Incidental Mutation 'IGL01531:Olfr629'
ID89750
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr629
Ensembl Gene ENSMUSG00000047545
Gene Nameolfactory receptor 629
SynonymsMOR26-2, GA_x6K02T2PBJ9-6466772-6465828
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #IGL01531
Quality Score
Status
Chromosome7
Chromosomal Location103739775-103744943 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 103741114 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 42 (N42I)
Ref Sequence ENSEMBL: ENSMUSP00000149272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051346] [ENSMUST00000213906] [ENSMUST00000216300]
Predicted Effect probably damaging
Transcript: ENSMUST00000051346
AA Change: N42I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052662
Gene: ENSMUSG00000047545
AA Change: N42I

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 4.9e-103 PFAM
Pfam:7TM_GPCR_Srsx 35 307 1.6e-6 PFAM
Pfam:7tm_1 41 292 5.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213906
AA Change: N42I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216300
AA Change: N42I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T A 13: 119,466,958 probably null Het
Adcy1 T C 11: 7,169,414 V1019A possibly damaging Het
Blm A G 7: 80,474,071 Y1004H probably damaging Het
Btbd11 T C 10: 85,629,205 probably benign Het
Cachd1 A C 4: 100,953,034 I278L probably benign Het
Ddx18 T A 1: 121,564,586 T131S probably benign Het
Dgkd T C 1: 87,880,411 F67S probably damaging Het
Dlgap1 A G 17: 70,516,379 T120A probably damaging Het
Dnaja3 T G 16: 4,694,404 V224G probably damaging Het
Dntt A T 19: 41,053,238 R454* probably null Het
Dync2h1 T A 9: 7,071,111 T3083S probably benign Het
Eea1 C A 10: 96,031,677 T1045K probably damaging Het
Gpnmb T A 6: 49,047,458 probably benign Het
Hirip3 A G 7: 126,863,376 E108G possibly damaging Het
Il33 C A 19: 29,951,981 Q35K possibly damaging Het
Il6ra G A 3: 89,886,043 L267F probably damaging Het
Impact C T 18: 12,976,019 S69F probably benign Het
Klk9 G A 7: 43,792,251 G39D probably damaging Het
Ldah A G 12: 8,227,337 D91G probably benign Het
Lrp4 T C 2: 91,511,553 L1837P probably damaging Het
Mov10l1 T A 15: 89,054,352 H1204Q probably damaging Het
Nlrp4c A G 7: 6,060,656 E21G probably damaging Het
Olfr361 T C 2: 37,085,395 M118V possibly damaging Het
Osbpl1a T G 18: 12,933,581 K40N probably damaging Het
Ptprd T C 4: 76,085,520 T1010A probably damaging Het
Rp1 A G 1: 4,348,945 V648A probably benign Het
Scn9a T C 2: 66,537,378 K654E probably benign Het
Sema3d A G 5: 12,541,080 I309V probably benign Het
Slc6a2 T C 8: 92,995,682 L519P probably damaging Het
Stard9 A G 2: 120,673,604 I211V possibly damaging Het
Stau2 T C 1: 16,345,698 *480W probably null Het
Svopl T C 6: 38,026,941 probably benign Het
Virma A G 4: 11,528,753 E1330G probably damaging Het
Zan G A 5: 137,424,612 T2713I unknown Het
Other mutations in Olfr629
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Olfr629 APN 7 103740965 missense probably benign 0.03
IGL02263:Olfr629 APN 7 103741055 missense probably damaging 1.00
IGL02543:Olfr629 APN 7 103740503 missense possibly damaging 0.50
BB005:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
BB015:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
R0744:Olfr629 UTSW 7 103740925 missense probably damaging 1.00
R0836:Olfr629 UTSW 7 103740925 missense probably damaging 1.00
R1509:Olfr629 UTSW 7 103741036 missense probably benign 0.12
R1671:Olfr629 UTSW 7 103740410 missense possibly damaging 0.73
R1781:Olfr629 UTSW 7 103740821 missense probably benign 0.00
R1848:Olfr629 UTSW 7 103741174 missense probably benign 0.08
R3930:Olfr629 UTSW 7 103740587 missense probably damaging 1.00
R4125:Olfr629 UTSW 7 103741000 missense probably benign 0.22
R5321:Olfr629 UTSW 7 103740655 missense probably damaging 0.97
R6141:Olfr629 UTSW 7 103740787 missense probably damaging 1.00
R6232:Olfr629 UTSW 7 103740454 missense probably damaging 1.00
R6489:Olfr629 UTSW 7 103740668 missense probably benign 0.09
R6755:Olfr629 UTSW 7 103740500 missense probably damaging 0.99
R7526:Olfr629 UTSW 7 103740400 missense probably damaging 1.00
R7928:Olfr629 UTSW 7 103741190 missense probably damaging 1.00
R8839:Olfr629 UTSW 7 103740814 missense probably benign 0.00
Z1177:Olfr629 UTSW 7 103741068 missense probably damaging 1.00
Posted On2013-12-03