Mutagenetix > Incidental Mutations

Incidental Mutation 'R4303:Zfp579'

322492

Institutional Source

Beutler Lab

Gene Symbol

Zfp579

Ensembl Gene

ENSMUSG00000051550

Gene Name

zinc finger protein 579

Synonyms

MMRRC Submission

041090-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4303 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

4983483-4996158 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 4993073 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123963 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108572] [ENSMUST00000162502] [ENSMUST00000162731]

Predicted Effect

probably benign
Transcript: ENSMUST00000108572

SMART Domains

Protein: ENSMUSP00000104212
Gene: ENSMUSG00000051550

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
low complexity region	189	216	N/A	INTRINSIC
low complexity region	250	262	N/A	INTRINSIC
ZnF_C2H2	267	289	1.36e-2	SMART
ZnF_C2H2	295	317	5.14e-3	SMART
low complexity region	318	368	N/A	INTRINSIC
ZnF_C2H2	382	404	4.34e0	SMART
ZnF_C2H2	410	432	5.06e-2	SMART
ZnF_C2H2	439	461	1.92e-2	SMART
low complexity region	462	492	N/A	INTRINSIC
low complexity region	511	525	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159754

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160225

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160808

Predicted Effect

probably benign
Transcript: ENSMUST00000162502

SMART Domains

Protein: ENSMUSP00000124074
Gene: ENSMUSG00000051550

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
coiled coil region	190	213	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162731

SMART Domains

Protein: ENSMUSP00000123963
Gene: ENSMUSG00000051550

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
low complexity region	16	44	N/A	INTRINSIC
ZnF_C2H2	46	68	8.09e-1	SMART
ZnF_C2H2	74	96	2.4e-3	SMART
ZnF_C2H2	102	125	3.83e-2	SMART
low complexity region	157	170	N/A	INTRINSIC
low complexity region	189	216	N/A	INTRINSIC
low complexity region	250	262	N/A	INTRINSIC
ZnF_C2H2	267	289	1.36e-2	SMART
ZnF_C2H2	295	317	5.14e-3	SMART
low complexity region	318	368	N/A	INTRINSIC
ZnF_C2H2	382	404	4.34e0	SMART
ZnF_C2H2	410	432	5.06e-2	SMART
ZnF_C2H2	439	461	1.92e-2	SMART
low complexity region	462	492	N/A	INTRINSIC
low complexity region	511	525	N/A	INTRINSIC

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.6%
20x: 96.1%

Validation Efficiency

98% (44/45)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb8	T	C	5: 24,401,057	S247P	probably damaging	Het
Atg4b	A	G	1: 93,768,262	E41G	probably benign	Het
Bckdk	T	C	7: 127,905,330		probably benign	Het
Cacna2d1	A	G	5: 16,302,248		probably null	Het
Chaf1a	A	G	17: 56,044,068	D16G	unknown	Het
Defb12	A	G	8: 19,112,721	I65T	probably benign	Het
Dnah7c	T	C	1: 46,748,578	Y3264H	probably damaging	Het
Ehhadh	C	A	16: 21,762,852	K463N	probably damaging	Het
Ehmt2	G	A	17: 34,908,748	R901Q	possibly damaging	Het
Ern2	T	C	7: 122,177,846		probably null	Het
Esp6	A	G	17: 40,565,144	T28A	possibly damaging	Het
Fam189a2	G	A	19: 23,975,629	A439V	probably damaging	Het
Fam189a2	C	T	19: 23,975,638	S436N	probably damaging	Het
Gm17333	A	C	16: 77,852,879		noncoding transcript	Het
Heatr5a	T	C	12: 51,956,225	T165A	probably benign	Het
Hoxa5	T	C	6: 52,204,260	S31G	probably benign	Het
Ift80	A	G	3: 68,894,174	I744T	probably benign	Het
Kalrn	T	C	16: 34,235,391	K853E	probably damaging	Het
Krt36	A	T	11: 100,103,413	D279E	possibly damaging	Het
Map3k11	T	A	19: 5,690,824	V193E	probably damaging	Het
Mrgpra4	T	A	7: 47,980,936	M306L	probably benign	Het
Myo1a	A	G	10: 127,713,733	T428A	probably benign	Het
Nuggc	A	G	14: 65,611,172	H174R	possibly damaging	Het
Olfr293	G	A	7: 86,663,955	V98M	probably benign	Het
Olfr389	A	T	11: 73,776,838	M163K	possibly damaging	Het
Pigr	G	A	1: 130,841,817	D122N	probably benign	Het
Pik3ca	C	T	3: 32,439,935	R349*	probably null	Het
Rfxank	T	C	8: 70,136,212	D89G	probably damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGTGGCGGCGG	7: 97,579,920		probably benign	Het
Serpina1a	A	G	12: 103,854,675	L348P	probably damaging	Het
Shank1	A	G	7: 44,342,474	Y701C	unknown	Het
Six4	G	T	12: 73,112,540	D207E	possibly damaging	Het
Slco3a1	G	T	7: 74,554,528	D21E	probably benign	Het
Sox6	C	T	7: 115,544,469		probably null	Het
Spta1	A	G	1: 174,179,852	N216S	probably damaging	Het
Stard13	T	C	5: 151,062,869	N392S	possibly damaging	Het
Tax1bp1	T	C	6: 52,727,278	V81A	possibly damaging	Het
Trim29	G	T	9: 43,311,122	V83L	probably damaging	Het
Vmn1r90	C	T	7: 14,561,570	W201*	probably null	Het
Wdr31	T	A	4: 62,460,389	N7I	probably damaging	Het
Ypel4	A	G	2: 84,736,807		probably benign	Het
Zfp39	T	C	11: 58,890,017	K640E	probably damaging	Het
Zfp974	C	A	7: 27,910,232	K689N	possibly damaging	Het

Other mutations in Zfp579

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00971:Zfp579	APN	7	4993391	missense	probably damaging	0.97
IGL01121:Zfp579	APN	7	4993247	missense	possibly damaging	0.59
IGL01475:Zfp579	APN	7	4994744	missense	probably benign	0.32
IGL01866:Zfp579	APN	7	4994258	missense	possibly damaging	0.88
IGL02284:Zfp579	APN	7	4994168	missense	probably damaging	0.99
IGL02313:Zfp579	APN	7	4994433	missense	probably benign	0.23
R1803:Zfp579	UTSW	7	4993770	missense	probably damaging	1.00
R2025:Zfp579	UTSW	7	4993521	nonsense	probably null
R2026:Zfp579	UTSW	7	4993521	nonsense	probably null
R2027:Zfp579	UTSW	7	4993521	nonsense	probably null
R3690:Zfp579	UTSW	7	4994720	missense	probably damaging	0.99
R6680:Zfp579	UTSW	7	4993502	missense	probably damaging	0.99
R6826:Zfp579	UTSW	7	4994426	missense	probably benign	0.01
R6869:Zfp579	UTSW	7	4994461	missense	probably benign	0.00
R7304:Zfp579	UTSW	7	4994583	missense	probably benign	0.22
R8220:Zfp579	UTSW	7	4993851	missense	probably benign	0.15
R8328:Zfp579	UTSW	7	4994867	missense	unknown
X0028:Zfp579	UTSW	7	4993933	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TTTATTCACAGAGACAGAGGAACGG -3'
(R):5'- AGCCTTCGAGATGGAGGATG -3'

Sequencing Primer
(F):5'- AACGGGAGCAGACCTTTCG -3'
(R):5'- CACCTATGCGGATTGGGAG -3'

Posted On

2015-06-20