Incidental Mutation 'IGL01086:Igkv4-59'
ID51275
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv4-59
Ensembl Gene ENSMUSG00000094006
Gene Nameimmunoglobulin kappa variable 4-59
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01086
Quality Score
Status
Chromosome6
Chromosomal Location69438218-69438741 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 69438723 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 7 (I7V)
Ref Sequence ENSEMBL: ENSMUSP00000100155 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103354]
Predicted Effect probably benign
Transcript: ENSMUST00000103354
AA Change: I7V

PolyPhen 2 Score 0.398 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000100155
Gene: ENSMUSG00000094006
AA Change: I7V

DomainStartEndE-ValueType
IGv 40 111 7.11e-18 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,648,863 R104S probably damaging Het
Aen G A 7: 78,907,302 M299I probably damaging Het
Aim2 A G 1: 173,455,433 Y27C probably damaging Het
Apol7b T C 15: 77,423,914 E127G probably damaging Het
Atp10a T C 7: 58,824,318 F1118L probably damaging Het
Cacna1e T C 1: 154,471,601 D940G probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Clip4 G A 17: 71,824,794 V376I probably benign Het
Coro6 C A 11: 77,466,548 C194* probably null Het
Crebbp T C 16: 4,179,552 M223V probably benign Het
Dkk4 T A 8: 22,626,841 C157S probably damaging Het
Dnah14 T C 1: 181,752,046 L3048S probably benign Het
Dscaml1 T C 9: 45,702,662 probably benign Het
Gpr1 T C 1: 63,183,491 E195G probably benign Het
Gria2 T C 3: 80,692,381 Y732C probably damaging Het
Lamc3 T C 2: 31,898,476 F216S probably damaging Het
Lcn6 T C 2: 25,680,780 F61L probably benign Het
Nup205 T A 6: 35,208,936 probably benign Het
Olfr1143 T A 2: 87,803,200 Y266* probably null Het
Otof C T 5: 30,376,273 probably null Het
Pik3c2b T C 1: 133,091,618 C1035R probably damaging Het
Pla1a T C 16: 38,407,622 N298D probably benign Het
Poteg T A 8: 27,473,620 probably benign Het
Pwp1 T C 10: 85,879,893 probably null Het
Scel A G 14: 103,612,391 I631V probably benign Het
Scn3a T A 2: 65,470,159 M1288L probably benign Het
Serpina11 T A 12: 103,986,070 D147V probably damaging Het
Shroom3 T A 5: 92,948,452 C1266S probably benign Het
Slc12a7 A G 13: 73,814,843 Y1054C probably damaging Het
Srms A G 2: 181,212,423 V117A probably damaging Het
Tmem161b T C 13: 84,222,422 probably benign Het
Tmem94 A T 11: 115,790,284 T158S probably benign Het
Tomm40l T C 1: 171,220,309 probably null Het
Traf6 A G 2: 101,684,783 I95V probably benign Het
Ttc13 A G 8: 124,675,346 I686T probably damaging Het
Zmat2 C T 18: 36,796,110 H104Y probably damaging Het
Other mutations in Igkv4-59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01543:Igkv4-59 APN 6 69438361 missense probably damaging 1.00
IGL03410:Igkv4-59 APN 6 69438466 missense probably damaging 0.99
R7363:Igkv4-59 UTSW 6 69438412 missense probably damaging 1.00
R7818:Igkv4-59 UTSW 6 69438491 missense possibly damaging 0.86
R7876:Igkv4-59 UTSW 6 69438353 missense probably damaging 0.99
R7959:Igkv4-59 UTSW 6 69438353 missense probably damaging 0.99
Posted On2013-06-21