Incidental Mutation 'IGL03110:Lrrc31'
ID419149
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc31
Ensembl Gene ENSMUSG00000074653
Gene Nameleucine rich repeat containing 31
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL03110
Quality Score
Status
Chromosome3
Chromosomal Location30679058-30699843 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 30679266 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 433 (E433G)
Ref Sequence ENSEMBL: ENSMUSP00000120802 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108263] [ENSMUST00000126658]
Predicted Effect probably benign
Transcript: ENSMUST00000108263
SMART Domains Protein: ENSMUSP00000103898
Gene: ENSMUSG00000074653

DomainStartEndE-ValueType
LRR 92 119 4.5e-2 SMART
Blast:LRR 148 175 1e-8 BLAST
LRR 176 203 2.6e-1 SMART
LRR 204 231 6.7e-2 SMART
LRR 260 287 1e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126658
AA Change: E433G

PolyPhen 2 Score 0.036 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000120802
Gene: ENSMUSG00000074653
AA Change: E433G

DomainStartEndE-ValueType
LRR 92 119 4.4e-2 SMART
Blast:LRR 148 175 2e-8 BLAST
LRR 176 203 2.5e-1 SMART
LRR 204 231 6.5e-2 SMART
LRR 260 287 9.9e-2 SMART
Pfam:LRR_6 288 307 8.2e-1 PFAM
LRR 372 399 8e-3 SMART
LRR 402 430 2.7e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130204L05Rik C T 3: 91,088,319 R92H unknown Het
Acacb A G 5: 114,195,234 E473G probably damaging Het
Acp7 T C 7: 28,611,039 M458V probably benign Het
Acrbp G T 6: 125,062,473 C485F probably damaging Het
Actn2 T C 13: 12,309,607 I117V probably benign Het
Ahr T C 12: 35,504,971 E383G probably damaging Het
Cacna2d4 A T 6: 119,236,737 H39L probably benign Het
Cdh11 G T 8: 102,673,870 N155K probably damaging Het
Cldnd1 T A 16: 58,729,596 N47K possibly damaging Het
Ddb1 C T 19: 10,612,945 R279W probably damaging Het
Dido1 A T 2: 180,689,342 D104E probably damaging Het
Dnah1 A T 14: 31,266,717 S3386T probably benign Het
Galnt18 T A 7: 111,548,713 E352V probably benign Het
Gm5407 T A 16: 49,297,394 noncoding transcript Het
Gucy1b2 T C 14: 62,433,834 probably benign Het
Guf1 C A 5: 69,558,477 L87I probably damaging Het
Hikeshi A G 7: 89,935,826 S57P probably damaging Het
Igkv17-121 T A 6: 68,036,867 V17D probably damaging Het
Itgad T C 7: 128,185,985 V324A probably damaging Het
Lama1 T A 17: 67,798,986 L2072Q probably benign Het
Mrc1 T A 2: 14,293,478 L715* probably null Het
Nbeal2 T G 9: 110,631,433 K1778Q probably damaging Het
Olfr1032 T A 2: 86,008,598 V274E probably damaging Het
Olfr1260 A T 2: 89,978,149 I124F probably damaging Het
Olfr33 C A 7: 102,713,883 G177C probably damaging Het
Ppp1r3a T A 6: 14,722,065 probably benign Het
Prss37 T C 6: 40,519,050 Y6C probably benign Het
Rapgef6 A G 11: 54,696,089 Q1602R probably damaging Het
Rbm15b T C 9: 106,885,974 T332A probably damaging Het
Snrnp70 C A 7: 45,376,859 probably benign Het
Spidr T C 16: 15,889,754 E893G probably damaging Het
Stxbp2 T C 8: 3,633,342 I74T probably damaging Het
Tgm2 G A 2: 158,131,490 Q234* probably null Het
Thbd T C 2: 148,406,796 D384G probably benign Het
Zan T C 5: 137,420,016 N2940S unknown Het
Zmat3 T A 3: 32,345,552 N100I probably damaging Het
Other mutations in Lrrc31
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0285:Lrrc31 UTSW 3 30684948 missense probably benign 0.02
R0348:Lrrc31 UTSW 3 30689228 missense probably benign 0.14
R0418:Lrrc31 UTSW 3 30689234 missense probably damaging 1.00
R0453:Lrrc31 UTSW 3 30687525 missense probably damaging 1.00
R0613:Lrrc31 UTSW 3 30685035 splice site probably benign
R2243:Lrrc31 UTSW 3 30685030 splice site probably benign
R2248:Lrrc31 UTSW 3 30689901 missense possibly damaging 0.95
R4093:Lrrc31 UTSW 3 30695522 missense probably damaging 1.00
R4781:Lrrc31 UTSW 3 30687377 intron probably benign
R4805:Lrrc31 UTSW 3 30691297 nonsense probably null
R4835:Lrrc31 UTSW 3 30679157 missense probably damaging 0.97
R4893:Lrrc31 UTSW 3 30679297 missense probably benign 0.02
R4936:Lrrc31 UTSW 3 30689268 missense probably damaging 1.00
R5063:Lrrc31 UTSW 3 30689936 missense possibly damaging 0.78
R5135:Lrrc31 UTSW 3 30684890 nonsense probably null
R5527:Lrrc31 UTSW 3 30691228 missense probably damaging 1.00
R5607:Lrrc31 UTSW 3 30689845 splice site probably null
R5608:Lrrc31 UTSW 3 30689845 splice site probably null
R5611:Lrrc31 UTSW 3 30691155 critical splice donor site probably null
R5865:Lrrc31 UTSW 3 30679140 missense probably benign 0.01
R6001:Lrrc31 UTSW 3 30691169 missense possibly damaging 0.68
R7583:Lrrc31 UTSW 3 30691099 intron probably null
X0027:Lrrc31 UTSW 3 30689279 missense possibly damaging 0.77
Posted On2016-08-02