
Y110C |
probably damaging |
Het |
| Slc12a3 |
T |
C |
8: 95,061,933 (GRCm39) |
V328A |
possibly damaging |
Het |
| Smarca2 |
G |
A |
19: 26,601,375 (GRCm39) |
G31D |
probably damaging |
Het |
| Spmip1 |
G |
A |
6: 29,471,792 (GRCm39) |
M89I |
probably damaging |
Het |
| Tenm2 |
T |
G |
11: 35,914,157 (GRCm39) |
E2460A |
probably benign |
Het |
| Trim58 |
T |
A |
11: 58,541,993 (GRCm39) |
W318R |
probably benign |
Het |
| Ube3a |
C |
T |
7: 58,935,870 (GRCm39) |
Q585* |
probably null |
Het |
| Vmn2r17 |
T |
C |
5: 109,582,256 (GRCm39) |
|
probably null |
Het |
| Zfp647 |
A |
G |
15: 76,796,177 (GRCm39) |
V161A |
possibly damaging |
Het |
|
| Other mutations in Ednra |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00899:Ednra
|
APN |
8 |
78,401,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02943:Ednra
|
APN |
8 |
78,446,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Starved
|
UTSW |
8 |
78,401,696 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0058:Ednra
|
UTSW |
8 |
78,393,951 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0080:Ednra
|
UTSW |
8 |
78,401,688 (GRCm39) |
missense |
probably benign |
|
|
R0894:Ednra
|
UTSW |
8 |
78,446,649 (GRCm39) |
splice site |
probably benign |
|
|
R1746:Ednra
|
UTSW |
8 |
78,398,211 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1872:Ednra
|
UTSW |
8 |
78,447,025 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1934:Ednra
|
UTSW |
8 |
78,415,747 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R3776:Ednra
|
UTSW |
8 |
78,401,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ednra
|
UTSW |
8 |
78,401,677 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4274:Ednra
|
UTSW |
8 |
78,446,931 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4544:Ednra
|
UTSW |
8 |
78,401,540 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4697:Ednra
|
UTSW |
8 |
78,391,624 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4704:Ednra
|
UTSW |
8 |
78,394,592 (GRCm39) |
intron |
probably benign |
|
|
R4863:Ednra
|
UTSW |
8 |
78,394,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5265:Ednra
|
UTSW |
8 |
78,394,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Ednra
|
UTSW |
8 |
78,401,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5772:Ednra
|
UTSW |
8 |
78,401,696 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6005:Ednra
|
UTSW |
8 |
78,401,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6147:Ednra
|
UTSW |
8 |
78,393,951 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R6384:Ednra
|
UTSW |
8 |
78,415,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6743:Ednra
|
UTSW |
8 |
78,401,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7084:Ednra
|
UTSW |
8 |
78,391,734 (GRCm39) |
nonsense |
probably null |
|
|
R8345:Ednra
|
UTSW |
8 |
78,415,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9421:Ednra
|
UTSW |
8 |
78,391,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9497:Ednra
|
UTSW |
8 |
78,446,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9498:Ednra
|
UTSW |
8 |
78,446,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Ednra
|
UTSW |
8 |
78,393,961 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Posted On |
2016-08-02 |
Incidental Mutation