Incidental Mutation 'R8965:Trgv3'
ID 682689
Institutional Source Beutler Lab
Gene Symbol Trgv3
Ensembl Gene ENSMUSG00000076750
Gene Name T cell receptor gamma, variable 3
Synonyms vgamma3, Tcrg-V3
MMRRC Submission 068799-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R8965 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 19427015-19427471 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19427180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 21 (L21Q)
Ref Sequence ENSEMBL: ENSMUSP00000142927 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103559] [ENSMUST00000198663]
AlphaFold A0A075B5Z1
Predicted Effect probably damaging
Transcript: ENSMUST00000103559
AA Change: L20Q

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000100339
Gene: ENSMUSG00000076750
AA Change: L20Q

DomainStartEndE-ValueType
IGv 34 114 4.92e-12 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000198663
AA Change: L21Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142927
Gene: ENSMUSG00000076750
AA Change: L21Q

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 35 115 2e-14 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T A 13: 77,760,723 (GRCm39) I1260K probably benign Het
Ace3 G T 11: 105,896,175 (GRCm39) C707F probably benign Het
Ahi1 A G 10: 20,839,761 (GRCm39) H224R probably benign Het
Atp1a2 T C 1: 172,107,612 (GRCm39) D669G probably benign Het
Cdk5rap2 A C 4: 70,185,042 (GRCm39) V1136G probably benign Het
Cntnap4 T A 8: 113,479,646 (GRCm39) V277E probably damaging Het
Cyp2d12 T C 15: 82,443,186 (GRCm39) L416P possibly damaging Het
Dnah17 T G 11: 117,915,492 (GRCm39) T4376P probably damaging Het
E4f1 C T 17: 24,664,504 (GRCm39) V429M probably benign Het
Epha8 G T 4: 136,665,897 (GRCm39) L420M probably damaging Het
Erich6 A T 3: 58,531,738 (GRCm39) D419E probably benign Het
Grid2 A G 6: 64,296,990 (GRCm39) E451G probably damaging Het
Herpud1 T C 8: 95,118,469 (GRCm39) Y181H probably damaging Het
Igkv2-109 A T 6: 68,280,112 (GRCm39) Y111F probably damaging Het
Lztr1 T C 16: 17,327,296 (GRCm39) probably null Het
Myh13 A T 11: 67,255,432 (GRCm39) M1601L probably benign Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Or10ag53 A T 2: 87,082,901 (GRCm39) I207F possibly damaging Het
Or2w2 T C 13: 21,758,387 (GRCm39) T80A probably benign Het
Or5p52 T C 7: 107,502,314 (GRCm39) L130P probably damaging Het
P2rx1 T C 11: 72,900,051 (GRCm39) V156A probably benign Het
P3h2 T C 16: 25,791,134 (GRCm39) N444S probably benign Het
Patz1 T C 11: 3,257,815 (GRCm39) Y559H probably damaging Het
Pcna T C 2: 132,094,769 (GRCm39) D63G possibly damaging Het
Pcnx2 G A 8: 126,485,853 (GRCm39) A1915V probably benign Het
Peli1 T C 11: 21,098,488 (GRCm39) Y408H probably damaging Het
Psma5 T A 3: 108,172,510 (GRCm39) probably null Het
Ptpn11 G A 5: 121,301,229 (GRCm39) T205M possibly damaging Het
Rapgef2 A G 3: 78,999,851 (GRCm39) L453P probably damaging Het
Slc12a4 A G 8: 106,671,982 (GRCm39) V910A possibly damaging Het
Spaca6 A G 17: 18,058,718 (GRCm39) T306A probably damaging Het
Spata6 T A 4: 111,680,009 (GRCm39) Y422* probably null Het
Svop A G 5: 114,173,271 (GRCm39) Y367H probably benign Het
Trim38 T C 13: 23,975,006 (GRCm39) L315S possibly damaging Het
Ttc12 A G 9: 49,349,718 (GRCm39) V693A probably benign Het
Usp20 T A 2: 30,901,797 (GRCm39) Y521N possibly damaging Het
Vcam1 T A 3: 115,922,422 (GRCm39) K34* probably null Het
Vwa1 A T 4: 155,857,440 (GRCm39) Y119* probably null Het
Vwa5b2 A G 16: 20,415,076 (GRCm39) H366R possibly damaging Het
Wac C A 18: 7,905,936 (GRCm39) Q168K probably benign Het
Wipf2 A G 11: 98,783,497 (GRCm39) S308G probably benign Het
Zbtb25 A C 12: 76,396,577 (GRCm39) I215S probably benign Het
Zfp677 T C 17: 21,617,155 (GRCm39) S71P probably damaging Het
Other mutations in Trgv3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Trgv3 APN 13 19,427,381 (GRCm39) missense probably benign 0.44
IGL02458:Trgv3 APN 13 19,427,423 (GRCm39) missense probably damaging 0.99
IGL03146:Trgv3 APN 13 19,427,337 (GRCm39) nonsense probably null
R6777:Trgv3 UTSW 13 19,427,450 (GRCm39) missense probably damaging 1.00
R7275:Trgv3 UTSW 13 19,427,188 (GRCm39) missense probably benign 0.20
R7491:Trgv3 UTSW 13 19,427,016 (GRCm39) start codon destroyed probably null 0.99
R8434:Trgv3 UTSW 13 19,427,036 (GRCm39) missense probably benign
R9307:Trgv3 UTSW 13 19,427,441 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CGATGCTGCTCCTGAGAATG -3'
(R):5'- CTGCACAGTAGTAGGTGGCTTC -3'

Sequencing Primer
(F):5'- GATGCTGCTCCTGAGAATGTTCAC -3'
(R):5'- CACAGTAGTAGGTGGCTTCATCTTC -3'
Posted On 2021-10-11