Incidental Mutation 'R9143:Zfp950'
ID 723592
Institutional Source Beutler Lab
Gene Symbol Zfp950
Ensembl Gene ENSMUSG00000074733
Gene Name zinc finger protein 950
Synonyms Gm34518, Zfp826, BC029127
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R9143 (G1)
Quality Score 61.0073
Status Validated
Chromosome 19
Chromosomal Location 61042692-61129297 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 61108778 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 102 (P102T)
Ref Sequence ENSEMBL: ENSMUSP00000146243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122927] [ENSMUST00000127117] [ENSMUST00000127290] [ENSMUST00000143264] [ENSMUST00000178819] [ENSMUST00000180544] [ENSMUST00000205712] [ENSMUST00000205854]
AlphaFold A0A0U1RQ46
Predicted Effect probably benign
Transcript: ENSMUST00000122927
Predicted Effect probably benign
Transcript: ENSMUST00000127117
Predicted Effect probably benign
Transcript: ENSMUST00000127290
Predicted Effect probably benign
Transcript: ENSMUST00000143264
Predicted Effect probably benign
Transcript: ENSMUST00000178819
Predicted Effect probably benign
Transcript: ENSMUST00000180544
AA Change: P102T

PolyPhen 2 Score 0.265 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably damaging
Transcript: ENSMUST00000205712
AA Change: P102T

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000205854
Meta Mutation Damage Score 0.5537 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (44/44)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele exhibit some postnatal lethality, altered craniofacial structures, kidney defects, embryonic hemorrhaging and cell migration defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9830107B12Rik T C 17: 48,452,605 (GRCm39) I111M probably damaging Het
Arid2 A G 15: 96,259,715 (GRCm39) I292V probably damaging Het
Atl3 T C 19: 7,509,408 (GRCm39) S379P probably benign Het
Btbd16 C T 7: 130,417,516 (GRCm39) R344C probably damaging Het
Ccnt1 G A 15: 98,441,688 (GRCm39) H527Y probably damaging Het
Ces1d T A 8: 93,912,707 (GRCm39) I244F probably damaging Het
Clec16a C A 16: 10,428,964 (GRCm39) S449R probably damaging Het
Cngb3 T A 4: 19,375,190 (GRCm39) probably benign Het
Col15a1 G C 4: 47,288,200 (GRCm39) probably benign Het
Cubn A T 2: 13,337,276 (GRCm39) probably benign Het
Dsp C A 13: 38,377,337 (GRCm39) S1707R probably benign Het
E330034G19Rik A T 14: 24,347,004 (GRCm39) Q162L possibly damaging Het
F830045P16Rik T C 2: 129,316,502 (GRCm39) N69S probably benign Het
Galnt10 C T 11: 57,612,146 (GRCm39) T62I probably benign Het
Gm19668 T C 10: 77,634,960 (GRCm39) D3G unknown Het
Hace1 T A 10: 45,562,764 (GRCm39) F760I probably damaging Het
Il20rb A G 9: 100,356,936 (GRCm39) Y65H probably damaging Het
Insl5 C A 4: 102,883,841 (GRCm39) V27L probably benign Het
Jade2 T C 11: 51,715,930 (GRCm39) D425G probably benign Het
Lipg T C 18: 75,087,272 (GRCm39) K183R probably benign Het
Lrrc59 T A 11: 94,525,456 (GRCm39) L84Q probably damaging Het
Lyst T A 13: 13,835,750 (GRCm39) F1811I probably damaging Het
Mcf2l A G 8: 13,062,883 (GRCm39) probably benign Het
Nfil3 A G 13: 53,121,792 (GRCm39) S371P probably benign Het
Nin A G 12: 70,137,349 (GRCm39) S76P Het
Nuak1 C T 10: 84,213,951 (GRCm39) probably null Het
Or8b47 A T 9: 38,427,917 (GRCm39) probably benign Het
Or8g19 A T 9: 39,055,722 (GRCm39) I109F possibly damaging Het
Pld1 A G 3: 28,132,643 (GRCm39) probably benign Het
Rcvrn T C 11: 67,590,890 (GRCm39) F158S possibly damaging Het
Skap2 T C 6: 51,885,409 (GRCm39) T200A probably benign Het
Slc6a1 G T 6: 114,292,503 (GRCm39) probably benign Het
Spag17 C T 3: 99,934,906 (GRCm39) T704M probably benign Het
Stxbp1 A G 2: 32,688,157 (GRCm39) S503P probably damaging Het
Susd5 A T 9: 113,924,879 (GRCm39) E254V possibly damaging Het
Sv2a T C 3: 96,097,983 (GRCm39) S529P possibly damaging Het
Tigd2 T A 6: 59,188,310 (GRCm39) N392K probably benign Het
Tmem131l A G 3: 83,842,220 (GRCm39) L525P probably benign Het
Tonsl T C 15: 76,514,824 (GRCm39) M1127V probably damaging Het
Top2a T A 11: 98,900,705 (GRCm39) E585V probably benign Het
Usp19 T G 9: 108,375,398 (GRCm39) L847R probably damaging Het
Vta1 T C 10: 14,551,776 (GRCm39) H141R possibly damaging Het
Zzz3 T C 3: 152,163,908 (GRCm39) I869T probably benign Het
Other mutations in Zfp950
AlleleSourceChrCoordTypePredicted EffectPPH Score
BB005:Zfp950 UTSW 19 61,107,938 (GRCm39) missense probably damaging 1.00
R1892:Zfp950 UTSW 19 61,107,549 (GRCm39) missense probably benign 0.05
R3442:Zfp950 UTSW 19 61,107,170 (GRCm39) nonsense probably null
R6062:Zfp950 UTSW 19 61,108,863 (GRCm39) missense possibly damaging 0.89
R7231:Zfp950 UTSW 19 61,107,650 (GRCm39) missense probably benign 0.28
R7285:Zfp950 UTSW 19 61,107,550 (GRCm39) missense probably benign 0.02
R7399:Zfp950 UTSW 19 61,107,593 (GRCm39) missense probably damaging 1.00
R7727:Zfp950 UTSW 19 61,108,379 (GRCm39) missense probably benign 0.33
R7744:Zfp950 UTSW 19 61,116,010 (GRCm39) splice site probably null
R7811:Zfp950 UTSW 19 61,108,353 (GRCm39) nonsense probably null
R7928:Zfp950 UTSW 19 61,107,938 (GRCm39) missense probably damaging 1.00
R8857:Zfp950 UTSW 19 61,116,001 (GRCm39) missense probably benign 0.14
R9711:Zfp950 UTSW 19 61,116,000 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ACATTCATAAGGTTTCTCTCCTGTA -3'
(R):5'- GGAGAACGCCATGATAAAACC -3'

Sequencing Primer
(F):5'- CTGTGATATGCAAAGGCTTTACCAC -3'
(R):5'- CGCCATGATAAAACCTTAAGATCTG -3'
Posted On 2022-08-31