Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01304:Zfp870'

73355

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp870

Ensembl Gene

ENSMUSG00000095325

Gene Name

zinc finger protein 870

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL01304

Quality Score

Status

Chromosome

Chromosomal Location

33098193-33110616 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33101980 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 450 (C450S)

Ref Sequence

ENSEMBL: ENSMUSP00000136197 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178401] [ENSMUST00000228075]

AlphaFold

Q6NZJ3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000178401
AA Change: C450S

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000136197
Gene: ENSMUSG00000095325
AA Change: C450S

Domain	Start	End	E-Value	Type
KRAB	3	60	1.01e-19	SMART
ZnF_C2H2	193	215	4.5e1	SMART
ZnF_C2H2	221	241	6.4e0	SMART
ZnF_C2H2	277	299	2.24e-3	SMART
ZnF_C2H2	305	327	9.58e-3	SMART
ZnF_C2H2	333	355	2.86e-1	SMART
ZnF_C2H2	361	383	6.42e-4	SMART
ZnF_C2H2	389	411	1.18e-2	SMART
ZnF_C2H2	417	439	3.89e-3	SMART
ZnF_C2H2	445	467	5.5e-3	SMART
ZnF_C2H2	473	495	4.47e-3	SMART
ZnF_C2H2	501	523	5.9e-3	SMART
ZnF_C2H2	529	551	3.11e-2	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228075
AA Change: C451S

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228410

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	A	T	19: 57,204,153 (GRCm39)	D79E	probably benign	Het
Aplf	A	C	6: 87,618,882 (GRCm39)	S421A	possibly damaging	Het
Arnt	T	G	3: 95,355,696 (GRCm39)	D13E	probably damaging	Het
Asap1	T	C	15: 64,184,298 (GRCm39)	E45G	probably damaging	Het
C2cd2l	T	C	9: 44,230,884 (GRCm39)	N101S	probably damaging	Het
Cby2	T	A	14: 75,830,085 (GRCm39)	D36V	possibly damaging	Het
Chmp7	G	A	14: 69,956,062 (GRCm39)	P402L	probably benign	Het
Cir1	A	T	2: 73,118,068 (GRCm39)		probably null	Het
Clock	A	G	5: 76,414,202 (GRCm39)		probably null	Het
Col18a1	T	G	10: 76,911,975 (GRCm39)		probably benign	Het
Csf2ra	G	A	19: 61,215,271 (GRCm39)	H115Y	possibly damaging	Het
Cspg5	T	A	9: 110,085,236 (GRCm39)	L469H	probably damaging	Het
Dapk2	T	C	9: 66,139,139 (GRCm39)		probably benign	Het
F13a1	T	C	13: 37,172,852 (GRCm39)	D176G	probably benign	Het
Fbn2	T	C	18: 58,194,817 (GRCm39)	E1448G	probably damaging	Het
Gtf2b	C	T	3: 142,487,359 (GRCm39)	S265L	probably benign	Het
Hmcn1	C	T	1: 150,498,675 (GRCm39)	G4068D	probably damaging	Het
Krt81	G	A	15: 101,361,269 (GRCm39)	H104Y	probably benign	Het
Ksr1	T	C	11: 78,918,468 (GRCm39)	Q562R	probably damaging	Het
Lrif1	C	T	3: 106,639,049 (GRCm39)	P20S	probably damaging	Het
Mamdc4	T	C	2: 25,453,588 (GRCm39)	T1194A	possibly damaging	Het
Med18	C	A	4: 132,186,930 (GRCm39)	A190S	probably damaging	Het
Mia2	G	A	12: 59,151,324 (GRCm39)	E105K	probably damaging	Het
Mnt	T	A	11: 74,733,011 (GRCm39)	Y48N	probably damaging	Het
Mpp4	A	C	1: 59,188,678 (GRCm39)		probably null	Het
Or4b1b	G	A	2: 90,112,425 (GRCm39)	P165S	possibly damaging	Het
Popdc3	T	G	10: 45,194,005 (GRCm39)	S269A	probably benign	Het
Ppp6r3	A	T	19: 3,517,261 (GRCm39)	M662K	probably damaging	Het
Qser1	C	A	2: 104,617,976 (GRCm39)	Q945H	probably damaging	Het
Rad52	A	G	6: 119,895,594 (GRCm39)	E198G	probably damaging	Het
Ranbp17	A	G	11: 33,216,147 (GRCm39)	V867A	possibly damaging	Het
Rdh16	G	T	10: 127,649,365 (GRCm39)	A274S	probably benign	Het
Slco1a5	G	T	6: 142,187,876 (GRCm39)	Q488K	probably benign	Het
Snai2	T	C	16: 14,524,635 (GRCm39)	I47T	probably benign	Het
Snw1	T	C	12: 87,500,685 (GRCm39)	D358G	possibly damaging	Het
Speg	T	C	1: 75,404,841 (GRCm39)	F2878L	probably benign	Het
Spg11	T	C	2: 121,902,771 (GRCm39)	Y1386C	probably damaging	Het
Tgfb2	A	C	1: 186,357,670 (GRCm39)	I435S	probably damaging	Het
Ttc9b	G	A	7: 27,355,410 (GRCm39)	D227N	probably benign	Het
Txndc2	T	C	17: 65,945,448 (GRCm39)	E243G	possibly damaging	Het
Usp28	A	G	9: 48,938,119 (GRCm39)	D563G	probably damaging	Het
Vmn1r77	T	C	7: 11,775,962 (GRCm39)	V178A	probably damaging	Het
Zfp316	A	G	5: 143,240,181 (GRCm39)	F613L	probably benign	Het

