Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01510:Cd200r2'

89173

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cd200r2

Ensembl Gene

ENSMUSG00000090176

Gene Name

Cd200 receptor 2

Synonyms

CD200 cell surface glycoprotein receptor isoform 2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01510

Quality Score

Status

Chromosome

Chromosomal Location

44687460-44736203 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 44729674 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 110 (I110L)

Ref Sequence

ENSEMBL: ENSMUSP00000099869 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102805]

AlphaFold

Q6XJV6

Predicted Effect

probably benign
Transcript: ENSMUST00000102805
AA Change: I110L

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000099869
Gene: ENSMUSG00000090176
AA Change: I110L

Domain	Start	End	E-Value	Type
IG	23	126	1.06e-2	SMART
IG_like	128	249	1.85e2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	T	C	4: 53,143,979 (GRCm39)	Q6R	probably damaging	Het
Adam5	A	T	8: 25,294,481 (GRCm39)	C373S	probably damaging	Het
Adgre4	T	C	17: 56,125,760 (GRCm39)		probably null	Het
Akap10	A	T	11: 61,768,846 (GRCm39)	M614K	possibly damaging	Het
Amigo2	T	C	15: 97,142,962 (GRCm39)	T487A	probably benign	Het
Asap1	T	C	15: 64,030,777 (GRCm39)	D300G	probably damaging	Het
Atp4a	C	A	7: 30,420,216 (GRCm39)	L788M	probably benign	Het
Bcl3	T	A	7: 19,543,539 (GRCm39)	H309L	probably damaging	Het
Cblc	T	C	7: 19,519,200 (GRCm39)	N376S	probably benign	Het
Ceacam3	T	C	7: 16,893,767 (GRCm39)	M426T	probably benign	Het
Cep295	G	A	9: 15,265,922 (GRCm39)	R29*	probably null	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Ctps1	G	T	4: 120,416,041 (GRCm39)	T194K	probably damaging	Het
Cul3	A	G	1: 80,260,396 (GRCm39)	S318P	probably damaging	Het
Fasl	A	T	1: 161,609,522 (GRCm39)	S155T	possibly damaging	Het
Gldc	C	T	19: 30,091,121 (GRCm39)		probably null	Het
Gpr21	T	A	2: 37,408,433 (GRCm39)	C326*	probably null	Het
Gtf2a1	A	G	12: 91,534,607 (GRCm39)	S216P	probably benign	Het
Hoxb5	A	T	11: 96,194,818 (GRCm39)	S127C	possibly damaging	Het
Htt	A	T	5: 35,064,856 (GRCm39)	Q3023L	probably damaging	Het
Kalrn	T	A	16: 34,055,700 (GRCm39)	H855L	possibly damaging	Het
Lars1	T	C	18: 42,375,174 (GRCm39)	I289V	probably benign	Het
Lrig3	C	A	10: 125,844,567 (GRCm39)	T677K	probably damaging	Het
Mapk7	A	T	11: 61,381,986 (GRCm39)	W309R	probably damaging	Het
Mmp12	A	G	9: 7,358,307 (GRCm39)	T468A	possibly damaging	Het
Muc5b	A	T	7: 141,412,798 (GRCm39)	N1915Y	unknown	Het
Naprt	A	G	15: 75,762,837 (GRCm39)		probably benign	Het
Nfatc1	T	C	18: 80,741,403 (GRCm39)	Y199C	probably damaging	Het
Or7e166	A	T	9: 19,624,575 (GRCm39)	I151F	probably benign	Het
Or8g51	T	C	9: 38,609,201 (GRCm39)	I158V	probably benign	Het
Phip	T	A	9: 82,795,924 (GRCm39)	I566F	probably benign	Het
Pnpla3	T	A	15: 84,055,273 (GRCm39)		probably benign	Het
Ptpn13	C	T	5: 103,710,166 (GRCm39)	T1567I	probably damaging	Het
Ptpn20	A	G	14: 33,360,343 (GRCm39)		probably null	Het
Ptprq	G	T	10: 107,547,909 (GRCm39)	T163K	probably damaging	Het
Slc8a1	A	G	17: 81,955,794 (GRCm39)	C415R	probably damaging	Het
Slco4c1	A	G	1: 96,795,678 (GRCm39)	S127P	probably damaging	Het
Tcerg1l	A	T	7: 137,996,034 (GRCm39)		probably benign	Het
Thbd	C	T	2: 148,248,894 (GRCm39)	V325M	probably damaging	Het
Trim37	G	A	11: 87,068,686 (GRCm39)	R344H	probably damaging	Het
Ttn	T	C	2: 76,703,109 (GRCm39)		probably benign	Het
Uvrag	G	A	7: 98,653,796 (GRCm39)	Q65*	probably null	Het
Wrap53	G	A	11: 69,453,566 (GRCm39)	S342L	possibly damaging	Het
Zbtb11	T	G	16: 55,810,706 (GRCm39)	V288G	probably damaging	Het

Other mutations in Cd200r2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cd200r2	APN	16	44,729,651 (GRCm39)	missense	probably damaging	1.00
IGL01019:Cd200r2	APN	16	44,729,832 (GRCm39)	splice site	probably benign
IGL01480:Cd200r2	APN	16	44,729,629 (GRCm39)	missense	probably null	1.00
IGL02202:Cd200r2	APN	16	44,729,723 (GRCm39)	missense	probably damaging	1.00
IGL02492:Cd200r2	APN	16	44,729,903 (GRCm39)	missense	probably damaging	1.00
IGL02499:Cd200r2	APN	16	44,734,948 (GRCm39)	missense	possibly damaging	0.47
R0066:Cd200r2	UTSW	16	44,730,037 (GRCm39)	missense	possibly damaging	0.94
R0066:Cd200r2	UTSW	16	44,730,037 (GRCm39)	missense	possibly damaging	0.94
R0503:Cd200r2	UTSW	16	44,698,325 (GRCm39)	start codon destroyed	probably null	0.93
R0526:Cd200r2	UTSW	16	44,735,410 (GRCm39)	missense	probably damaging	1.00
R1118:Cd200r2	UTSW	16	44,729,969 (GRCm39)	missense	probably damaging	1.00
R1119:Cd200r2	UTSW	16	44,729,969 (GRCm39)	missense	probably damaging	1.00
R2393:Cd200r2	UTSW	16	44,729,630 (GRCm39)	missense	probably damaging	1.00
R5450:Cd200r2	UTSW	16	44,729,934 (GRCm39)	missense	probably benign	0.04
R7466:Cd200r2	UTSW	16	44,729,537 (GRCm39)	missense	probably damaging	0.97
R9762:Cd200r2	UTSW	16	44,729,420 (GRCm39)	missense	probably benign	0.00

Posted On

2013-12-03