Incidental Mutation 'R9532:Lyzl6'
ID 719535
Institutional Source Beutler Lab
Gene Symbol Lyzl6
Ensembl Gene ENSMUSG00000020945
Gene Name lysozyme-like 6
Synonyms 1700023H08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R9532 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 103521896-103529716 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103522168 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 143 (T143A)
Ref Sequence ENSEMBL: ENSMUSP00000021328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021328] [ENSMUST00000107014]
AlphaFold Q9DA11
Predicted Effect probably benign
Transcript: ENSMUST00000021328
AA Change: T143A

PolyPhen 2 Score 0.123 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000021328
Gene: ENSMUSG00000020945
AA Change: T143A

DomainStartEndE-ValueType
LYZ1 20 146 3.58e-53 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107014
AA Change: T143A

PolyPhen 2 Score 0.123 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000102628
Gene: ENSMUSG00000020945
AA Change: T143A

DomainStartEndE-ValueType
LYZ1 20 146 3.58e-53 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,350,397 (GRCm39) N165S unknown Het
9530002B09Rik C A 4: 122,596,133 (GRCm39) N121K unknown Het
Abca1 A T 4: 53,109,284 (GRCm39) N141K probably benign Het
Amer1 ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC ATTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTC X: 94,470,889 (GRCm39) probably benign Het
Bco2 T C 9: 50,457,371 (GRCm39) N57S probably benign Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Cacna1a T A 8: 85,338,246 (GRCm39) W1709R probably damaging Het
Cep95 A G 11: 106,687,042 (GRCm39) E117G probably damaging Het
D17H6S53E T A 17: 35,346,145 (GRCm39) S19T possibly damaging Het
Dab2 G T 15: 6,451,762 (GRCm39) R126L probably damaging Het
Diaph3 T C 14: 86,893,916 (GRCm39) D31G probably damaging Het
Espl1 T A 15: 102,228,260 (GRCm39) L1678* probably null Het
Fam171b T C 2: 83,710,212 (GRCm39) V628A probably damaging Het
Fgf8 A T 19: 45,725,679 (GRCm39) V186E probably damaging Het
Fmnl2 A T 2: 53,006,941 (GRCm39) Y751F unknown Het
Frmpd1 A T 4: 45,278,886 (GRCm39) E537V Het
Garin3 A G 11: 46,297,673 (GRCm39) T326A Het
Grin1 C T 2: 25,187,909 (GRCm39) G529D probably damaging Het
Heatr1 C T 13: 12,429,306 (GRCm39) T872I possibly damaging Het
Hectd4 T C 5: 121,502,616 (GRCm39) I4240T probably benign Het
Hpd C T 5: 123,312,532 (GRCm39) R279H possibly damaging Het
Hyls1 T A 9: 35,473,398 (GRCm39) Q6L probably benign Het
Igfn1 A T 1: 135,897,229 (GRCm39) D1112E possibly damaging Het
Ighv1-82 T G 12: 115,916,158 (GRCm39) R117S probably damaging Het
Iqch G A 9: 63,389,935 (GRCm39) A748V Het
Kcnd2 G T 6: 21,727,180 (GRCm39) A578S probably benign Het
Klc2 A G 19: 5,161,565 (GRCm39) V315A possibly damaging Het
Klhl20 A T 1: 160,937,329 (GRCm39) D15E probably benign Het
Lamb2 G T 9: 108,365,830 (GRCm39) G1445W probably damaging Het
Lhx4 T A 1: 155,586,024 (GRCm39) I96F probably damaging Het
Nup93 G A 8: 95,041,249 (GRCm39) A796T probably damaging Het
Nutm2 T C 13: 50,628,475 (GRCm39) V513A probably benign Het
Or51s1 A G 7: 102,558,746 (GRCm39) V100A probably benign Het
Or52e4 A T 7: 104,706,275 (GRCm39) H274L probably damaging Het
Pcdh8 A G 14: 80,008,206 (GRCm39) V119A possibly damaging Het
Pkmyt1 T C 17: 23,954,691 (GRCm39) I427T probably benign Het
Polr1g A T 7: 19,091,817 (GRCm39) S97T possibly damaging Het
Polr3c T C 3: 96,629,866 (GRCm39) D222G probably null Het
Prickle2 A T 6: 92,683,096 (GRCm39) S11T probably benign Het
Prpf8 G A 11: 75,385,608 (GRCm39) A930T probably benign Het
Prss40 G T 1: 34,597,106 (GRCm39) H147Q probably damaging Het
Prune2 A T 19: 17,099,794 (GRCm39) D1766V probably benign Het
Qrich1 C T 9: 108,411,519 (GRCm39) T348M probably benign Het
Slc20a1 T C 2: 129,041,933 (GRCm39) Y99H probably damaging Het
Slc6a15 T C 10: 103,240,333 (GRCm39) V352A probably damaging Het
Ttll3 A G 6: 113,385,970 (GRCm39) Q601R possibly damaging Het
Virma T C 4: 11,507,078 (GRCm39) probably null Het
Washc4 A G 10: 83,417,258 (GRCm39) probably benign Het
Zdhhc18 A T 4: 133,342,541 (GRCm39) M191K possibly damaging Het
Zfp281 A G 1: 136,554,894 (GRCm39) N624S probably benign Het
Other mutations in Lyzl6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02319:Lyzl6 APN 11 103,525,862 (GRCm39) missense probably damaging 0.99
IGL02731:Lyzl6 APN 11 103,525,903 (GRCm39) nonsense probably null
R0023:Lyzl6 UTSW 11 103,527,697 (GRCm39) missense probably benign 0.42
R0078:Lyzl6 UTSW 11 103,524,795 (GRCm39) missense probably benign
R0367:Lyzl6 UTSW 11 103,527,578 (GRCm39) splice site probably null
R4811:Lyzl6 UTSW 11 103,525,851 (GRCm39) missense possibly damaging 0.93
R5257:Lyzl6 UTSW 11 103,525,899 (GRCm39) missense probably damaging 1.00
R5258:Lyzl6 UTSW 11 103,525,899 (GRCm39) missense probably damaging 1.00
R6211:Lyzl6 UTSW 11 103,525,889 (GRCm39) missense probably damaging 1.00
R7201:Lyzl6 UTSW 11 103,522,177 (GRCm39) missense probably benign 0.00
R7578:Lyzl6 UTSW 11 103,525,832 (GRCm39) missense probably benign 0.02
R7816:Lyzl6 UTSW 11 103,527,680 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCTTAAAGTGGTAGGTACACAGATG -3'
(R):5'- CAGACATGGGCTATGCTTCC -3'

Sequencing Primer
(F):5'- GGGAGCCGAGGTAAGATATTTCCC -3'
(R):5'- ACATGGGCTATGCTTCCTTCCC -3'
Posted On 2022-07-18