Mutagenetix > Incidental Mutation

Incidental Mutation 'R9162:Or7e175'

695787

Institutional Source

Beutler Lab

Gene Symbol

Or7e175

Ensembl Gene

ENSMUSG00000058491

Gene Name

olfactory receptor family 7 subfamily E member 175

Synonyms

Olfr869, MOR145-6, GA_x6K02T2PVTD-13878275-13879204

MMRRC Submission

068943-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

R9162 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20040305-20050059 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20040457 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 6 (I6V)

Ref Sequence

ENSEMBL: ENSMUSP00000154723 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000213024]

AlphaFold

A0A2I3BRV7

Predicted Effect

probably benign
Transcript: ENSMUST00000213024
AA Change: I6V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

98% (48/49)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb8	A	G	5: 24,611,732 (GRCm39)	D516G	probably damaging	Het
Abcd2	A	G	15: 91,058,926 (GRCm39)	M506T	probably benign	Het
Abhd17a	T	C	10: 80,422,577 (GRCm39)	Y35C	probably damaging	Het
Adamts12	A	G	15: 11,311,721 (GRCm39)	N1326S	probably benign	Het
Arhgef18	T	C	8: 3,414,645 (GRCm39)	Y8H	probably benign	Het
Arsi	T	C	18: 61,050,569 (GRCm39)	V484A	probably damaging	Het
Bsn	T	C	9: 107,987,883 (GRCm39)	D2623G	unknown	Het
Cul9	A	C	17: 46,837,529 (GRCm39)	D1005E	probably benign	Het
Dchs1	A	C	7: 105,414,732 (GRCm39)	V770G	probably damaging	Het
Dcst2	C	A	3: 89,274,088 (GRCm39)	S213*	probably null	Het
Dnah11	C	T	12: 117,991,251 (GRCm39)	E2372K	probably damaging	Het
Dysf	C	T	6: 84,089,215 (GRCm39)	T926I	probably damaging	Het
Ext1	G	A	15: 53,208,504 (GRCm39)	R86*	probably null	Het
Fat1	T	C	8: 45,404,352 (GRCm39)	F368L	probably damaging	Het
Flnc	T	C	6: 29,455,860 (GRCm39)	C2097R	probably damaging	Het
Git1	T	A	11: 77,396,331 (GRCm39)	I565N	probably benign	Het
Gpr22	A	G	12: 31,758,724 (GRCm39)	V466A	probably benign	Het
Hacd4	T	A	4: 88,338,017 (GRCm39)	T194S	probably benign	Het
Hectd4	A	G	5: 121,445,042 (GRCm39)	K93R	possibly damaging	Het
Kcnv1	T	C	15: 44,972,450 (GRCm39)	S478G	possibly damaging	Het
Kmt2a	T	C	9: 44,759,363 (GRCm39)	S829G	probably benign	Het
Lnp1	A	T	16: 56,737,844 (GRCm39)	H81Q	possibly damaging	Het
Lrp1	C	T	10: 127,441,368 (GRCm39)	A252T	probably benign	Het
Msl2	T	C	9: 100,978,928 (GRCm39)	V434A	probably benign	Het
Myo1g	T	A	11: 6,460,897 (GRCm39)	I716F	probably damaging	Het
Or52e19	A	T	7: 102,958,927 (GRCm39)		probably benign	Het
Or56a42-ps1	A	T	7: 104,777,454 (GRCm39)	Y53*	probably null	Het
Or5b12	A	T	19: 12,897,024 (GRCm39)	Y216*	probably null	Het
Pappa	T	A	4: 65,123,040 (GRCm39)	S792T	probably damaging	Het
Pcdhb17	T	C	18: 37,620,168 (GRCm39)	S653P	probably damaging	Het
Plcd4	A	G	1: 74,601,362 (GRCm39)	K574R	probably benign	Het
Scyl3	C	A	1: 163,773,891 (GRCm39)	Q372K	probably benign	Het
Sgsm1	A	T	5: 113,430,577 (GRCm39)	D269E	probably damaging	Het
Siah2	C	A	3: 58,599,104 (GRCm39)	G45C	unknown	Het
Slc4a11	T	A	2: 130,534,214 (GRCm39)	D28V	possibly damaging	Het
Slco1a8	T	A	6: 141,939,453 (GRCm39)	E200V	probably damaging	Het
Socs4	T	A	14: 47,528,301 (GRCm39)	M412K	probably damaging	Het
Spata31e1	T	G	13: 49,939,310 (GRCm39)	Q800P	possibly damaging	Het
Spef2	T	G	15: 9,602,017 (GRCm39)	N1415T	unknown	Het
Stat6	A	G	10: 127,487,089 (GRCm39)	K199E	probably damaging	Het
Syndig1l	A	G	12: 84,727,291 (GRCm39)	F91S	probably damaging	Het
Tank	C	A	2: 61,480,432 (GRCm39)	Q324K	possibly damaging	Het
Tars3	G	A	7: 65,332,518 (GRCm39)	E540K	probably benign	Het
Tial1	A	G	7: 128,050,415 (GRCm39)	V70A	possibly damaging	Het
Tmem87b	C	T	2: 128,681,150 (GRCm39)	T358I	probably benign	Het
Ttyh3	G	A	5: 140,621,820 (GRCm39)	A42V	possibly damaging	Het
Xrn1	T	C	9: 95,915,660 (GRCm39)	I1261T	probably benign	Het
Zfp229	T	C	17: 21,964,495 (GRCm39)	S242P	probably damaging	Het
Zmym2	T	A	14: 57,163,361 (GRCm39)	C638S	probably benign	Het

