Incidental Mutation 'R8706:Vmn1r59'
ID |
669275 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r59
|
Ensembl Gene |
ENSMUSG00000074401 |
Gene Name |
vomeronasal 1 receptor 59 |
Synonyms |
V1rd10 |
MMRRC Submission |
068560-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.058)
|
Stock # |
R8706 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
5456826-5457758 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 5457715 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glutamic Acid
at position 15
(V15E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000073768
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000074132]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000074132
AA Change: V15E
PolyPhen 2
Score 0.834 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000073768 Gene: ENSMUSG00000074401 AA Change: V15E
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
289 |
2e-14 |
PFAM |
Pfam:7tm_1
|
20 |
279 |
1.9e-6 |
PFAM |
Pfam:V1R
|
31 |
287 |
3e-16 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.5%
|
Validation Efficiency |
100% (32/32) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adpgk |
C |
T |
9: 59,222,456 (GRCm39) |
T461I |
probably benign |
Het |
Adra2b |
A |
G |
2: 127,206,487 (GRCm39) |
T335A |
probably benign |
Het |
Ap3b1 |
T |
C |
13: 94,545,353 (GRCm39) |
|
probably null |
Het |
C1rl |
T |
C |
6: 124,470,191 (GRCm39) |
|
probably null |
Het |
Ccdc142 |
A |
G |
6: 83,080,678 (GRCm39) |
E470G |
probably damaging |
Het |
Ccm2 |
T |
A |
11: 6,539,447 (GRCm39) |
I163N |
possibly damaging |
Het |
Cdk5rap2 |
A |
T |
4: 70,157,562 (GRCm39) |
F1596L |
probably benign |
Het |
Chrna4 |
A |
T |
2: 180,679,307 (GRCm39) |
F47I |
probably damaging |
Het |
Cx3cl1 |
A |
G |
8: 95,506,876 (GRCm39) |
T294A |
probably benign |
Het |
Dcun1d4 |
C |
T |
5: 73,714,658 (GRCm39) |
T275M |
probably damaging |
Het |
Dpp4 |
T |
C |
2: 62,208,647 (GRCm39) |
I166V |
probably benign |
Het |
Dynap |
C |
T |
18: 70,374,062 (GRCm39) |
E155K |
unknown |
Het |
Fam171b |
A |
G |
2: 83,690,864 (GRCm39) |
T276A |
probably benign |
Het |
Fmo4 |
G |
A |
1: 162,621,592 (GRCm39) |
Q540* |
probably null |
Het |
Gtf2i |
C |
A |
5: 134,278,733 (GRCm39) |
V633F |
probably damaging |
Het |
Kmt5c |
G |
T |
7: 4,749,153 (GRCm39) |
R262L |
probably damaging |
Het |
Lgr5 |
A |
G |
10: 115,288,610 (GRCm39) |
L678P |
probably benign |
Het |
Mrps27 |
T |
C |
13: 99,541,508 (GRCm39) |
V163A |
probably damaging |
Het |
Myh7b |
G |
A |
2: 155,453,669 (GRCm39) |
|
probably null |
Het |
Myo15a |
A |
G |
11: 60,370,443 (GRCm39) |
T1068A |
probably benign |
Het |
Ncor2 |
T |
C |
5: 125,145,010 (GRCm39) |
E369G |
unknown |
Het |
Neb |
T |
A |
2: 52,181,326 (GRCm39) |
M1094L |
probably benign |
Het |
Osbpl10 |
T |
C |
9: 115,036,688 (GRCm39) |
L228P |
probably damaging |
Het |
Phip |
T |
A |
9: 82,787,765 (GRCm39) |
R799S |
possibly damaging |
Het |
Prkn |
T |
C |
17: 11,456,472 (GRCm39) |
S99P |
probably benign |
Het |
Rassf5 |
G |
T |
1: 131,172,782 (GRCm39) |
T29N |
probably benign |
Het |
Spata31g1 |
A |
G |
4: 42,971,776 (GRCm39) |
K370E |
probably benign |
Het |
Tmprss11g |
T |
A |
5: 86,644,404 (GRCm39) |
S147C |
probably damaging |
Het |
Ttn |
G |
A |
2: 76,569,134 (GRCm39) |
T27253I |
