Incidental Mutation 'IGL01086:Or5w18'
ID 50459
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5w18
Ensembl Gene ENSMUSG00000068815
Gene Name olfactory receptor family 5 subfamily W member 18
Synonyms MOR177-14, Olfr1143, GA_x6K02T2Q125-49303473-49304405
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL01086
Quality Score
Chromosome 2
Chromosomal Location 87632735-87633679 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 87633544 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 266 (Y266*)
Ref Sequence ENSEMBL: ENSMUSP00000107194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090708] [ENSMUST00000099852] [ENSMUST00000111568]
AlphaFold Q8VEU8
Predicted Effect probably null
Transcript: ENSMUST00000090708
AA Change: Y270*
SMART Domains Protein: ENSMUSP00000088210
Gene: ENSMUSG00000068815
AA Change: Y270*

Pfam:7tm_4 35 312 2.6e-45 PFAM
Pfam:7tm_1 45 294 5.8e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000099852
AA Change: Y266*
SMART Domains Protein: ENSMUSP00000097438
Gene: ENSMUSG00000068815
AA Change: Y266*

Pfam:7tm_4 31 307 2e-41 PFAM
Pfam:7tm_1 41 290 4.3e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111568
AA Change: Y266*
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: Y266*

Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,796,729 (GRCm39) R104S probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Aim2 A G 1: 173,282,999 (GRCm39) Y27C probably damaging Het
Apol7b T C 15: 77,308,114 (GRCm39) E127G probably damaging Het
Atp10a T C 7: 58,474,066 (GRCm39) F1118L probably damaging Het
Cacna1e T C 1: 154,347,347 (GRCm39) D940G probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Clip4 G A 17: 72,131,789 (GRCm39) V376I probably benign Het
Cmklr2 T C 1: 63,222,650 (GRCm39) E195G probably benign Het
Coro6 C A 11: 77,357,374 (GRCm39) C194* probably null Het
Crebbp T C 16: 3,997,416 (GRCm39) M223V probably benign Het
Dkk4 T A 8: 23,116,857 (GRCm39) C157S probably damaging Het
Dnah14 T C 1: 181,579,611 (GRCm39) L3048S probably benign Het
Dscaml1 T C 9: 45,613,960 (GRCm39) probably benign Het
Gria2 T C 3: 80,599,688 (GRCm39) Y732C probably damaging Het
Igkv4-59 T C 6: 69,415,707 (GRCm39) I7V probably benign Het
Lamc3 T C 2: 31,788,488 (GRCm39) F216S probably damaging Het
Lcn6 T C 2: 25,570,792 (GRCm39) F61L probably benign Het
Nup205 T A 6: 35,185,871 (GRCm39) probably benign Het
Otof C T 5: 30,533,617 (GRCm39) probably null Het
Pik3c2b T C 1: 133,019,356 (GRCm39) C1035R probably damaging Het
Pla1a T C 16: 38,227,984 (GRCm39) N298D probably benign Het
Poteg T A 8: 27,963,648 (GRCm39) probably benign Het
Pwp1 T C 10: 85,715,757 (GRCm39) probably null Het
Scel A G 14: 103,849,827 (GRCm39) I631V probably benign Het
Scn3a T A 2: 65,300,503 (GRCm39) M1288L probably benign Het
Serpina11 T A 12: 103,952,329 (GRCm39) D147V probably damaging Het
Shroom3 T A 5: 93,096,311 (GRCm39) C1266S probably benign Het
Slc12a7 A G 13: 73,962,962 (GRCm39) Y1054C probably damaging Het
Srms A G 2: 180,854,216 (GRCm39) V117A probably damaging Het
Tmem161b T C 13: 84,370,541 (GRCm39) probably benign Het
Tmem94 A T 11: 115,681,110 (GRCm39) T158S probably benign Het
Tomm40l T C 1: 171,047,878 (GRCm39) probably null Het
Traf6 A G 2: 101,515,128 (GRCm39) I95V probably benign Het
Ttc13 A G 8: 125,402,085 (GRCm39) I686T probably damaging Het
Zmat2 C T 18: 36,929,163 (GRCm39) H104Y probably damaging Het
Other mutations in Or5w18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01670:Or5w18 APN 2 87,633,224 (GRCm39) missense probably benign 0.10
IGL02503:Or5w18 APN 2 87,632,864 (GRCm39) missense probably benign 0.01
R0316:Or5w18 UTSW 2 87,633,525 (GRCm39) missense probably damaging 0.98
R1381:Or5w18 UTSW 2 87,633,480 (GRCm39) missense probably damaging 1.00
R1496:Or5w18 UTSW 2 87,633,212 (GRCm39) missense probably benign 0.00
R1753:Or5w18 UTSW 2 87,633,106 (GRCm39) missense probably benign 0.06
R2013:Or5w18 UTSW 2 87,632,847 (GRCm39) missense probably damaging 0.97
R2370:Or5w18 UTSW 2 87,633,159 (GRCm39) missense probably benign 0.35
R3810:Or5w18 UTSW 2 87,633,396 (GRCm39) missense possibly damaging 0.90
R3812:Or5w18 UTSW 2 87,633,396 (GRCm39) missense possibly damaging 0.90
R3909:Or5w18 UTSW 2 87,633,031 (GRCm39) missense probably benign
R4227:Or5w18 UTSW 2 87,633,219 (GRCm39) missense probably damaging 0.97
R5753:Or5w18 UTSW 2 87,633,596 (GRCm39) missense probably benign 0.05
R6516:Or5w18 UTSW 2 87,633,114 (GRCm39) missense possibly damaging 0.81
R9101:Or5w18 UTSW 2 87,632,924 (GRCm39) missense probably damaging 1.00
R9144:Or5w18 UTSW 2 87,633,482 (GRCm39) missense probably benign 0.02
Z1177:Or5w18 UTSW 2 87,633,572 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21