Other mutations in Or7e175

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00966:Or7e175	APN	9	20,048,531 (GRCm39)	missense	probably benign
IGL01550:Or7e175	APN	9	20,048,750 (GRCm39)	missense	probably damaging	0.97
IGL02247:Or7e175	APN	9	20,048,516 (GRCm39)	missense	probably benign	0.01
IGL02448:Or7e175	APN	9	20,048,937 (GRCm39)	nonsense	probably null
IGL03076:Or7e175	APN	9	20,049,023 (GRCm39)	missense	probably benign	0.25
R0045:Or7e175	UTSW	9	20,048,487 (GRCm39)	missense	probably benign	0.25
R0962:Or7e175	UTSW	9	20,048,834 (GRCm39)	missense	probably damaging	1.00
R4588:Or7e175	UTSW	9	20,049,383 (GRCm39)	makesense	probably null
R4931:Or7e175	UTSW	9	20,048,858 (GRCm39)	missense	probably benign	0.19
R5030:Or7e175	UTSW	9	20,049,363 (GRCm39)	missense	probably benign	0.01
R5759:Or7e175	UTSW	9	20,049,228 (GRCm39)	missense	probably benign	0.12
R5780:Or7e175	UTSW	9	20,048,793 (GRCm39)	missense	probably damaging	0.98
R6440:Or7e175	UTSW	9	20,048,490 (GRCm39)	missense	probably damaging	1.00
R6599:Or7e175	UTSW	9	20,049,239 (GRCm39)	missense	probably damaging	1.00
R6710:Or7e175	UTSW	9	20,049,378 (GRCm39)	missense	probably benign	0.01
R6953:Or7e175	UTSW	9	20,049,299 (GRCm39)	missense	probably benign	0.00
R7288:Or7e175	UTSW	9	20,048,737 (GRCm39)	nonsense	probably null
R7585:Or7e175	UTSW	9	20,040,307 (GRCm39)
R7860:Or7e175	UTSW	9	20,048,871 (GRCm39)	missense	probably benign	0.16
R8025:Or7e175	UTSW	9	20,048,928 (GRCm39)	missense	probably benign	0.01
R8178:Or7e175	UTSW	9	20,048,571 (GRCm39)	missense	possibly damaging	0.94
R8794:Or7e175	UTSW	9	20,048,630 (GRCm39)	missense	possibly damaging	0.94
R8954:Or7e175	UTSW	9	20,048,664 (GRCm39)	missense	probably damaging	1.00
R9116:Or7e175	UTSW	9	20,048,633 (GRCm39)	missense	probably damaging	1.00
R9269:Or7e175	UTSW	9	20,048,757 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCCACTGTCAGGGTTCAAGTTG -3'
(R):5'- CACACTCATATCATTGTAAGACAGC -3'

Sequencing Primer
(F):5'- TTCAAGTTGGAGCACTGACG -3'
(R):5'- CAACTTTGGTGTCTTTGAAAAGC -3'

Posted On

2022-02-07