Incidental Mutation 'IGL03303:Slfn2'
ID 416311
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slfn2
Ensembl Gene ENSMUSG00000072620
Gene Name schlafen 2
Synonyms Shlf2
Accession Numbers

MGI: 1313258

Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock # IGL03303
Quality Score
Status
Chromosome 11
Chromosomal Location 83065112-83070678 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 83069467 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 91 (V91I)
Ref Sequence ENSEMBL: ENSMUSP00000035562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038038]
AlphaFold Q9Z0I6
Predicted Effect possibly damaging
Transcript: ENSMUST00000038038
AA Change: V91I

PolyPhen 2 Score 0.823 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000035562
Gene: ENSMUSG00000072620
AA Change: V91I

DomainStartEndE-ValueType
low complexity region 162 172 N/A INTRINSIC
Pfam:AlbA_2 231 365 4.5e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214134
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit increased susceptibility to bacterial and viral infections, reduced T cell numbers, decreased T cell proliferation, and increased apoptosis of activated T cells. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Chemically induced(1)

Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 36,870,077 E17G possibly damaging Het
A2m T A 6: 121,667,163 V940E probably damaging Het
Agap1 T A 1: 89,665,152 V307D probably damaging Het
Amd1 A G 10: 40,290,125 V286A possibly damaging Het
Chrne T C 11: 70,615,100 K453R possibly damaging Het
Ckm T A 7: 19,414,338 probably benign Het
Ckmt1 A G 2: 121,360,005 T138A probably benign Het
Cldn4 A G 5: 134,946,249 V166A possibly damaging Het
Dclre1a T C 19: 56,546,766 T129A possibly damaging Het
Dlgap2 T A 8: 14,727,812 D352E probably damaging Het
Dnmt1 A G 9: 20,926,710 I236T probably benign Het
Enam G T 5: 88,504,591 V1320L probably benign Het
Ezh1 A C 11: 101,195,671 probably null Het
F13b A T 1: 139,513,036 D410V possibly damaging Het
Fcrl6 A T 1: 172,597,688 Y259N probably damaging Het
Fpr-rs7 A T 17: 20,113,739 F163Y possibly damaging Het
Gpihbp1 C T 15: 75,597,978 Q181* probably null Het
Htr2b T C 1: 86,099,339 probably benign Het
Igkv1-35 A G 6: 70,011,651 I8T probably benign Het
Kcnq2 T C 2: 181,082,389 T584A probably benign Het
Khdrbs3 A G 15: 69,024,823 T111A probably benign Het
Krtap29-1 A T 11: 99,978,843 C71S probably benign Het
Lrrc4c A T 2: 97,629,592 I188F probably damaging Het
Med1 G T 11: 98,158,352 N539K probably damaging Het
Mga T A 2: 119,903,452 D260E probably damaging Het
Mnd1 A G 3: 84,104,937 I155T probably benign Het
Msrb3 T C 10: 120,784,141 D91G probably benign Het
Mycbp2 A T 14: 103,247,758 D1102E probably damaging Het
Nfx1 T A 4: 41,004,323 probably benign Het
Nrsn2 T C 2: 152,374,211 D24G possibly damaging Het
Olfr1262 A T 2: 90,002,466 K20I possibly damaging Het
Osmr T A 15: 6,842,808 R268S probably benign Het
Pelo C A 13: 115,088,661 V343L probably damaging Het
Rp1 T A 1: 4,344,817 N2024I probably damaging Het
Rps6ka2 C T 17: 7,228,012 Q33* probably null Het
Socs6 G T 18: 88,869,744 A349E probably damaging Het
Syt2 A G 1: 134,741,911 N97D probably benign Het
Tas2r123 T A 6: 132,847,438 H99Q probably damaging Het
Tmc3 A G 7: 83,590,725 probably benign Het
Ube2s A T 7: 4,810,477 V35D probably damaging Het
Usp32 A T 11: 85,022,832 V891D probably damaging Het
Vmn1r169 A T 7: 23,578,009 E275D probably benign Het
Vps13c A G 9: 67,934,504 H1936R probably benign Het
Wrap73 C A 4: 154,146,543 A92E probably damaging Het
Zfhx4 C T 3: 5,403,350 T2856M probably damaging Het
Zmym1 A T 4: 127,049,134 I487N probably damaging Het
Other mutations in Slfn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02141:Slfn2 APN 11 83069844 missense probably benign 0.32
IGL02407:Slfn2 APN 11 83069576 missense probably benign 0.00
elektra UTSW 11 83069600 missense probably damaging 1.00
elektra2 UTSW 11 83069564 missense probably benign 0.05
R2270:Slfn2 UTSW 11 83069935 missense probably damaging 0.99
R2392:Slfn2 UTSW 11 83065328 missense possibly damaging 0.91
R3436:Slfn2 UTSW 11 83069564 missense probably benign 0.05
R3437:Slfn2 UTSW 11 83069564 missense probably benign 0.05
R5849:Slfn2 UTSW 11 83069576 missense probably benign 0.00
R7612:Slfn2 UTSW 11 83070263 missense probably damaging 1.00
R7738:Slfn2 UTSW 11 83069973 missense probably damaging 1.00
R8211:Slfn2 UTSW 11 83069759 missense possibly damaging 0.50
R8465:Slfn2 UTSW 11 83069661 missense probably damaging 1.00
R8986:Slfn2 UTSW 11 83069601 missense possibly damaging 0.71
R8987:Slfn2 UTSW 11 83069537 missense probably damaging 0.97
R9627:Slfn2 UTSW 11 83069541 missense
Posted On 2016-08-02