Incidental Mutation 'IGL01121:Zfp579'
ID51598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp579
Ensembl Gene ENSMUSG00000051550
Gene Namezinc finger protein 579
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01121
Quality Score
Status
Chromosome7
Chromosomal Location4983483-4996158 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 4993247 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 555 (C555F)
Ref Sequence ENSEMBL: ENSMUSP00000123963 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108572] [ENSMUST00000162502] [ENSMUST00000162731]
Predicted Effect possibly damaging
Transcript: ENSMUST00000108572
AA Change: C555F

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000104212
Gene: ENSMUSG00000051550
AA Change: C555F

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
low complexity region 16 44 N/A INTRINSIC
ZnF_C2H2 46 68 8.09e-1 SMART
ZnF_C2H2 74 96 2.4e-3 SMART
ZnF_C2H2 102 125 3.83e-2 SMART
low complexity region 157 170 N/A INTRINSIC
low complexity region 189 216 N/A INTRINSIC
low complexity region 250 262 N/A INTRINSIC
ZnF_C2H2 267 289 1.36e-2 SMART
ZnF_C2H2 295 317 5.14e-3 SMART
low complexity region 318 368 N/A INTRINSIC
ZnF_C2H2 382 404 4.34e0 SMART
ZnF_C2H2 410 432 5.06e-2 SMART
ZnF_C2H2 439 461 1.92e-2 SMART
low complexity region 462 492 N/A INTRINSIC
low complexity region 511 525 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159754
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160225
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160808
Predicted Effect probably benign
Transcript: ENSMUST00000162502
SMART Domains Protein: ENSMUSP00000124074
Gene: ENSMUSG00000051550

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
low complexity region 16 44 N/A INTRINSIC
ZnF_C2H2 46 68 8.09e-1 SMART
ZnF_C2H2 74 96 2.4e-3 SMART
ZnF_C2H2 102 125 3.83e-2 SMART
low complexity region 157 170 N/A INTRINSIC
coiled coil region 190 213 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000162731
AA Change: C555F

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000123963
Gene: ENSMUSG00000051550
AA Change: C555F

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
low complexity region 16 44 N/A INTRINSIC
ZnF_C2H2 46 68 8.09e-1 SMART
ZnF_C2H2 74 96 2.4e-3 SMART
ZnF_C2H2 102 125 3.83e-2 SMART
low complexity region 157 170 N/A INTRINSIC
low complexity region 189 216 N/A INTRINSIC
low complexity region 250 262 N/A INTRINSIC
ZnF_C2H2 267 289 1.36e-2 SMART
ZnF_C2H2 295 317 5.14e-3 SMART
low complexity region 318 368 N/A INTRINSIC
ZnF_C2H2 382 404 4.34e0 SMART
ZnF_C2H2 410 432 5.06e-2 SMART
ZnF_C2H2 439 461 1.92e-2 SMART
low complexity region 462 492 N/A INTRINSIC
low complexity region 511 525 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700046A07Rik G A 18: 62,755,148 noncoding transcript Het
4930432E11Rik A T 7: 29,574,001 noncoding transcript Het
Alg3 T C 16: 20,610,647 E31G probably damaging Het
Arhgap29 A G 3: 122,009,863 E764G probably damaging Het
Atp5j2 C A 5: 145,184,568 V68L probably benign Het
Birc6 T A 17: 74,631,038 I2645K probably benign Het
Capn11 A G 17: 45,639,132 S369P probably benign Het
Car4 A T 11: 84,964,346 probably null Het
Ccdc185 C T 1: 182,748,657 V156I probably benign Het
Cpsf2 G T 12: 101,988,706 E245D probably damaging Het
Dnah11 T C 12: 118,050,695 D2019G probably benign Het
Dscc1 A G 15: 55,082,325 probably benign Het
Dzip3 T C 16: 48,944,881 D490G probably benign Het
E2f8 G A 7: 48,867,821 Q745* probably null Het
Fat3 T A 9: 15,998,401 T2102S probably benign Het
Fgf7 C T 2: 126,088,232 probably benign Het
Fstl4 T C 11: 52,814,637 F47L probably benign Het
Gm15097 A T X: 149,804,328 R129S possibly damaging Het
Gm4297 C T X: 24,552,615 D200N probably benign Het
Itgb5 G T 16: 33,919,989 D490Y probably benign Het
Kansl1 A G 11: 104,335,596 S912P probably benign Het
Kcnq3 A T 15: 66,005,977 probably benign Het
Kctd6 A G 14: 8,222,656 H166R possibly damaging Het
Kel T C 6: 41,702,409 D140G probably benign Het
Lrif1 C A 3: 106,735,664 S177* probably null Het
Lrp1 A T 10: 127,583,853 C962* probably null Het
Lypd5 A T 7: 24,351,551 Y29F probably benign Het
Mmrn1 A G 6: 60,975,944 D403G possibly damaging Het
Nhsl1 T G 10: 18,511,710 V244G probably damaging Het
Olfr781 T C 10: 129,332,935 I18T probably benign Het
Ptprd A T 4: 75,954,201 probably benign Het
Rcan2 A T 17: 44,017,884 I69L probably damaging Het
Rprd2 A G 3: 95,776,550 L373P probably damaging Het
Slc10a4 T C 5: 73,007,586 C174R probably damaging Het
Tas2r134 C T 2: 51,627,989 T160I probably damaging Het
Tbc1d19 T A 5: 53,897,062 L464* probably null Het
Tmem45a2 C T 16: 57,040,790 D225N possibly damaging Het
Unc79 G A 12: 103,165,631 C2139Y probably damaging Het
Vmn2r101 G T 17: 19,589,674 G241C probably damaging Het
Vmn2r91 T C 17: 18,136,504 V811A possibly damaging Het
Wdr11 T C 7: 129,628,022 Y844H probably benign Het
Wdr70 T C 15: 7,873,174 K656E possibly damaging Het
Other mutations in Zfp579
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Zfp579 APN 7 4993391 missense probably damaging 0.97
IGL01475:Zfp579 APN 7 4994744 missense probably benign 0.32
IGL01866:Zfp579 APN 7 4994258 missense possibly damaging 0.88
IGL02284:Zfp579 APN 7 4994168 missense probably damaging 0.99
IGL02313:Zfp579 APN 7 4994433 missense probably benign 0.23
R1803:Zfp579 UTSW 7 4993770 missense probably damaging 1.00
R2025:Zfp579 UTSW 7 4993521 nonsense probably null
R2026:Zfp579 UTSW 7 4993521 nonsense probably null
R2027:Zfp579 UTSW 7 4993521 nonsense probably null
R3690:Zfp579 UTSW 7 4994720 missense probably damaging 0.99
R4303:Zfp579 UTSW 7 4993073 utr 3 prime probably benign
R6680:Zfp579 UTSW 7 4993502 missense probably damaging 0.99
R6826:Zfp579 UTSW 7 4994426 missense probably benign 0.01
R6869:Zfp579 UTSW 7 4994461 missense probably benign 0.00
R7304:Zfp579 UTSW 7 4994583 missense probably benign 0.22
R8220:Zfp579 UTSW 7 4993851 missense probably benign 0.15
R8328:Zfp579 UTSW 7 4994867 missense unknown
X0028:Zfp579 UTSW 7 4993933 missense probably damaging 0.99
Posted On2013-06-21