|Institutional Source||Beutler Lab|
|Gene Name||syndecan 2|
|Synonyms||4833414L08Rik, Hspg1, Synd2, fibroglycan|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8838 (G1)|
|Chromosomal Location||32920723-33034935 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 33023751 bp (GRCm38)|
|Amino Acid Change||Leucine to Stop codon at position 92 (L92*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022871 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022871]|
AA Change: L92*
AA Change: L92*
|Coding Region Coverage||
|Validation Efficiency||100% (52/52)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sdc2||
(F):5'- AAGCCTGGTAACTTGAGAGC -3'
(R):5'- TGCAAGGAAAAGTGCCATTTTC -3'
(F):5'- CCTGGTAACTTGAGAGCATGATTC -3'
(R):5'- TCCCTAAAGAAGATAGTCCTAGCTG -3'