Incidental Mutation 'IGL01100:Vmn1r176'
| ID |
51536 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r176
|
| Ensembl Gene |
ENSMUSG00000096859 |
| Gene Name |
vomeronasal 1 receptor 176 |
| Synonyms |
Gm5998 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL01100
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23534237-23535151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23535049 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 35
(F35I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153879
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171073]
[ENSMUST00000226319]
[ENSMUST00000226767]
[ENSMUST00000227129]
[ENSMUST00000227661]
[ENSMUST00000228280]
[ENSMUST00000228793]
|
| AlphaFold |
G3UW31 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171073
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000132168
Gene: ENSMUSG00000096859
AA Change: F35I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
5 |
288 |
5.4e-6 |
PFAM |
|
Pfam:TAS2R
|
8 |
295 |
1.8e-13 |
PFAM |
|
Pfam:V1R
|
41 |
295 |
1.7e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226319
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226767
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227129
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227661
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228280
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228793
AA Change: F35I
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
G |
11: 9,224,673 (GRCm39) |
|
probably null |
Het |
| Abca8a |
C |
T |
11: 109,949,249 (GRCm39) |
|
probably null |
Het |
| Acad11 |
A |
G |
9: 103,953,607 (GRCm39) |
T32A |
probably damaging |
Het |
| Ak7 |
T |
A |
12: 105,679,833 (GRCm39) |
N122K |
probably benign |
Het |
| Arrb1 |
A |
T |
7: 99,236,420 (GRCm39) |
|
probably null |
Het |
| Csde1 |
C |
A |
3: 102,947,841 (GRCm39) |
R132S |
possibly damaging |
Het |
| Emilin1 |
A |
G |
5: 31,075,748 (GRCm39) |
H663R |
probably benign |
Het |
| Etaa1 |
A |
G |
11: 17,902,576 (GRCm39) |
|
probably null |
Het |
| Fat3 |
A |
T |
9: 16,286,524 (GRCm39) |
F1000I |
probably damaging |
Het |
| Foxj2 |
T |
C |
6: 122,805,350 (GRCm39) |
L74P |
probably damaging |
Het |
| Gas6 |
C |
T |
8: 13,525,118 (GRCm39) |
V289M |
probably benign |
Het |
| Gm10801 |
A |
T |
2: 98,494,328 (GRCm39) |
Y135F |
probably benign |
Het |
| Ihh |
C |
T |
1: 74,985,601 (GRCm39) |
A295T |
probably damaging |
Het |
| Ip6k2 |
G |
T |
9: 108,682,943 (GRCm39) |
S305I |
probably damaging |
Het |
| Kcnk2 |
A |
G |
1: 189,072,133 (GRCm39) |
V65A |
probably damaging |
Het |
| Kif26b |
G |
A |
1: 178,744,809 (GRCm39) |
C1635Y |
probably benign |
Het |
| Klhdc4 |
G |
A |
8: 122,548,582 (GRCm39) |
Q44* |
probably null |
Het |
| Madd |
C |
A |
2: 90,988,385 (GRCm39) |
R1216L |
probably damaging |
Het |
| Myo15a |
T |
A |
11: 60,401,984 (GRCm39) |
C3076S |
probably damaging |
Het |
| Or1l4 |
A |
T |
2: 37,091,652 (GRCm39) |
H133L |
possibly damaging |
Het |
| Or52e18 |
T |
A |
7: 104,609,202 (GRCm39) |
I246F |
probably benign |
Het |
| Polq |
C |
A |
16: 36,881,474 (GRCm39) |
P934T |
probably benign |
Het |
| Prkaa1 |
A |
T |
15: 5,203,799 (GRCm39) |
K227M |
probably damaging |
Het |
| Psap |
G |
A |
10: 60,135,708 (GRCm39) |
G388S |
probably benign |
Het |
| Repin1 |
A |
G |
6: 48,573,839 (GRCm39) |
E200G |
probably damaging |
Het |
| Samd9l |
C |
A |
6: 3,375,863 (GRCm39) |
S466I |
possibly damaging |
Het |
| Slc5a3 |
A |
G |
16: 91,876,110 (GRCm39) |
|
probably benign |
Het |
| Smg9 |
G |
A |
7: 24,116,376 (GRCm39) |
V314M |
probably damaging |
Het |
| Tktl1 |
G |
A |
X: 73,244,232 (GRCm39) |
R352H |
probably benign |
Het |
| Ube2z |
A |
G |
11: 95,953,849 (GRCm39) |
V123A |
probably damaging |
Het |
| Zdhhc18 |
A |
T |
4: 133,340,269 (GRCm39) |
Y293N |
probably damaging |
Het |
|
| Other mutations in Vmn1r176 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03004:Vmn1r176
|
APN |
7 |
23,534,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4151001:Vmn1r176
|
UTSW |
7 |
23,534,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0195:Vmn1r176
|
UTSW |
7 |
23,535,010 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1186:Vmn1r176
|
UTSW |
7 |
23,535,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1531:Vmn1r176
|
UTSW |
7 |
23,534,536 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1680:Vmn1r176
|
UTSW |
7 |
23,534,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1770:Vmn1r176
|
UTSW |
7 |
23,534,946 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1803:Vmn1r176
|
UTSW |
7 |
23,534,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Vmn1r176
|
UTSW |
7 |
23,534,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2092:Vmn1r176
|
UTSW |
7 |
23,534,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3498:Vmn1r176
|
UTSW |
7 |
23,534,667 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4832:Vmn1r176
|
UTSW |
7 |
23,534,463 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5712:Vmn1r176
|
UTSW |
7 |
23,534,925 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6965:Vmn1r176
|
UTSW |
7 |
23,535,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7105:Vmn1r176
|
UTSW |
7 |
23,534,748 (GRCm39) |
nonsense |
probably null |
|
|
R7839:Vmn1r176
|
UTSW |
7 |
23,534,394 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8262:Vmn1r176
|
UTSW |
7 |
23,534,878 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8870:Vmn1r176
|
UTSW |
7 |
23,534,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9147:Vmn1r176
|
UTSW |
7 |
23,534,785 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9432:Vmn1r176
|
UTSW |
7 |
23,534,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn1r176
|
UTSW |
7 |
23,534,598 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2013-06-21 |
Incidental Mutation