Incidental Mutation 'R6472:Vmn1r237'
| ID |
516398 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r237
|
| Ensembl Gene |
ENSMUSG00000058030 |
| Gene Name |
vomeronasal 1 receptor 237 |
| Synonyms |
V1rf3 |
| MMRRC Submission |
044605-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R6472 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
21534279-21535148 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 21534616 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Asparagine
at position 113
(S113N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076531
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077301]
|
| AlphaFold |
Q8R296 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077301
AA Change: S113N
PolyPhen 2
Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000076531
Gene: ENSMUSG00000058030
AA Change: S113N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
289 |
7.1e-17 |
PFAM |
|
Pfam:V1R
|
34 |
289 |
1.9e-34 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 98.3%
- 20x: 94.4%
|
| Validation Efficiency |
100% (30/30) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932438H23Rik |
A |
T |
16: 90,852,891 (GRCm39) |
S82T |
probably benign |
Het |
| Abca1 |
A |
G |
4: 53,085,991 (GRCm39) |
|
probably null |
Het |
| Ascc3 |
T |
C |
10: 50,596,783 (GRCm39) |
Y1238H |
probably benign |
Het |
| Ccn3 |
A |
T |
15: 54,612,668 (GRCm39) |
T226S |
possibly damaging |
Het |
| Cdadc1 |
T |
C |
14: 59,823,491 (GRCm39) |
T334A |
probably damaging |
Het |
| Csrp3 |
G |
A |
7: 48,485,356 (GRCm39) |
T47I |
possibly damaging |
Het |
| Cyp2f2 |
G |
A |
7: 26,828,649 (GRCm39) |
R173H |
probably damaging |
Het |
| Fads6 |
T |
C |
11: 115,176,962 (GRCm39) |
T165A |
probably damaging |
Het |
| Fbxo30 |
T |
C |
10: 11,166,975 (GRCm39) |
S566P |
probably damaging |
Het |
| Gsn |
A |
G |
2: 35,180,463 (GRCm39) |
|
probably null |
Het |
| Heatr1 |
A |
G |
13: 12,449,111 (GRCm39) |
D1897G |
probably benign |
Het |
| Il2ra |
G |
A |
2: 11,686,780 (GRCm39) |
E204K |
possibly damaging |
Het |
| Kif16b |
G |
T |
2: 142,541,868 (GRCm39) |
|
probably benign |
Het |
| Kif1b |
T |
C |
4: 149,277,053 (GRCm39) |
M1337V |
probably benign |
Het |
| Odr4 |
C |
T |
1: 150,257,273 (GRCm39) |
D230N |
probably benign |
Het |
| Or2a20 |
A |
G |
6: 43,194,293 (GRCm39) |
I149V |
probably benign |
Het |
| Or2aa1 |
G |
A |
11: 59,480,582 (GRCm39) |
T111I |
probably benign |
Het |
| Or7g22 |
T |
A |
9: 19,048,711 (GRCm39) |
C141S |
probably damaging |
Het |
| Or8k41 |
A |
T |
2: 86,313,534 (GRCm39) |
L184* |
probably null |
Het |
| Pappa2 |
T |
C |
1: 158,662,369 (GRCm39) |
D1202G |
probably damaging |
Het |
| Pcp4l1 |
A |
T |
1: 171,002,004 (GRCm39) |
I52N |
possibly damaging |
Het |
| Sis |
C |
T |
3: 72,846,067 (GRCm39) |
W665* |
probably null |
Het |
| Smap2 |
GACTCTAC |
GAC |
4: 120,830,282 (GRCm39) |
|
probably benign |
Het |
| Snrpb2 |
A |
G |
2: 142,910,221 (GRCm39) |
K93R |
possibly damaging |
Het |
| Syt10 |
T |
G |
15: 89,698,761 (GRCm39) |
E194D |
probably benign |
Het |
| Tmem163 |
A |
C |
1: 127,423,471 (GRCm39) |
F264V |
probably benign |
Het |
| Trav3-1 |
G |
T |
14: 52,818,507 (GRCm39) |
E60D |
possibly damaging |
Het |
| Vwa8 |
T |
C |
14: 79,246,610 (GRCm39) |
S651P |
possibly damaging |
Het |
| Wnt3 |
G |
A |
11: 103,699,100 (GRCm39) |
V69I |
possibly damaging |
Het |
|
| Other mutations in Vmn1r237 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01300:Vmn1r237
|
APN |
17 |
21,534,337 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02746:Vmn1r237
|
APN |
17 |
21,534,480 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03112:Vmn1r237
|
APN |
17 |
21,534,368 (GRCm39) |
nonsense |
probably null |
|
|
IGL03351:Vmn1r237
|
APN |
17 |
21,535,099 (GRCm39) |
missense |
probably benign |
0.06 |
|
BB009:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
BB019:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0478:Vmn1r237
|
UTSW |
17 |
21,535,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn1r237
|
UTSW |
17 |
21,534,932 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0616:Vmn1r237
|
UTSW |
17 |
21,534,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn1r237
|
UTSW |
17 |
21,534,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1590:Vmn1r237
|
UTSW |
17 |
21,534,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3022:Vmn1r237
|
UTSW |
17 |
21,534,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4241:Vmn1r237
|
UTSW |
17 |
21,534,925 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4242:Vmn1r237
|
UTSW |
17 |
21,534,925 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4646:Vmn1r237
|
UTSW |
17 |
21,534,400 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5144:Vmn1r237
|
UTSW |
17 |
21,534,688 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R5229:Vmn1r237
|
UTSW |
17 |
21,534,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5334:Vmn1r237
|
UTSW |
17 |
21,534,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5800:Vmn1r237
|
UTSW |
17 |
21,535,069 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5898:Vmn1r237
|
UTSW |
17 |
21,534,813 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6190:Vmn1r237
|
UTSW |
17 |
21,534,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Vmn1r237
|
UTSW |
17 |
21,534,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7932:Vmn1r237
|
UTSW |
17 |
21,534,725 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8008:Vmn1r237
|
UTSW |
17 |
21,534,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8086:Vmn1r237
|
UTSW |
17 |
21,534,509 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9568:Vmn1r237
|
UTSW |
17 |
21,534,777 (GRCm39) |
missense |
probably benign |
|
|
R9631:Vmn1r237
|
UTSW |
17 |
21,534,660 (GRCm39) |
missense |
probably benign |
0.28 |
|
X0011:Vmn1r237
|
UTSW |
17 |
21,534,317 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGCAGCACTTGATTGTAGCC -3'
(R):5'- GCATTGATAATGTCACTGACCTTG -3'
Sequencing Primer
(F):5'- AGCACTTGATTGTAGCCAACTTC -3'
(R):5'- GTCACTGACCTTGTTATGATGAACAG -3'
|
| Posted On |
2018-05-21 |
Incidental Mutation