Incidental Mutation 'R9699:Vmn1r159'
| ID |
729474 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r159
|
| Ensembl Gene |
ENSMUSG00000095931 |
| Gene Name |
vomeronasal 1 receptor 159 |
| Synonyms |
Gm16507 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Not available
|
| Stock # |
R9699 (G1)
|
| Quality Score |
193.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
22542113-22543030 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 22542675 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 119
(V119D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129692
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167871]
|
| AlphaFold |
K7N701 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167871
AA Change: V119D
PolyPhen 2
Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129692
Gene: ENSMUSG00000095931
AA Change: V119D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
297 |
1.8e-16 |
PFAM |
|
Pfam:7tm_1
|
31 |
288 |
7e-8 |
PFAM |
|
Pfam:V1R
|
41 |
296 |
6.3e-16 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700066M21Rik |
G |
T |
1: 57,416,927 (GRCm39) |
R33L |
probably benign |
Het |
| Abhd16b |
A |
T |
2: 181,136,518 (GRCm39) |
R473S |
probably benign |
Het |
| Adcyap1r1 |
A |
G |
6: 55,474,140 (GRCm39) |
D492G |
probably damaging |
Het |
| Ano5 |
A |
T |
7: 51,229,309 (GRCm39) |
N617I |
probably damaging |
Het |
| Cdh15 |
A |
G |
8: 123,588,769 (GRCm39) |
E281G |
probably benign |
Het |
| Clasp2 |
T |
A |
9: 113,738,614 (GRCm39) |
|
probably null |
Het |
| Dock8 |
G |
A |
19: 25,133,388 (GRCm39) |
|
probably null |
Het |
| Dscaml1 |
T |
C |
9: 45,654,315 (GRCm39) |
V1449A |
probably damaging |
Het |
| Ercc6 |
A |
G |
14: 32,282,703 (GRCm39) |
D732G |
probably damaging |
Het |
| Fam174c |
T |
A |
10: 80,010,161 (GRCm39) |
|
probably null |
Het |
| Fhip2b |
A |
T |
14: 70,825,179 (GRCm39) |
S386T |
possibly damaging |
Het |
| Gimap6 |
T |
C |
6: 48,684,951 (GRCm39) |
E45G |
probably benign |
Het |
| Glt1d1 |
C |
A |
5: 127,771,364 (GRCm39) |
T285K |
probably damaging |
Het |
| Gm14412 |
A |
T |
2: 177,007,636 (GRCm39) |
Y86* |
probably null |
Het |
| Grip2 |
A |
G |
6: 91,742,318 (GRCm39) |
S912P |
probably benign |
Het |
| Gucy2d |
T |
A |
7: 98,108,290 (GRCm39) |
I741N |
probably damaging |
Het |
| Hrh2 |
A |
T |
13: 54,368,299 (GRCm39) |
N92Y |
probably damaging |
Het |
| Klrc2 |
T |
A |
6: 129,637,452 (GRCm39) |
Q23L |
possibly damaging |
Het |
| Patl2 |
T |
C |
2: 121,955,591 (GRCm39) |
D285G |
probably damaging |
Het |
| Prpf40a |
A |
G |
2: 53,035,735 (GRCm39) |
V685A |
probably benign |
Het |
| Rspry1 |
A |
G |
8: 95,380,857 (GRCm39) |
H511R |
probably benign |
Het |
| Scarb1 |
G |
T |
5: 125,374,296 (GRCm39) |
A279E |
probably damaging |
Het |
| Sell |
A |
G |
1: 163,893,114 (GRCm39) |
E110G |
probably damaging |
Het |
| Sftpc |
A |
T |
14: 70,760,143 (GRCm39) |
I38N |
probably damaging |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Slc5a4b |
C |
A |
10: 75,946,674 (GRCm39) |
V33F |
probably damaging |
Het |
| Smad7 |
A |
G |
18: 75,527,161 (GRCm39) |
S336G |
probably damaging |
Het |
| Tnpo3 |
C |
T |
6: 29,565,768 (GRCm39) |
V529I |
probably benign |
Het |
| Trafd1 |
A |
G |
5: 121,517,727 (GRCm39) |
V22A |
probably benign |
Het |
| Tssk1 |
A |
G |
16: 17,712,545 (GRCm39) |
E110G |
probably damaging |
Het |
| Vmn1r191 |
A |
G |
13: 22,363,355 (GRCm39) |
F133S |
probably benign |
Het |
| Vwa1 |
G |
A |
4: 155,857,336 (GRCm39) |
P154L |
probably damaging |
Het |
| Zfp830 |
C |
T |
11: 82,655,805 (GRCm39) |
T203I |
possibly damaging |
Het |
| Zw10 |
G |
T |
9: 48,966,942 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn1r159 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
ANU23:Vmn1r159
|
UTSW |
7 |
22,542,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1183:Vmn1r159
|
UTSW |
7 |
22,543,019 (GRCm39) |
missense |
probably null |
0.80 |
|
R1522:Vmn1r159
|
UTSW |
7 |
22,542,693 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1700:Vmn1r159
|
UTSW |
7 |
22,542,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2570:Vmn1r159
|
UTSW |
7 |
22,542,307 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3620:Vmn1r159
|
UTSW |
7 |
22,542,258 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4939:Vmn1r159
|
UTSW |
7 |
22,542,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4985:Vmn1r159
|
UTSW |
7 |
22,542,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6161:Vmn1r159
|
UTSW |
7 |
22,542,612 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6365:Vmn1r159
|
UTSW |
7 |
22,542,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn1r159
|
UTSW |
7 |
22,542,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7633:Vmn1r159
|
UTSW |
7 |
22,542,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7817:Vmn1r159
|
UTSW |
7 |
22,542,487 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7846:Vmn1r159
|
UTSW |
7 |
22,542,696 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8008:Vmn1r159
|
UTSW |
7 |
22,542,665 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8019:Vmn1r159
|
UTSW |
7 |
22,542,248 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8222:Vmn1r159
|
UTSW |
7 |
22,542,608 (GRCm39) |
nonsense |
probably null |
|
|
R8291:Vmn1r159
|
UTSW |
7 |
22,542,255 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8817:Vmn1r159
|
UTSW |
7 |
22,542,559 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9170:Vmn1r159
|
UTSW |
7 |
22,542,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9242:Vmn1r159
|
UTSW |
7 |
22,542,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9467:Vmn1r159
|
UTSW |
7 |
22,542,141 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9525:Vmn1r159
|
UTSW |
7 |
22,542,417 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9601:Vmn1r159
|
UTSW |
7 |
22,542,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTACAATGAATCCAGAAGTGG -3'
(R):5'- CCAGACAGGTGATTTTAAGCCAC -3'
Sequencing Primer
(F):5'- GTGGAACAGAACAAGTTGCTTTTAG -3'
(R):5'- ACATGTCTGTGGCCAATGC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation