Incidental Mutation 'IGL03232:Fam166a'
ID413947
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam166a
Ensembl Gene ENSMUSG00000026969
Gene Namefamily with sequence similarity 166, member A
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL03232
Quality Score
Status
Chromosome2
Chromosomal Location25218745-25222280 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 25221739 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 277 (R277*)
Ref Sequence ENSEMBL: ENSMUSP00000028346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028346] [ENSMUST00000043584]
Predicted Effect probably null
Transcript: ENSMUST00000028346
AA Change: R277*
SMART Domains Protein: ENSMUSP00000028346
Gene: ENSMUSG00000026969
AA Change: R277*

DomainStartEndE-ValueType
Pfam:DUF2475 13 71 8.1e-16 PFAM
low complexity region 130 139 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000043584
SMART Domains Protein: ENSMUSP00000042342
Gene: ENSMUSG00000036752

DomainStartEndE-ValueType
Tubulin 47 244 1.04e-67 SMART
Tubulin_C 246 383 3.89e-49 SMART
low complexity region 428 445 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139988
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145607
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c19 A G 13: 4,238,463 T147A probably damaging Het
Bdp1 A G 13: 100,051,481 L1532S probably damaging Het
Btbd3 G A 2: 138,284,143 A416T probably damaging Het
Cacna1e C T 1: 154,493,358 R311H probably damaging Het
Cers2 T G 3: 95,320,157 V32G probably damaging Het
Cog4 A G 8: 110,880,682 probably null Het
Crybg3 C A 16: 59,530,368 G870C probably damaging Het
Dmxl1 C T 18: 49,878,180 H1135Y probably benign Het
Esr1 A C 10: 4,969,270 K453N probably damaging Het
Gprc5d T C 6: 135,116,664 I82V probably benign Het
Hist1h3c T G 13: 23,745,181 E106A probably damaging Het
Hmcn1 A G 1: 150,770,352 probably benign Het
Loxhd1 A G 18: 77,408,750 T17A probably damaging Het
Lrp1 C T 10: 127,539,376 A4452T probably damaging Het
Morc1 A G 16: 48,630,802 E948G probably benign Het
Mug1 A G 6: 121,878,535 K943E probably benign Het
Olfr1445 C A 19: 12,884,272 Y130* probably null Het
Olfr1463 T A 19: 13,234,977 C242* probably null Het
Olfr498 A G 7: 108,465,605 T94A probably benign Het
Rab21 T C 10: 115,294,862 probably benign Het
Selenoi T C 5: 30,256,261 F140S probably damaging Het
Serpini1 T C 3: 75,638,010 probably benign Het
Sgip1 T C 4: 102,915,054 probably benign Het
Smc1b T C 15: 85,129,720 I83M possibly damaging Het
Smg7 T C 1: 152,840,156 Y1061C probably damaging Het
Thbs2 A T 17: 14,691,413 M1K probably null Het
Ubqlnl A G 7: 104,148,629 S554P possibly damaging Het
Other mutations in Fam166a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01344:Fam166a APN 2 25220333 missense possibly damaging 0.90
IGL01712:Fam166a APN 2 25218792 unclassified probably benign
IGL03056:Fam166a APN 2 25221355 missense possibly damaging 0.73
R0368:Fam166a UTSW 2 25220673 missense probably benign
R0761:Fam166a UTSW 2 25220123 unclassified probably benign
R1997:Fam166a UTSW 2 25220205 missense probably damaging 1.00
R2106:Fam166a UTSW 2 25220651 missense probably damaging 0.99
R4575:Fam166a UTSW 2 25220288 missense probably benign 0.00
R4576:Fam166a UTSW 2 25220288 missense probably benign 0.00
R4577:Fam166a UTSW 2 25220288 missense probably benign 0.00
R4578:Fam166a UTSW 2 25220288 missense probably benign 0.00
R5829:Fam166a UTSW 2 25218857 critical splice donor site probably null
R5896:Fam166a UTSW 2 25220566 missense probably benign
R6618:Fam166a UTSW 2 25220623 missense probably benign 0.02
R6905:Fam166a UTSW 2 25220479 missense probably benign 0.00
R7178:Fam166a UTSW 2 25220240 missense probably damaging 0.99
R7636:Fam166a UTSW 2 25218820 missense probably damaging 0.99
Posted On2016-08-02