Incidental Mutation 'R8834:Rgs10'
ID 674032
Institutional Source Beutler Lab
Gene Symbol Rgs10
Ensembl Gene ENSMUSG00000030844
Gene Name regulator of G-protein signalling 10
Synonyms 2310010N19Rik
MMRRC Submission 068662-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.271) question?
Stock # R8834 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 127975345-128020482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127990809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 93 (I93T)
Ref Sequence ENSEMBL: ENSMUSP00000033133 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033133]
AlphaFold Q9CQE5
Predicted Effect probably damaging
Transcript: ENSMUST00000033133
AA Change: I93T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033133
Gene: ENSMUSG00000030844
AA Change: I93T

DomainStartEndE-ValueType
low complexity region 16 31 N/A INTRINSIC
RGS 41 156 7.05e-46 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,877,372 (GRCm39) T1007A probably benign Het
Adcy6 A G 15: 98,498,922 (GRCm39) L293P possibly damaging Het
Cacna2d1 T A 5: 16,471,735 (GRCm39) V260E possibly damaging Het
Capn3 T A 2: 120,294,534 (GRCm39) F61I probably damaging Het
Cdh9 A G 15: 16,850,964 (GRCm39) S578G probably damaging Het
Cog4 A G 8: 111,608,049 (GRCm39) Y714C probably damaging Het
Dnah14 T G 1: 181,444,315 (GRCm39) F542V possibly damaging Het
Dock8 T C 19: 25,140,834 (GRCm39) V1350A probably benign Het
Eps8 A G 6: 137,504,306 (GRCm39) probably benign Het
Fat3 C T 9: 15,942,493 (GRCm39) G1293E probably damaging Het
Fnip1 T C 11: 54,395,581 (GRCm39) V985A possibly damaging Het
Frem1 T C 4: 82,922,610 (GRCm39) D397G probably damaging Het
Gan C G 8: 117,885,031 (GRCm39) P53R Het
Gcc2 T C 10: 58,121,867 (GRCm39) probably null Het
Glb1l2 C T 9: 26,689,314 (GRCm39) probably null Het
Gm973 T C 1: 59,563,820 (GRCm39) F2L Het
Heatr5a A G 12: 51,956,739 (GRCm39) probably null Het
Kifc2 T A 15: 76,551,250 (GRCm39) H681Q probably damaging Het
Krt16 T A 11: 100,139,236 (GRCm39) S161C probably damaging Het
Lrrc3b A G 14: 15,358,562 (GRCm38) C15R possibly damaging Het
Lrrc66 C G 5: 73,765,928 (GRCm39) A372P possibly damaging Het
Ly75 C T 2: 60,161,433 (GRCm39) R884H probably benign Het
Map2k6 T A 11: 110,383,419 (GRCm39) C109* probably null Het
Mapk9 C T 11: 49,774,010 (GRCm39) S389L probably damaging Het
Mier2 C T 10: 79,386,293 (GRCm39) G57D unknown Het
Mis18bp1 A T 12: 65,208,419 (GRCm39) M98K probably benign Het
Mrtfa A G 15: 80,904,511 (GRCm39) L196P probably benign Het
Or1e17 T C 11: 73,831,164 (GRCm39) F31L possibly damaging Het
Pcsk7 A G 9: 45,830,589 (GRCm39) S456G possibly damaging Het
Phf12 T A 11: 77,897,608 (GRCm39) C102S probably damaging Het
Ppm1k A G 6: 57,502,023 (GRCm39) C47R probably benign Het
Ror2 CCCTCCTCCTCCTCCTC CCCTCCTCCTCCTC 13: 53,264,338 (GRCm39) probably benign Het
Rusc2 T A 4: 43,416,431 (GRCm39) F579Y possibly damaging Het
Selplg G A 5: 113,957,691 (GRCm39) S205L possibly damaging Het
Sh3gl3 T C 7: 81,955,999 (GRCm39) V109A possibly damaging Het
Tanc2 T C 11: 105,807,845 (GRCm39) S336P Het
Tlr2 C A 3: 83,746,020 (GRCm39) R21L probably benign Het
Trpa1 C T 1: 14,963,528 (GRCm39) V565I possibly damaging Het
Ubqln1 A T 13: 58,331,058 (GRCm39) S390T probably damaging Het
Ubr3 T C 2: 69,833,785 (GRCm39) V1514A probably benign Het
Uchl5 A T 1: 143,661,968 (GRCm39) K81* probably null Het
Unc13b T C 4: 43,175,954 (GRCm39) F2261L unknown Het
Usp12 T A 5: 146,691,327 (GRCm39) E142D probably benign Het
V1ra8 A T 6: 90,180,622 (GRCm39) D275V unknown Het
Zfp804a A G 2: 82,089,441 (GRCm39) H1090R possibly damaging Het
Other mutations in Rgs10
AlleleSourceChrCoordTypePredicted EffectPPH Score
comptroller UTSW 7 127,975,733 (GRCm39) missense probably damaging 1.00
R1682:Rgs10 UTSW 7 127,975,694 (GRCm39) missense probably benign
R1714:Rgs10 UTSW 7 128,004,946 (GRCm39) missense probably damaging 0.98
R1801:Rgs10 UTSW 7 128,006,201 (GRCm39) missense possibly damaging 0.67
R2200:Rgs10 UTSW 7 127,990,761 (GRCm39) missense probably damaging 0.99
R3118:Rgs10 UTSW 7 128,004,955 (GRCm39) missense probably damaging 1.00
R3119:Rgs10 UTSW 7 128,004,955 (GRCm39) missense probably damaging 1.00
R6903:Rgs10 UTSW 7 127,990,797 (GRCm39) missense probably damaging 1.00
R8504:Rgs10 UTSW 7 128,019,793 (GRCm39) missense probably benign 0.38
R9153:Rgs10 UTSW 7 127,975,733 (GRCm39) missense probably damaging 1.00
R9709:Rgs10 UTSW 7 127,975,729 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGGAGAACATGGATGGCTTTTC -3'
(R):5'- TGTTTCAGAAGACTTGGCCTC -3'

Sequencing Primer
(F):5'- GCTTTTCAGATTAAGGCACAGGC -3'
(R):5'- GACTTGGCCTCAGAAGCTCTATTAG -3'
Posted On 2021-07-15