probably damaging |
Het |
Wnt6 |
A |
C |
1: 74,821,947 (GRCm39) |
D176A |
possibly damaging |
Het |
|
Other mutations in Vmn1r59 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01684:Vmn1r59
|
APN |
7 |
5,457,299 (GRCm39) |
missense |
probably benign |
0.12 |
IGL02035:Vmn1r59
|
APN |
7 |
5,457,208 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL02039:Vmn1r59
|
APN |
7 |
5,457,380 (GRCm39) |
missense |
probably benign |
0.23 |
IGL02812:Vmn1r59
|
APN |
7 |
5,457,176 (GRCm39) |
missense |
probably damaging |
1.00 |
R0033:Vmn1r59
|
UTSW |
7 |
5,457,433 (GRCm39) |
missense |
probably benign |
0.08 |
R0115:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
R1164:Vmn1r59
|
UTSW |
7 |
5,457,410 (GRCm39) |
missense |
probably benign |
0.00 |
R1629:Vmn1r59
|
UTSW |
7 |
5,457,466 (GRCm39) |
missense |
probably damaging |
1.00 |
R1845:Vmn1r59
|
UTSW |
7 |
5,457,553 (GRCm39) |
missense |
probably benign |
0.03 |
R1969:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
R1970:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
R1971:Vmn1r59
|
UTSW |
7 |
5,457,038 (GRCm39) |
missense |
probably damaging |
1.00 |
R2011:Vmn1r59
|
UTSW |
7 |
5,457,283 (GRCm39) |
missense |
probably damaging |
1.00 |
R3712:Vmn1r59
|
UTSW |
7 |
5,457,637 (GRCm39) |
missense |
probably damaging |
0.99 |
R4580:Vmn1r59
|
UTSW |
7 |
5,457,136 (GRCm39) |
missense |
probably damaging |
0.98 |
R4593:Vmn1r59
|
UTSW |
7 |
5,457,686 (GRCm39) |
missense |
possibly damaging |
0.46 |
R4697:Vmn1r59
|
UTSW |
7 |
5,457,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R4856:Vmn1r59
|
UTSW |
7 |
5,457,532 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4873:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
R4875:Vmn1r59
|
UTSW |
7 |
5,457,108 (GRCm39) |
missense |
probably benign |
|
R4925:Vmn1r59
|
UTSW |
7 |
5,457,115 (GRCm39) |
missense |
probably benign |
0.07 |
R5319:Vmn1r59
|
UTSW |
7 |
5,457,209 (GRCm39) |
missense |
probably damaging |
0.99 |
R6239:Vmn1r59
|
UTSW |
7 |
5,457,539 (GRCm39) |
missense |
probably damaging |
1.00 |
R6533:Vmn1r59
|
UTSW |
7 |
5,457,463 (GRCm39) |
missense |
probably benign |
0.00 |
R6912:Vmn1r59
|
UTSW |
7 |
5,457,599 (GRCm39) |
missense |
probably benign |
0.01 |
R7023:Vmn1r59
|
UTSW |
7 |
5,457,477 (GRCm39) |
missense |
probably benign |
0.37 |
R7205:Vmn1r59
|
UTSW |
7 |
5,457,725 (GRCm39) |
missense |
probably damaging |
1.00 |
R7374:Vmn1r59
|
UTSW |
7 |
5,457,160 (GRCm39) |
missense |
probably damaging |
0.99 |
R7390:Vmn1r59
|
UTSW |
7 |
5,456,986 (GRCm39) |
missense |
possibly damaging |
0.59 |
R7776:Vmn1r59
|
UTSW |
7 |
5,457,634 (GRCm39) |
missense |
probably damaging |
0.97 |
R8306:Vmn1r59
|
UTSW |
7 |
5,456,966 (GRCm39) |
missense |
probably benign |
0.01 |
R8473:Vmn1r59
|
UTSW |
7 |
5,457,064 (GRCm39) |
missense |
possibly damaging |
0.84 |
R8499:Vmn1r59
|
UTSW |
7 |
5,457,750 (GRCm39) |
missense |
probably benign |
0.00 |
R8523:Vmn1r59
|
UTSW |
7 |
5,457,053 (GRCm39) |
missense |
probably damaging |
1.00 |
R9104:Vmn1r59
|
UTSW |
7 |
5,457,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTTGGAGGCTTCCTTGGAAC -3'
(R):5'- AGTGTGTCAAAGCAGTGCCAG -3'
Sequencing Primer
(F):5'- GGAACAAAATCAATCATGTCATGTG -3'
(R):5'- GCAGTGCCAGCTTTTCAAACG -3'
|
Posted On |
2021-04-30 |