Other mutations in Zfp870

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1591:Zfp870	UTSW	17	33,102,990 (GRCm39)	missense	probably damaging	1.00
R1892:Zfp870	UTSW	17	33,102,863 (GRCm39)	missense	possibly damaging	0.66
R1941:Zfp870	UTSW	17	33,101,778 (GRCm39)	missense	possibly damaging	0.71
R1997:Zfp870	UTSW	17	33,103,027 (GRCm39)	missense	possibly damaging	0.66
R2289:Zfp870	UTSW	17	33,102,334 (GRCm39)	missense	probably benign	0.27
R4240:Zfp870	UTSW	17	33,104,710 (GRCm39)	missense	probably benign	0.00
R4860:Zfp870	UTSW	17	33,102,314 (GRCm39)	nonsense	probably null
R4860:Zfp870	UTSW	17	33,102,314 (GRCm39)	nonsense	probably null
R5306:Zfp870	UTSW	17	33,102,627 (GRCm39)	missense	probably damaging	1.00
R6425:Zfp870	UTSW	17	33,102,045 (GRCm39)	missense	possibly damaging	0.66
R6736:Zfp870	UTSW	17	33,102,570 (GRCm39)	missense	probably benign
R7054:Zfp870	UTSW	17	33,102,456 (GRCm39)	missense	probably damaging	0.97
R7291:Zfp870	UTSW	17	33,102,828 (GRCm39)	missense	probably damaging	0.97
R7466:Zfp870	UTSW	17	33,102,736 (GRCm39)	missense	possibly damaging	0.66
R7681:Zfp870	UTSW	17	33,101,664 (GRCm39)	missense	probably benign
R8230:Zfp870	UTSW	17	33,102,663 (GRCm39)	missense	possibly damaging	0.46
R8346:Zfp870	UTSW	17	33,102,843 (GRCm39)	missense	possibly damaging	0.92
R8673:Zfp870	UTSW	17	33,101,904 (GRCm39)	missense	probably damaging	0.97
R8695:Zfp870	UTSW	17	33,102,679 (GRCm39)	missense	possibly damaging	0.46
R8736:Zfp870	UTSW	17	33,104,966 (GRCm39)	missense	possibly damaging	0.92
R9057:Zfp870	UTSW	17	33,102,793 (GRCm39)	missense	probably benign	0.27

Posted On

2013-10-07